Central nervous systems of tongue movement relating upper airway patency

与上呼吸道通畅相关的舌头运动的中枢神经系统

• 批准号: 15390626
• 负责人: FURUSAWA Kiyofumi
• 金额: $ 9.15万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390626/
• 关键词: swallowing; respiration; ageing; tongue; シナプス; 呼吸; 舌骨上筋; 脳幹; 神経伝達物質; 神経トレーサー

The purpose of this study was to clarify the central nervous systems of tongue movement relating upper airway patency, especially genioglossal and geniohyoid motoneurons. Wistar rats were used in this study.1.Central distribution of genioglossal and geniohyoid motoneurons (Horseradish Peroxidase tracing study)The central location of geniglossal motoneurons was observed in the lateral region of the ventromedial subnucleus in the hypoglossal nucleus, extending from 0.7 to 1.2 mm rostral to the obex. The central location of the geniohyoid motoneurons were subsequently observed in the ventrolareral subnucleus of the hypoglossal nucleus.2.Distribution of substance P and serotonin in the postnatal rat ventromedial and ventrolareral subnucleus of the hypoglossal nucleus (Immunohistochemical analysis)Wistar rats at embryonic (E) day 19 and postnatal (P) days 0,4,7,14,21,28 and 70 (five rats at each age) were used. The density of both substance P- and serotonin- immunoreactive terminals in the ventromedial and ventrolareral subnucleus of the hypoglossal nucleus was low at E19, gradually increased until P7 and decreased thereafter.3.Expression of NK1,5HT1A and 5HT1B receptors (In situ hybridization)Postnatal change of expression of NK1,5HT1A and 5HT1B receptors was not recognized in the ventromedial and ventrolareral subnucleus of the hypoglossal nucleus

本研究的目的是阐明与上呼吸道通畅相关的舌头运动的中枢神经系统，特别是颏舌骨和颏舌骨运动神经元。本研究采用Wistar大鼠。 1.颏舌运动神经元和颏舌骨运动神经元的中心分布（辣根过氧化物酶示踪研究）颏舌运动神经元的中心位置观察到舌下核腹内侧亚核的外侧区域，从吻侧0.7至1.2毫米延伸到肥胖。随后在舌下核的腹侧亚核中观察到颏舌骨运动神经元的中心位置。2.P物质和血清素在出生后大鼠舌下核腹内侧和腹侧亚核中的分布（免疫组织化学分析）胚胎（E）第19天和出生后的Wistar大鼠 (P)使用第0、4、7、14、21、28和70天（每个年龄的五只大鼠）。舌下核腹内侧和腹侧亚核中P物质和5-羟色胺免疫反应末端的密度在E19时较低，直至P7逐渐增加，此后下降。3.NK1，5HT1A和5HT1B受体的表达（原位杂交）出生后NK1，5HT1A表达的变化 5HT1B 受体在舌下核的腹内侧和腹外侧亚核中未被识别

项目成果

Colocalization of serotonin and substance P in the postnatal rat trigeminal motor nucleus and its surroundings

出生后大鼠三叉神经运动核及其周围血清素和 P 物质的共定位

• 发表时间: 2006
• 期刊: International journal of Developmental neuroscience 24
• 作者: Tanaka;S.;Minami;M.;Murakami;Y.;Ogiwara;T.;et al.;Sakagami H;Hirata A;Matsuura T. et al.;Masaaki Nakamura et al.
• 通讯作者: Masaaki Nakamura et al.

Evidence of parasympathetic postganglionic neurons in the rat hypoglossal nerve trunk

大鼠舌下神经干中副交感节后神经元的证据

• 发表时间: 2003
• 期刊: Experimental Brain Research 153・3
• 作者: Yasuda K;et al.
• 通讯作者: et al.

K.Yasuda, et al.: "Central distribution of neuronal cell bodies innervating the levator veli palatini muscle and associated pattern of myosin heavy chain isoform expression in rat"Brain Research. 968. 80-88 (2003)

K.Yasuda 等人：“大鼠提腭帆肌神经元细胞体的中心分布和肌球蛋白重链亚型表达的相关模式”大脑研究。

K.Yasuda, et al.: "Evidence of parasympathetic postganglionic neurons in the rat hypoglossal nerve trunk"Experimental Brain Research. 153. 302-309 (2003)

K.Yasuda 等人：“大鼠舌下神经干中副交感神经节后神经元的证据”实验脑研究。