Ozone-induced graft polymerization of glycidyl methacrylate for preparation of polymer microspheres with a potential of separation and purification of polyunsaturated fatty acids

臭氧诱导甲基丙烯酸缩水甘油酯接枝聚合制备具有分离纯化多不饱和脂肪酸潜力的聚合物微球

• 批准号: 13450320
• 负责人: KITAMURA Yoshiro
• 金额: $ 9.41万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13450320/
• 关键词: Polymer microsphere; Ozone-induced graft polymerization; Surface treatment; Polyunsaturated fatty acids; Glycidyl, methacrylate; Separation and purification; Adsorption; Dispersion polymerization; 高分子微粒子; 操作条件; 微粒子調製プロセス; 微粒子プロセス

From our previous research, we proposed the preparation method of polymer microspheres with an affinity for polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaacetic acid (EPA). In that study, the synthesis route to endow affinity to polymer microspheres bearing epoxy group on their surface was designed.In this research, we planned a new design for the preparation of polymer microspheres with higher potential on adsorption of polyunsaturated fatty acids. That is to say, the experiment was conducted to prepare polymer microspheres which had more sites for Ag+ adsorption by ozone-induced graft polymerization of glycidyl methacrylate on monodispersed polystyrene microspheres produced by dispersion polymerization.At first, the equipment for ozone exposure of the prepared polymer microspheres was constructed using an advanced rotary evaporator reactor. Flask with four baffle plates was adopted in order polymer microspheres to be well-dispersed in ozone atmosphere. … More After the exposure of polymer microsphere in the equipment, the graft polymerization of glycidyl methacrylate was conducted in a sealed glass tube or a four-necked round bottom flask. As a result, the standard recipe and protocol was determined.Secondly, we tried to clarify the effect of process parameters on formation of grafted polymer layer on polystyrene microspheres. In this study, we varied the parameter of treatment time of ozone-exposure, graft polymerization time, polymerization temperature, monomer concentration and polymerization medium as process parameters. It was found from this experiment that the treatment time of ozone-exposure and graft polymerization time enhanced the formation of grated poly(glycidyl methacrylate) layer, whereas no change was observed by change of polymerization medium. The adequate concentration of glycidyl methacrylate was found to be 5 vol% and more addition of monomer induced the formation of poly(glycidyl methacrylate) microspheres in solution simultaneously. Less

在前期研究的基础上，我们提出了一种对二十二碳六烯酸（DHA）和二十碳五乙酸（EPA）等多不饱和脂肪酸具有亲和性的高分子微球的制备方法。在本研究中，我们设计了一条合成路线，使表面带有环氧基团的聚合物微球具有亲和性，从而为制备对多不饱和脂肪酸具有更高吸附潜力的聚合物微球提供了新的设计思路。本实验采用臭氧引发甲基丙烯酸缩水甘油酯在分散聚合法制备的单分散聚苯乙烯微球上进行接枝聚合，制备具有更多Ag+吸附位点的聚合物微球。为了使聚合物微球在臭氧气氛中得到良好的分散，采用了四挡板烧瓶。 ...更多信息 聚合物微球在设备中暴露后，在密封玻璃管或四颈圆底烧瓶中进行甲基丙烯酸缩水甘油酯的接枝聚合。其次，研究了工艺参数对聚苯乙烯微球表面接枝聚合物层形成的影响。在本研究中，我们改变臭氧暴露处理时间、接枝聚合时间、聚合温度、单体浓度和聚合介质作为工艺参数。实验结果表明，臭氧处理时间和接枝聚合时间对接枝聚甲基丙烯酸缩水甘油酯层的形成有促进作用，而聚合介质的改变对接枝聚甲基丙烯酸缩水甘油酯层的形成没有影响。发现合适的甲基丙烯酸缩水甘油酯的浓度为5体积%，并且同时加入更多的单体诱导聚（甲基丙烯酸缩水甘油酯）微球在溶液中的形成。少