Central nervous systems of tongue movement relating upper airway patency

本研究的目的是阐明舌运动与上气道通畅的中枢神经系统，特别是颏舌肌和颏舌骨肌运动神经元。1.颏舌肌和颏舌骨肌运动神经元的中枢分布（辣根过氧化物酶示踪研究）颏舌肌运动神经元的中枢分布在舌下神经核腹内侧亚核的外侧区，距颈前0.7 ~ 1.2mm。结果：1. P物质和5-羟色胺在大鼠生后舌下神经核腹内侧亚核和腹外侧亚核的分布（免疫组织化学分析）使用胚胎（E）第19天和出生后（P）第0、4、7、14、21、28和70天的Wistar大鼠（每个年龄5只大鼠）。舌下神经核腹内侧亚核和腹外侧亚核内P物质和5-羟色胺阳性终末的密度在E19时较低，到P7时逐渐增加，之后逐渐降低（原位杂交）NK 1表达的生后变化，在舌下神经核的腹内侧亚核和腹外侧亚核中未发现5 HT 1A和5 HT 1B受体

The purpose of this study was to clarify the central nervous systems of tongue movement relating upper airway patency, especially genioglossal and geniohyoid motoneurons. Wistar rats were used in this study.1.Central distribution of genioglossal and geniohyoid motoneurons (Horseradish Peroxidase tracing study)The central location of geniglossal motoneurons was observed in the lateral region of the ventromedial subnucleus in the hypoglossal nucleus, extending from 0.7 to 1.2 mm rostral to the obex. The central location of the geniohyoid motoneurons were subsequently observed in the ventrolareral subnucleus of the hypoglossal nucleus.2.Distribution of substance P and serotonin in the postnatal rat ventromedial and ventrolareral subnucleus of the hypoglossal nucleus (Immunohistochemical analysis)Wistar rats at embryonic (E) day 19 and postnatal (P) days 0,4,7,14,21,28 and 70 (five rats at each age) were used. The density of both substance P- and serotonin- immunoreactive terminals in the ventromedial and ventrolareral subnucleus of the hypoglossal nucleus was low at E19, gradually increased until P7 and decreased thereafter.3.Expression of NK1,5HT1A and 5HT1B receptors (In situ hybridization)Postnatal change of expression of NK1,5HT1A and 5HT1B receptors was not recognized in the ventromedial and ventrolareral subnucleus of the hypoglossal nucleus