Research on the Neural Network Involved in Changing Attntion in Schizophrenia
精神分裂症注意力改变的神经网络研究
基本信息
- 批准号:12470195
- 负责人:
- 金额:$ 6.53万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To investigate the neural substrate of psychotic symptoms in schizophrenia, MEG and PET activation studies were conducted to schizophrenic patients and healthy subjects by using attention control tasks and emotional stimulation tasks which require mobilization of extensive neural activities.1.MEG activation studies by the Stroop task and word production taskOn the Stroop color word interference task, event-related desynchronization (ERD) was observed in bilateral dorsolateral prefrontal cortex (DLPFC) in normal subjects and schizophrenics of undifferentiated type although that was not observed in the left DLPFC in schizophrenics of paranoid type. On word production task, ERD was observed in bilateral posterior inferior frontal gyrus and posterior superior temporal gyrus in normals though not in patients with auditory hallucinations. These findings may support the hypothesis that positive symptoms such as hallucinations and delusions are produced by disinhibited activities of lower cortical systems out of the control by the prefrontal cortex.2.PET activating studies by emotion processing tasksOn emotionally valenced episodic memory task, the posterior portion of the cingulate gyrus was selectively activated in normal subjects. By repetitive provoking of emotion, activated cerebral region transferred from the posterior cingulate gyrus to the bilateral occipital association cortex with emotion being habituated. On fear conditioned semantic memory task, the left superior temporal gyrus and the right amygdale were simultaneously activated. Although patients could not be examined in these studies, the findings would give some suggestions to future studies on the mechanism of schizophrenic symptoms, since some types of delusion may be explained as a disproportional dominance of emotional judgment to cognitive interpretation of subjects.
为探讨精神分裂症精神病症状的神经基础,采用注意控制任务和情绪刺激任务对精神分裂症患者和健康被试进行了MEG和PET激活研究,这些任务需要调动广泛的神经活动。在Stroop彩色词干扰任务中,正常受试者和未分化型精神分裂症患者的双侧背外侧前额叶皮层(DLPFC)出现事件相关失同步(ERD),而偏执型精神分裂症患者的左侧DLPFC未出现事件相关失同步。在单词生成任务中,正常患者双侧额后下回和颞后上回出现ERD,幻听患者无ERD。这些发现可能支持这样一种假设,即幻觉和妄想等阳性症状是由前额叶皮层控制的下皮层系统的去抑制活动产生的。在情绪性情景记忆任务中,正常被试的扣带回后部被选择性地激活。通过情绪的反复激发,激活的大脑区域从扣带回后回转移到双侧枕叶关联皮层,情绪被习惯化。在恐惧条件语义记忆任务中,左侧颞上回和右侧杏仁核同时被激活。虽然在这些研究中不能对患者进行检查,但这些发现将为今后对精神分裂症症状机制的研究提供一些建议,因为某些类型的妄想可能被解释为情绪判断对受试者认知解释的不成比例的优势。
项目成果
期刊论文数量(52)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
西川 隆: "解離性障害と海馬:解離性障害における記憶の障害と神経機構"臨床精神医学. 30. 1485-1492 (2001)
Takashi Nishikawa:“分离性障碍和海马:分离性障碍中的记忆障碍和神经机制”《临床精神病学》30。1485-1492(2001)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Fumihiko Yasuno: "Functional anatomical study of psychogenic amnesia"Psychiatry Research. 10. 43-57 (2000)
安野文彦:《心因性失忆症的功能解剖学研究》精神病学研究。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Mizuno-Matsumoto Y, Ishijima M, shinosaki K, Nishikawa T, Ukai S, Ikejiri Y, Nakagawa Y, Ishii R, Tokunaga H, Tamura S, Date S, Inouye T, shimojo S, Takeda M: "Transient Global amnesia (TGA) in an MEG Study"Brain Topography. 13. 269-274 (2001)
水野松本 Y、石岛 M、筱崎 K、西川 T、宇井 S、池尻 Y、中川 Y、石井 R、德永 H、田村 S、伊达 S、井上 T、下城 S、武田 M:“短暂性全局失忆症(TGA)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Ukai S, Shinosaki K, Ishii R, Ogawa A, Mizuno-Matsumoto Y, Inouye T, Hirabuki N, Yoshimine T, Robinson SN, Takeda M: "Spatially filtered MEG analysis estimates propagation of cortical activities during the stroop task"Recent Advances in Human Brain Mappin
Ukai S、Shinosaki K、Ishii R、Okawa A、Mizuno-Matsumoto Y、Inouye T、Hirabuki N、Yoshimine T、Robinson SN、Takeda M:“空间过滤 MEG 分析估计了 stroop 任务期间皮质活动的传播”最新进展
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
西川 隆: "新世紀の精神科治療 第6巻 認知の科学と臨床"中山書店. 404 (2003)
西川隆:《新世纪的精神病治疗第6卷:认知科学与临床实践》中山书店404(2003)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
NISHIKAWA Takashi其他文献
NISHIKAWA Takashi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('NISHIKAWA Takashi', 18)}}的其他基金
Social cognitive dysfunctions in chronic schizophrenia and therapeutic method using humor comics.
慢性精神分裂症的社会认知功能障碍及幽默漫画的治疗方法。
- 批准号:
22500470 - 财政年份:2010
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
Sensory Engineering: Investigating Altered and Guided Perception and Hallucination
感官工程:研究改变和引导的感知和幻觉
- 批准号:
AH/Y007638/1 - 财政年份:2024
- 资助金额:
$ 6.53万 - 项目类别:
Research Grant
Understanding, Predicting and Controlling AI Hallucination in Diffusion Models for Image Inverse Problems
理解、预测和控制图像逆问题扩散模型中的 AI 幻觉
- 批准号:
2906295 - 财政年份:2024
- 资助金额:
$ 6.53万 - 项目类别:
Studentship
Targeting the Auditory Control Network with Auditory Control Enhancement (ACE) in Schizophrenia
通过听觉控制增强 (ACE) 治疗精神分裂症的听觉控制网络
- 批准号:
10593386 - 财政年份:2023
- 资助金额:
$ 6.53万 - 项目类别:
The impact of hallucinogens on active sampling and the olfactory bulb
致幻剂对主动采样和嗅球的影响
- 批准号:
10678588 - 财政年份:2023
- 资助金额:
$ 6.53万 - 项目类别:
Real time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects, in clinical high risk individuals
临床高危个体的实时神经反馈、其神经递质基础和治疗效果
- 批准号:
10645480 - 财政年份:2023
- 资助金额:
$ 6.53万 - 项目类别:
Deep Brain Stimulation for Chronic Auditory Hallucinations in Treatment-Resistant Schizophrenia: an early-stage clinical trial
深部脑刺激治疗难治性精神分裂症慢性幻听:一项早期临床试验
- 批准号:
10644871 - 财政年份:2023
- 资助金额:
$ 6.53万 - 项目类别:
Imaging epigenetic dysregulation in the Lewy body dementias with [11C]Martinostat
使用 [11C]Martinostat 对路易体痴呆的表观遗传失调进行成像
- 批准号:
10661239 - 财政年份:2023
- 资助金额:
$ 6.53万 - 项目类别:
Empirical validation of a cerebellar-cortical hallucination circuit
小脑皮质幻觉回路的实证验证
- 批准号:
10543553 - 财政年份:2022
- 资助金额:
$ 6.53万 - 项目类别:
Examining the electroencephalographic fingerprint of default mode network hyperconnectivity for scalable and personalized neurofeedback in schizophrenia
检查默认模式网络超连接的脑电图指纹,以实现精神分裂症的可扩展和个性化神经反馈
- 批准号:
10509002 - 财政年份:2022
- 资助金额:
$ 6.53万 - 项目类别: