Physiological function of the non-pungent capsaicin analog, and application to novel functional food stuffs.

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The physiological effects of CH-19Sweet and capsiate were investigated. We showed that CH19Sweet increased thermogenesis and energy expenditure in human. CH19Sweet was given to 11 healthy volunteers and their core body temperature, forehead and neck temperature were significantly higher than control group. Respiratory gas analysis indicated that subjects given the CH19 Sweet and capsiate increased in the oxygen consumption and fat metabplism. Power spactral analysis of heart rate variability shoewd that autonomic nerve activity was higher in the experimental group. Body fat accumulation in mice was significant decreased when we gave CH19Sweet or capsiate for 2 weeks suggested that stimulation of synpathetic nerve activity and increment of body temperature enhanced body fat metabolism and body fat consumption. These findings indicated that CH19Sweet and capsiate would be a functional materials for suppression of body fat accumulation.