Development of Novel Asymmetric Fluorination Using Electrolysis

点击翻译按钮获取中文摘要

Chiral organofluorine compounds are highly useful for medicines, agrochemicals, and functional materials. Optical resolution, biological and chiral fluorobuilding block methods have been mainly employed so far. Asymmetric fluorination seems to be the mostideal method for the preparation of chiral organofluorine compounds. However, studies on asymmetric fluorination have been limited and there have been few successful examples.On the other hand, we have recently developed versatile selective anodic fluorination of organic compounds.With these in mind, asymmetric anodic fluorination using various chiral induction methods has been attempted as follows :1) Diastereoselective Anodic Fluorination of Thiazolidines2) Highly Diastereoselective Anodic Fluorination of 3, 3, 3-Trifluoro-2-methoxypropyl Sulfides3) Diastereoselective Anodic Fluorination of a-Phenylthioacetates Having Chiral AuxiliariesWe have achieved above three projects and the results obtained in these projects would be highly useful for further studies on asymmetric anodic fluorination of various organic molecules.