COMPARATIVE STUDY ON TRADITIONAL MEDICINES OF TURKIC PEOPLE (2)

突厥民族传统医药比较研究（二）

• 批准号: 12576027
• 负责人: HONDA Gisho
• 金额: $ 9.66万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12576027/
• 关键词: CENTRAL ASIA; TURKIC PEOPLE; TRADITIONAL MEDICINES; MEDICINAL PLANTS; PHYTOCHEMISTRY; LICORICE; フィールドワーク; ウズベキスタン; カブフスタン; カザフスタン

This research was the secondary project of the field survey on traditional medicines of Turkic people in Central Asia. We performed;(1) Field survey on traditional and/or folk medicines and on medicinal plants of Uzbekistan in the area of Tardkurgan and Namangan which are along Tienshan-North road of the Silk Road,(2) Phytochemical analysis of plant materials collected in the field survey. Finally, specimens of folk medicines and medicinal plants collected for the project (1) were counted up to 400, and results of (2) were published in 26 of scientific papers during these 3 years.As for specimens collected for (1), most of the origins of them were identified. Not a few herb samples were turned out to be affected by European and Russian medicines. And licorice samples, aerial and underground parts and also seeds, were collected in the area from Almaty (Kazakhstan) to Tashkent (Uzbekistan).Vegetation area of licorice plants, Glycyrrhiza uralensis and G. glabra, was wide, and it turned out to be interesting that there were many licorice plants which was supposed to be a crosshybridized species between G. uralensis and G. glabra. This presumptive hybrids might be good samples for the phylogenetic relationship between these two species.As for the phytochemical studies of (2), 13 species of Gentiana olivieri, Inula macrophylla, Ferula foetida, F. kuhistanica, F. pallida, F. penninervis, F. sumble, Rheum maximowiczii, Scutellaria hematochlora, Prangos tschimganica, P. pabularia, Phlomis spinidens, Dracocephalum komarovi, were analyzed for their characteristic components as well as their biological activities, and finally, more than 100 secondary metabolites including many new compounds, such as terpenoids (sesquiterpenes, diterpenes), coumarines, flavonoids, and sulphate-containing compounds, had been isolated and were determined their structures.

本研究是中亚突厥民族传统医药实地调查的二级项目。我们表演，（1）对丝绸之路沿着天山北路的塔尔德库尔干和纳曼干地区乌兹别克斯坦传统和/或民间药物以及药用植物进行实地调查，（2）对实地调查中收集的植物材料进行植物化学分析。最后，为项目（1）采集的民间药物和药用植物标本达400余份，项目（2）的研究成果在3年中发表在26篇学术论文中，对于项目（1）采集的标本，大部分已查明其来源。不少草药样品被证明受到欧洲和俄罗斯药物的影响。在哈萨克斯坦的阿拉木图至乌兹别克斯坦的塔什干地区采集了甘草的地上部分、地下部分和种子。glabra之间的杂交种，并且发现有许多甘草属的植物，这是一个有趣的现象。uralensis和G.光滑的在植物化学研究中，对龙胆、大叶旋覆花、阿魏、黄毛龙胆、黄毛kuhistanica，F. pallida，F. penninervis，F.本文对大花大黄、血绿紫茎泽兰、金雀花、白雀花、刺糙苏、香青兰等5种植物的特征成分和生物活性进行了分析，最终鉴定出100多种次生代谢产物，其中包括萜类化合物等许多新化合物（倍半萜、二萜）、香豆素、黄酮类化合物和含硫酸根的化合物，并测定了它们的结构。

项目成果

Y. Shikishima, et al.: "Sesquiterpenes from Ferula penninervis"J. Nat. Prod. 65 (12). 1897-1903 (2002)

Y. Shikishima 等人：“来自阿魏的倍半萜”J.

Y.Shikishima, Y.Takaishi, G.Honda, M.Ito, Y.Takeda, M.Tori et al.: "Sesquiterpenes from Ferula penninervis"J. Nat. Prod.. 65(12). 1897-1903 (2002)

Y.Shikishima、Y.Takaishi、G.Honda、M.Ito、Y.Takeda、M.Tori 等人：“来自阿魏的倍半萜”J.

Y.Takeda, N.Isai, T.Masuda, H.Otsuka, G.Honda, Y.Takaishi: "A new megastigmane glucoside from Phlomis spinidens"Natural Medicines. 56(5). 200-203 (2002)

Y.Takeda，N.Isai，T.Masuda，H.Otsuka，G.Honda，Y.Takaishi：“来自Phlomis spinidens的新巨豆豆苷”天然药物。

K.Tamemoto et al.: "An unusual sesquiterpene drivative from Ferula kuhistanica"J. Nat. Prod.. 65(9). 1323-1324 (2002)

K.Tamemoto 等人：“一种来自阿魏的不寻常的倍半萜衍生物”J.

本多義昭: "ハーブ・スパイス・漢方薬 -シルクロードくすり往来-"丸善. 104 (2001)

本田义明：“草药、香料和中药 - 丝绸之路医药交通”Maruzen 104 (2001)。