Study on Threshold Limit Values of Occupational Allergens

职业过敏原阈值限值研究

• 批准号: 61570261
• 负责人: UEDA Atsushi
• 金额: $ 1.22万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570261/
• 关键词: Occupational allergen; Threshold Limit Values; Allergy; TDI; Chicken; Statice; Inhalation sensitizing experiment; ボデイプレチスモグラム; 感作性物質

First, we proved that there were only 8 countries which had the list or remark on occupational allergens and even in those countries no threshold limit values was set for preventing allergic diseases by an exposure to those allergens through personal communications and referring some reports. And we made a proposal of a new list of 80 substances for occupational allergens.Next, we deviced an experimental system for a prediction and determination of it's dose-response relationship of occupational allergic substances, consisted of an equipment of generation and regulation of a test sample, exposure chamber, body-plethysmogramm, p-transducer, amplifier and recorder for respiratory rates, improving Karol's model, and proved it's appropriateness for that purpose by conducting an animal (guinea pigs) experiment of above mentioned using TDI as the test substance. It was also indicated that the grade of allergic reaction was depending on inhalative concentrations for sensitizing exposures and, nevertheless no respiratory immune reaction was observed by an exposure of 0.02 ppm TDI, skin immune reaction was observed at that concentration.Third, we made it clear that a feather of chicken and flower of statice might cause human immediate allergic condition through conducting a field survey on allergy among workers handling those substances.

首先，我们证明了只有8个国家有关于职业过敏原的清单或备注，即使在这些国家，也没有通过个人通信和参考一些报告来设定通过暴露于这些过敏原预防过敏性疾病的阈值限值。其次，我们改进Karol模型，设计了一套职业性过敏原剂量-反应关系预测测定系统，该系统由样品产生和调节装置、暴露室、体容积描记仪、P传感器、放大器和呼吸频率记录仪组成，并通过使用TDI作为供试品进行上述动物（豚鼠）实验证明其适用于该目的。还表明过敏反应的等级取决于致敏暴露的吸入浓度，然而，0.02ppm TDI暴露未观察到呼吸道免疫反应，在该浓度下观察到皮肤免疫反应。我们通过对100多名中国人进行过敏现场调查，明确了鸡毛和花的过敏可能会引起人的立即过敏。处理这些物质的工人。

项目成果

Toshio Matsushita: "Listing for Occupational Allergens" Japanese Journal of Industrial Health. 29. 767-767 (1987)

Toshio Matsushita：“职业过敏原列表”日本工业健康杂志。

Atsushi Ueda: "Allergic Conditions of Workers Engaged in the Process of Braking-up Chickens" Proceedings of the 61th Annual Meeting of Japan Association of Industrial Health. (1988)

Atsushi Ueda：“从事鸡熟化过程的工人的过敏状况”日本工业健康协会第 61 届年会记录。