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A creation of comprehensive and organized control system for a prevention of allergy due to agricultural works

建立全面、有组织的预防农业过敏的控制体系

基本信息

批准号：
12470087
负责人：
UEDA Atsushi
金额：
$ 7.87万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

To create a comprehensive-organized-consecutive control model for a prevention of allergy due to agricultural works we conducted three researchs, as ; (1) To develop a epidemiological research model for analyzing actual status and causing factors of agricultural work-related allergy, (2) To develop a experimental model to predict earlier allergenicity and to settle a TLV of each substance generated from agricultural work places, (3) To establish a comprehensive-organized-consecutive control model for allergic hazards of agricultural works. As the results ; (1) We developed the field survey models for analyzing work loads and conditions of agricultural works and sampling and refining allergens in the work sites and developed questionnaire form to collect allergic cases in agricultural workers, (2) We developed and improved experimental model, such as, inhalative exposure method for immediate-type allergy and guinea-pig maximization test for delayed-type allergy to detect and determine allergenicity of substances in agricultural work sites, (3) We, finally, create the control model for preventing allergy due to agricultural works with 6 consecutive steps, consisting with to detect and predict allergic substances and allergic cases and to determine of it's allergenicity by experimental methods and to develop control measures for technical improvement of agricultural work conditions and medical controls for the agricultural workers.

为了建立一个全面的有组织的连续控制模式，以预防由于农业工程引起的过敏，我们进行了三项研究，作为;（1）开发用于分析农业工作相关过敏的实际状况和致敏因素的流行病学研究模型，（2）开发用于预测早期过敏原性并确定农业工作场所产生的每种物质的TLV的实验模型，（3）建立农业工程过敏性危害的综合-组织-连续控制模式。作为结果;（1）建立了农业劳动者工作负荷和工作条件分析的现场调查模型，并对现场过敏原进行了采样和提炼，同时建立了农业劳动者过敏病例调查问卷。（2）建立并改进了实验模型，如：吸入暴露法测定速发型变态反应和豚鼠最大剂量试验测定迟发型变态反应类型过敏，以检测和确定农业作业场所物质的过敏原性;（3）最后，我们建立了预防农业作业过敏的控制模型，包括6个连续步骤，包括检测和预测过敏物质和过敏病例，通过实验方法确定其致敏性，并制定控制措施，农业工作条件和农业工人的医疗控制。