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The long term health effects of the exposure to sarin and by-products

接触沙林及其副产品对健康的长期影响

基本信息

批准号：
12470089
负责人：
MINAMI Masayasu
金额：
$ 8.19万
依托单位：
Nippon Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470089/
关键词：
sarin by-products sarin metabolites fluorine methylphasphonate human terrorism Sarin Biological monitor Fluorine neuro foxicity Tokyo Sarin disaster サリンジエチル・アニリン S9-mix DIMP

项目摘要

The long term health effects of the exposure to sarin and by-products.1. Biological monitoring ; We assayesd the metabolites of exposed substances and the results suggested that the patients were exposed to not only sarin but also fluoride and isopropanol containing by-products daring sarin synthesis. One of the metabolites, MPA excreted was far exceeding the human lethal dose of sarin and the amount of MPA excretion per person was inversely correlated with the garvity of the symptom. Even though the high level of MPA excretion, the lethality was low 1 death / 4 person received medical treatment in our ICU (Hui and Minami, Clin. Chim. Acta 2000 ; 302 : 171 - 188).2. The effects on central and autonomic nervous systems ; A cross-sectional epidemiological study was conducted 3 years after the disaster. 56 male exposed and 52 referent spersons matched for age and occupation were tested concerning various kinds of central and autonomic nervous functions. The exposed group performed less well in backward digit span tests of memory function and Benton visual retention test. The test results has no relationship with PTSD symptoms. These results suggested the chronic decline in memory function (Environ, Hlth Perspect. 2001 ; 1169 - 1173).3. Other studies now in progress ; i) One of the marker s of abberated DNA function, 8-hydroxy deoxiguanosine excretion in the urine of patients is now under study. ii) We find an isozyme which metabolise organic phosphate, paraoxonase. The enzyme which we found has optimal pH 6.5.

长期接触沙林及其副产品对健康的影响。生物监测;我们分析了暴露物质的代谢产物，结果表明，患者不仅暴露于沙林，而且还暴露于沙林合成过程中含有氟和异丙醇的副产物。代谢产物之一MPA的排泄量远远超过了沙林的人体致死量，且MPA的人均排泄量与症状的严重程度呈负相关。即使MPA排泄水平高，致死率也低，1例死亡/ 4例患者在我们的ICU接受药物治疗（Hui和Minami，Clin. Chim. Acta 2000 ; 302：171 - 188）。对中枢和自主神经系统的影响;在灾难发生后3年进行了横断面流行病学研究。本文对56名男性接触者和52名年龄、职业相匹配的对照者进行了各种中枢和自主神经功能的测定。在记忆功能的向后数字广度测试和Benton视觉保持测试中，接触组的表现较差。测试结果与PTSD症状无关。这些结果表明记忆功能的慢性下降（Environ，Hlth Perspect. 2001 ; 1169 - 1173）。其他研究正在进行中; i）异常DNA功能的标志物之一，患者尿液中的8-羟基脱氧鸟苷排泄现在正在研究中。ii）发现了一种代谢有机磷的同工酶--对氧磷酶。该酶的最适pH为6.5。