The long term health effects of the exposure to sarin and by-products

接触沙林及其副产品对健康的长期影响。生物监测；我们检测了暴露物质的代谢物，结果表明患者不仅暴露于沙林，还暴露于沙林合成时的氟化物和含异丙醇的副产物。其中一种代谢物，MPA的排泄量远远超过沙林对人的致死剂量，人均MPA的排泄量与症状的严重程度呈负相关。尽管MPA排泄水平较高，但致死率较低，1例死亡/ 4例在我院ICU（惠南门诊）接受治疗。詹。学报；2000；[au:] [au:]对中枢和自主神经系统的影响；灾后3年进行了横断面流行病学研究。对56名男性暴露者和52名年龄、职业匹配的参照者进行了各种中枢神经和自主神经功能的测试。暴露组在记忆功能倒向数字广度测验和Benton视觉保持测验中表现较差。测试结果与PTSD症状无关。这些结果表明记忆功能的慢性衰退（环境，健康展望，2001;1169 - 1173）。其他正在进行的研究；i)作为DNA功能减退的标志之一，8-羟基脱氧鸟苷在患者尿液中的排泄情况正在研究中。ii)我们发现了一种代谢有机磷的同工酶，对氧磷酶。我们发现的酶的最佳pH值为6.5。

The long term health effects of the exposure to sarin and by-products.1. Biological monitoring ; We assayesd the metabolites of exposed substances and the results suggested that the patients were exposed to not only sarin but also fluoride and isopropanol containing by-products daring sarin synthesis. One of the metabolites, MPA excreted was far exceeding the human lethal dose of sarin and the amount of MPA excretion per person was inversely correlated with the garvity of the symptom. Even though the high level of MPA excretion, the lethality was low 1 death / 4 person received medical treatment in our ICU (Hui and Minami, Clin. Chim. Acta 2000 ; 302 : 171 - 188).2. The effects on central and autonomic nervous systems ; A cross-sectional epidemiological study was conducted 3 years after the disaster. 56 male exposed and 52 referent spersons matched for age and occupation were tested concerning various kinds of central and autonomic nervous functions. The exposed group performed less well in backward digit span tests of memory function and Benton visual retention test. The test results has no relationship with PTSD symptoms. These results suggested the chronic decline in memory function (Environ, Hlth Perspect. 2001 ; 1169 - 1173).3. Other studies now in progress ; i) One of the marker s of abberated DNA function, 8-hydroxy deoxiguanosine excretion in the urine of patients is now under study. ii) We find an isozyme which metabolise organic phosphate, paraoxonase. The enzyme which we found has optimal pH 6.5.