Development of Sustainable Highly Selective Electrofluorination Using Electrocatalysis

利用电催化开发可持续的高选择性电氟化

• 批准号: 12555252
• 负责人: FUCHIGAMI Toshio
• 金额: $ 5.7万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12555252/
• 关键词: Electrocatalysis; Mediator; Triarylamine; Diamonde electrode; Bio active compound; Electrochemical fluorination; Fluorodesulfurization; Organic electrolyte for Libattery; メデイエーター; 生理活性物質; ベンゾイルフルオリド; 複素環化合物; 含フッ素β-ラクタム; ジフルオロメチレン基; 含フッ素環状カーボ

Selective fluorination of organic compounds is highly useful for development of medicines, agrochemicals, and functional materials. However, the fluorination methods have not been well developed. Therefore, we aimed the following projects through the new development of sustainable highly selective electrofluorination using electrocatalysis.1) Development of organic electrolytes for high performance rechargeable Li batteries2) Development of fluorinated biologically active compounds usinig electrocatalytic fluorodesulfurization3) Selective electrofluorination of organic compounds using diamonds electrodes4) Development of fluorinated ethers as flon substituentsWe have mostly achieved above projects and the results seem to be useful for future study on selective fluorination of various organic molecules.

有机化合物的选择性降解对于药物、农用化学品和功能材料的开发非常有用。然而，这些方法还没有得到很好的发展。因此，我们认为，我们的目标是通过使用电催化的可持续高选择性电解质的新开发实现以下项目：1）开发高性能可充电锂电池的有机电解质2）使用电催化氟脱硫开发氟化生物活性化合物3）使用金刚石电极选择性电解有机化合物4）氟代醚类化合物的研究进展以上工作已基本完成，对今后研究各种有机分子的选择性取代反应具有一定的参考价值。

项目成果

DAISUKE BABA: "Regio-and Diastereoselective Anodic Fluorination of Thiazolidines"Journal of Organic Chemistry. 66. 7020-7024 (2001)

DAISUKE BABA：“噻唑烷的区域和非对映选择性阳极氟化”有机化学杂志。

Toshio Fuchigami: "Electrolytic Partial Fluorination of Organic Compounds.44. Anodic gem-Difluoro desulfurization Using Triarylamine Mediators"J. Electroanal. Chem.. 507. 30-33 (2001)

Toshio Fuchigami：“有机化合物的电解部分氟化。44。使用三芳胺介体的阳极二氟脱硫”J。

Daisuke Baba: "Electrolytic Partial Fluorination of Organic Compound. 52. Regio- and Diastereoselective Anodic Fluorination of Thiazolidines"J. Org. Chem.. 66. 7020-7024 (2001)

Daisuke Baba：“有机化合物的电解部分氟化。52。噻唑烷的区域和非对映选择性阳极氟化”J。

TOSHIO FUCHIGAMI: "ORGANIC ELECTROCHEMISTRY. 4TH EDITION"MARCEL DEKKER. 15 (2001)

Toshio Fuchigami：“有机电化学。第四版”MARCEL DEKKER。

TOSHIO FUCHIGAMI: "Indirect Anodic Monofluorodesulfurization of β-Phenylsulfenyl β-lactams Using a Triarylamine Mediator"Synlett.. 1269-1271 (2001)

TOSHIO FUCHIGAMI：“使用三芳胺介体对 β-苯基硫基 β-内酰胺进行间接阳极单氟脱硫”Synlett.. 1269-1271 (2001)