Structure and function of ryanodine receptor

在可兴奋的细胞类型中，从去极化到细胞内Ca 2+升高的信号转换需要细胞表面Ca 2+通道和细胞内Ca 2+释放通道之间的功能耦合。在本项目中，我们的研究小组集中在（i）Ryanodine受体亚型通道的生理调节，（ii）junctophilin亚型的生理作用（junctophilins有助于在可兴奋细胞中观察到的连接膜复合物的形成），（iii）参与细胞内Ca 2+储存功能的新膜蛋白的鉴定。这些研究的主要发现是ryanodine受体对中枢神经系统学习和记忆的贡献，junctophilins对某些神经元运动协调的贡献，以及mitsugumin53作为横纹肌中一种新的膜蛋白的鉴定。

In excitable cell types, the signal conversion from depolarization to intracellular Ca2+ rise requires functional coupling between cell-surface Ca2+ channels and intracellular Ca2+ release channels. In this project, our research group focused on (i) the physiological regulation of ryanodine receptor subtype channels, (ii) the physiological roles of junctophilin subtypes (junctophilins contribute to the formation of junctional membrane complexes observed in excjtable cells), (iii) identification of new membrane proteins taking part in functions of intracellular Ca2+ stores. Major findings in the studies are contribution of ryanodine receptors to learning and memory in the central neurvous system, contribution of junctophilins to motorcoordination in certain neurons, and identification of mitsugumin53 as a novel membrane protein in striated muscles.