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The functional properties of the nerve supplying to muscles around the hyoid bone by using electrophysiological and HRP techniques

使用电生理学和 HRP 技术研究供应舌骨周围肌肉的神经的功能特性

基本信息

批准号：
09470462
负责人：
FURUSAWA Kiyofumi
金额：
$ 4.8万
依托单位：
Matsumoto Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

The previous studies indicate that the geniohyoid (GH) muscle receives its nerve supply via both the hypoglossal nerve and ansa cervicalis. However, the physiologic significance and properties of this dual innervation of the GH muscle have not yet been clarified. We examined the functional properties and distribution of the efferent and afferent components of the nerve supply to the rat GH muscle by using electrophysiological and horseradish peroxidase conjugated with wheat germ agglutinin retrograde labeling techniques. The present study provides several new findings concerning the neurons supplying the GH muscle. It was found that the GH muscle motoneurons related to swallowing are localized in the ventrolateral part of the hypoglossal nucleus. The activities of these motoneurons are conducted via the hypoglossal nerve trunk ; Synaptic transmission exists in the descending course to the GH muscle from the motoneurons located in the vicinity to the central canal, extending from approximately 0.5 to 1.0 mm caudal to the obex. The postsynaptic neurons are present in the region of the bifurcation point into the medial and lateral branched of the hypoglossal nerve. Afferent components from the proprioceptors of the GH muscle travel over the distal portion of the hypoglossal nerve to the ansa cervicalis, and then reach the primary sensory neurons located in the C1 spinal ganglia. The present results provide evidence that the GH muscle plays a significant role in the postural arrangement of the hyoid bone under control dependent on the autonomic nervous and somatic sensory systems.

先前的研究表明，颏舌骨肌（GH）通过舌下神经和颈袢接收神经供应。然而，GH 肌的这种双重神经支配的生理意义和特性尚未阐明。我们通过使用电生理学和辣根过氧化物酶与麦芽凝集素逆行标记技术结合，检查了大鼠 GH 肌肉神经供应的传出和传入成分的功能特性和分布。本研究提供了一些关于供给 GH 肌肉的神经元的新发现。研究发现与吞咽相关的GH肌肉运动神经元位于舌下核的腹外侧部分。这些运动神经元的活动是通过舌下神经干进行的；突触传递存在于从位于中央管附近的运动神经元到 GH 肌肉的下行过程中，从尾部大约 0.5 至 1.0 毫米延伸到 obex。突触后神经元存在于舌下神经内侧和外侧分支的分叉点区域。来自 GH 肌本体感受器的传入成分经过舌下神经的远端部分到达颈袢，然后到达位于 C1 脊神经节的初级感觉神经元。目前的结果提供了证据，表明 GH 肌肉在依赖于自主神经和躯体感觉系统的控制下的舌骨姿势排列中发挥着重要作用。