Research on functional substances from mushrooms showing preventing or curing effects on some diseases

蘑菇功能物质研究对某些疾病具有预防或治疗作用

• 批准号: 12490015
• 负责人: KAWAGISHI Hirokazu
• 金额: $ 7.49万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12490015/
• 关键词: mushrooms; liver injury; amyloid-β; anti-allergy; anti-oxidant; マトリックスメタロプロテアーゼ; 疾病予防; 治療; 機能性物質; NGF; 摂食抑制; レクチン

This project was done under the following subjects.1) Suppressing substances against amyloid-β cytotoxicitySince the mushroom Hericium erinaceum exhibited suppressing activity against Amyloid-β cytotoxicity, we tried to isolate the active principles from the mushroom. As a result, a kind of phosphatidyl ethanolamine was obtained. The structure was determined by spectroscopic methods such as NMR, MS, IR and so on.2) Liver injury preventing substanceBy the screening for liver injury preventing activity of mushrooms, we found that Lentinus edodes, Flammulina velutipes, and Grifola frondosa had potent activities. The isolation of active principles from the mushrooms are now in progress.3) Anti-oxidant, anti-allergy, anti-tumor substancesThe cultured mycelia of Phellinus linteus showed anti-oxidant, anti-allergy, and anti-tumor activities. Isolation of the active principles from the mushrooms are now in progress.4) Matrix metallo-proteinase inhibitorA matrix metallo-proteinase inhibitor was purified from the mushroom Piputoporus betulinus5) Nerve growth factor inducerNerve growth factor inducers were obtained from the mycelia of Hericium erinaceum. The compounds were named as erinacines H and I.

1）β-淀粉样蛋白细胞毒性抑制物质的研究由于猴头菌（Hericium erinaceum）具有抑制β-淀粉样蛋白细胞毒性的活性，我们试图从猴头菌中分离有效成分。结果，得到一种磷脂酰乙醇胺。2）抗肝损伤活性物质通过对香菇、金针菇、灰树花抗肝损伤活性的筛选，发现香菇、金针菇、灰树花具有较强的抗肝损伤活性。3）抗氧化、抗过敏、抗肿瘤活性物质经体外培养的香菇菌丝体具有抗氧化、抗过敏、抗肿瘤活性。4）基质金属蛋白酶抑制剂（MMP）4）神经生长因子诱导剂（NGF）5）神经生长因子诱导剂（NGF）6）神经生长因子诱导剂（NGF）7）神经生长因子诱导剂（NGF）8）神经生长因子诱导剂（NGF）9）神经生长因子诱导剂（NGF）10）神经生长因子诱导剂（NGF）10）诱导剂（NGF化合物被命名为erinacines H和I。

项目成果

Kawagishi, H.: "Alectin from an edible mushroom Pleurotus ostreatus as a food in take-suppressing substance"Biochim. Biophys. Acta. 1474. 299-308 (2000)

Kawagishi, H.：“来自食用蘑菇平菇的凝集素作为抑制物质的食物”Biochim。

河岸洋和(分担): "キノコとカビの基礎科学とバイオ技術"アイピーシー. 564 (2002)

Hirokazu Kawagishi（贡献者）：“蘑菇和霉菌的基础科学和生物技术”IPC 564 (2002)。

Kawagishi H, Suzuki H, Watanabe H, Nakamura H, Sekiguchi T, Murata T, Usui T, Sugiyama K, Suganuma H, Inakuma T, Ito K, Hashimoto Y, Ohnishi-Kameyama M and Nagata T.: "A lectin from an edible mushroom pleurotus ostreatus as a food intake-suppressing subst

Kawagishi H、Suzuki H、Watanabe H、Nakamura H、Sekiguchi T、Murata T、Usui T、Sugiyama K、Suganuma H、Inakuma T、Ito K、Hashimoto Y、Ohnishi-Kameyama M 和 Nagata T.：“来自

Kawagishi H, Miyazawa T, Kume H, Arimoto Y and Inakuma T: "Aldehyde dehydrogenase inhibitors from the mushroom clitocybe clavipes"J. Nat. Prod.. 65 (11). 1712-1714 (2002)

Kawagishi H、Miyazawa T、Kume H、Arimoto Y 和 Inakuma T：“来自蘑菇 clitocybe clavipes 的醛脱氢酶抑制剂”J。

Kawagishi, H. etal.: "Purification and characterization of a lectin from the mushroom Mycoleptodonoides aitchisonii"Phytochemistry. 56. 53-58 (2001)

Kawagishi, H. 等人：“来自蘑菇 Mycoleptodonoides aitchisonii 的凝集素的纯化和表征”植物化学。