Research on functional substances from mushrooms showing preventing or curing effects on some diseases

点击翻译按钮获取中文摘要

This project was done under the following subjects.1) Suppressing substances against amyloid-β cytotoxicitySince the mushroom Hericium erinaceum exhibited suppressing activity against Amyloid-β cytotoxicity, we tried to isolate the active principles from the mushroom. As a result, a kind of phosphatidyl ethanolamine was obtained. The structure was determined by spectroscopic methods such as NMR, MS, IR and so on.2) Liver injury preventing substanceBy the screening for liver injury preventing activity of mushrooms, we found that Lentinus edodes, Flammulina velutipes, and Grifola frondosa had potent activities. The isolation of active principles from the mushrooms are now in progress.3) Anti-oxidant, anti-allergy, anti-tumor substancesThe cultured mycelia of Phellinus linteus showed anti-oxidant, anti-allergy, and anti-tumor activities. Isolation of the active principles from the mushrooms are now in progress.4) Matrix metallo-proteinase inhibitorA matrix metallo-proteinase inhibitor was purified from the mushroom Piputoporus betulinus5) Nerve growth factor inducerNerve growth factor inducers were obtained from the mycelia of Hericium erinaceum. The compounds were named as erinacines H and I.