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Targeting Hyperthermia by RF Inductive Heating for Selective Heating of Cancer

通过射频感应加热实现癌症选择性加热的靶向热疗

基本信息

批准号：
12558106
负责人：
SHINKAI Masashige
金额：
$ 8.32万
依托单位：
THE UNIVERSITY OF TOKYO (2001-2002)Nagoya University (2000)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

1. Improvement of RF specific heating deviceCharacteristics of particulate heating mediators in radiofrequency (RF) capacitive hyperthermia were investigated. Four ferromagnetic ferrite particles (Cu(II)Fe(III)2O3, Mg(II)Fe(III)2O3, Mn(II)Fe(III)2O3, and Ni(II)Fe(III)2O3) in addition to magnetite particles and other non-ferromagnetic metal oxide particles (a-Fe2O3, a-Alumina, Ag(II)O, and ZnO) were tested using 8 MHz RF heating device. As a result, ferromagnetic particles could generate heat specifically in RF capacitive, but non-ferromagnetic particles could not. In addition, dispersiblity of particles was an important parameter for heat generation.2. Preparation of biocompatible heating mediatorMagnetite needle, in which magnetite particles are molded into needle-shape, was developed and we applied it as a heating mediator for intracellular hyperthermia. We investigated the hyperthermic effect on solid subcutaneous gliomas in the femoral region of female F344 rats. The tumor tissue completely disappeared in many rats exposed to a magnetic field, and the needles were simply administered through a syringe. The magnetite needle will be a novel and potentially effective mediator of hyperthermia that can be used to treat other malignant solid tumors without severe side effects.3. Specific heating and effect of magnetic particles in RF heatingMagnetite cationic liposomes (MCLs) were injected in a rat tumor on femur and an 8 MHz-RF capacitive heating was applied to the rat under the conditions of 'mild heating'. The MCLs-injected tumor was heated over 43℃ whereas it was only heated until 41℃ in the case of the rats injected no MCLs. The necrotic area of tumor was observed in the heated rat.4. Safety of heating mediatorNo toxico effect of heating mediator was observed in all invetigations.

1.研究了射频电容热疗中微粒加热介质的特性。除了磁铁矿颗粒和其它非铁磁性金属氧化物颗粒（α-Fe 2 O3、α-氧化铝、Ag（II）O和ZnO）之外，还使用8 MHz RF加热装置测试了四种铁磁性铁氧体颗粒（Cu（II）Fe（III）2 O3、Mg（II）Fe（III）2 O3、Mn（II）Fe（III）2 O3和Ni（II）Fe（III）2 O3）。因此，铁磁颗粒可以在RF电容中产生热量，而非铁磁颗粒不能。此外，颗粒的分散度是影响发热量的重要参数.生物相容性热介质的制备将磁铁矿颗粒成型为针形，研制出磁铁矿针，并将其作为细胞内热疗的热介质。我们研究了高温对雌性F344大鼠股骨区域实体皮下胶质瘤的影响。许多暴露在磁场中的大鼠的肿瘤组织完全消失，并且只需通过注射器注射针头即可。磁铁针将是一种新的和潜在的有效的热疗介质，可用于治疗其他恶性实体肿瘤，而没有严重的副作用。射频加热中的比热及磁性粒子效应将磁性阳离子脂质体（MCLs）注入大鼠股骨肿瘤内，在“温和加热”条件下对大鼠施加8 MHz的射频电容加热。注射MCL的肿瘤加热至43℃以上，而未注射MCL的大鼠仅加热至41℃。热处理组大鼠肿瘤坏死面积明显增加.加热介质的安全性所有研究均未观察到加热介质的毒性作用。