The positioning of the hyoid bone under control modulated by the parasympathetic nervous system.

舌骨的定位受副交感神经系统的调节。

• 批准号: 12470451
• 负责人: FURUSAWA Kiyofumi
• 金额: $ 3.65万
• 依托单位: Matsumoto Dental University School of Dentistry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470451/
• 关键词: autonomic nerve; ganglia; upper airway; sympathetic nerve; parasympathetic nerve; 頸神経ワナ; 舌下神経; オトガイ舌骨; 嚥下; 節後ニューロン; シナプス; ラット; 頚神経ワナ; オトガイ舌骨筋

Previous studies have indicated that the geniohyoid (GH) muscle is innervated by efferent axons in the hypoglossal (XII) nerve and the ansa cervicalis. To clarify the physiological significance of this dual innervation of the GH muscle, we examined the properties of the efferent innervation of the rat GH muscle using eleotrophysiologioal and immunohistochenical methods. Recordings from the branch of the XII nerve that innervates the GH muscle (GH.Br) showed that bursts of impulses during fictitious swallowing were conducted via the XII nerve trunk. In contrast, tonic discharges in the GH. Br were conducted via the ansa cervicalis. Tonic activity was abolished in vitro by mecamylamine, an antagonist of the nicotinic acetylcholine receptor (nAChR), and by pirenzepine, an antagonist of the muscarinic M1 receptor. Incubation of isolated XII nerve segments with antisera to vasoactive intestinal peptide, nAChR, and the muscarinic M1 receptor yielded a small number of labeled neurons with each antiserum. All of the labeled neurons had similar diameters and were located approximately 1.5 mm proximal to the bifurcation of the XII nerve into its medial and lateral branches. Our findings indicate that the GH muscle in the rat is innervated by both the somatic and the parasympathetic nervous systems.

以往的研究表明，颏舌骨肌（GH）是由传出轴突在舌下神经（XII）和颈袢的支配。为了阐明GH肌这种双重神经支配的生理意义，我们用电生理和电化学方法研究了大鼠GH肌传出神经支配的特性。来自支配GH肌（GH.Br）的XII神经的分支的记录表明，在虚拟吞咽期间的脉冲串通过XII神经干进行。相反，紧张性放电的GH。经颈袢进行Br检查。强直活性被取消在体外由美加明，烟碱乙酰胆碱受体（nAChR）的拮抗剂，并由哌仑西平，毒蕈碱M1受体的拮抗剂。孵育隔离的第十二神经节段与抗血清血管活性肠肽，乙酰胆碱受体，和毒蕈碱M1受体产生了少量的标记神经元与每个抗血清。所有标记的神经元具有相似的直径，并且位于XII神经分叉到其内侧和外侧分支的近端约1.5 mm处。我们的研究结果表明，生长激素肌肉在大鼠的躯体和副交感神经系统的支配。

项目成果

K.Yasuda, et al.: "Central distribution of neuronal cell bodies innervating the levator veli palatini muscle and associated pattern of myosin heavy chain isoform expression in rat"Brain Research. 968. 80-88 (2003)

K.Yasuda 等人：“大鼠提腭帆肌神经元细胞体的中心分布和肌球蛋白重链亚型表达的相关模式”大脑研究。

K.Yasuda: "Central distribution of neuronal cell bodies innervating the levator veli palatini muscle and associated pattern of myosin heavy chain isoform expression in rat"Brain Research. (in press).

K.Yasuda：“大鼠提腭帆肌神经元细胞体的中央分布和肌球蛋白重链亚型表达的相关模式”大脑研究。

K. Yasuda: "The distribution of respiration-related and swallowing-related motoneurons innervating the rat genioglossus muscle"Somatosensory & Motor Research. 19 (1). 30-35 (2002)

K. Yasuda：“支配大鼠颏舌肌的呼吸相关和吞咽相关运动神经元的分布”体感

K.Yasuda et al.: "The distribution of respiration-related and swallowing-related motoneurons innervating the rat genioglossus muscle"Somatosensory & Motor Research. 19(1). 30-35 (2002)

K.Yasuda 等：“支配大鼠颏舌肌的呼吸相关和吞咽相关运动神经元的分布”体感

K.Yasuda et al.: "Evidence of parasympathetic postganglionic neurons in the rat hypoglossal nerve trunk"Experimental Brain Research. (in press).

K.Yasuda 等人：“大鼠舌下神经干中副交感神经节后神经元的证据”实验脑研究。