Roles of novel intracellular ion channels
Roles of novel intracellular ion channels
批准号:
20249004
负责人:
TAKESHIMA Hiroshi
金额:
$28.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Our group recently identified the TRIC channel and mitsugumin 23 (MG23) as novel intracellular ion channels, and focused on their structure-function relationships and physiological roles in this study. We defined electrophysiological characteristics of TRIC channel subtypes in single channel measurements and their essential physiological functions in alveolar epithelial and skeletal muscle cells using knockout mice. Moreover, we also clarified the three-dimentional volume and cation-specific channel feature of MG23 in single-particle imaging and single channel monitoring, respectively.
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DOI:
10.1093/cvr/cvm019
发表时间:
2008-01-15
期刊:
CARDIOVASCULAR RESEARCH
影响因子:
10.8
作者:
[Shimura, Miei, Minamisawa, Susumu, Ishikawa, Yoshihiro]
通讯作者:
Ishikawa, Yoshihiro
DOI:
10.4161/chan.3.1.7571
发表时间:
2009-01
期刊:
Channels (Austin, Tex.)
影响因子:
--
作者:
[Masumiya H, Asaumi Y, Nishi M, Minamisawa S, Adachi-Akahane S, Yoshida M, Kangawa K, Ito K, Kagaya Y, Yanagisawa T, Yamazaki T, Ma J, Takeshima H]
通讯作者:
Takeshima H
Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP
兔重组 RyR2 的单通道表征揭示了生理浓度 ATP 的新失活特性
DOI:
--
发表时间:
2008
期刊:
J. Membr. Biol 65
影响因子:
--
作者:
[Stewart R, Song L, Carter SM, Sigalas C. Zaccai NR, et.al.]
通讯作者:
et.al.
DOI:
10.1016/j.bbrc.2010.01.013
发表时间:
2010-02
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[T. Yamazaki;Nozomi Sasaki;M. Nishi;H. Takeshima]
通讯作者:
T. Yamazaki;Nozomi Sasaki;M. Nishi;H. Takeshima
TRIC channel subtypes and SR/ER Ca^<2+> release.
TRIC 通道亚型和 SR/ER Ca^<2> 释放。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takeshima, H.]
通讯作者:
H.
共 21 条
Counter ion movement during Ca2+ release
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批准号:24657133
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.66万
-
财政年份:2012
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负责人:TAKESHIMA Hiroshi
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依托单位:
Study of TRIC and MG23 channels
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批准号:23240055
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.62万
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财政年份:2011
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负责人:TAKESHIMA Hiroshi
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依托单位:
Identification of muscular senescence-related genes
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批准号:22659066
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.98万
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财政年份:2010
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负责人:TAKESHIMA Hiroshi
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依托单位:
Channel micro-assembly in junctional membrane complexes
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批准号:17081001
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$44.42万
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财政年份:2005
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负责人:TAKESHIMA Hiroshi
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依托单位:
A study on the molecular hasis of intracellular Ca^<2+> stores
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批准号:15109005
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$72.72万
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财政年份:2003
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负责人:TAKESHIMA Hiroshi
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依托单位:
Structure and function of ryanodine receptor
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批准号:13470028
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
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财政年份:2001
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负责人:TAKESHIMA Hiroshi
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依托单位:
Molecular contraction of Ca^<2+> signaling
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批准号:11470022
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$2.5万
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财政年份:1999
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负责人:TAKESHIMA Hiroshi
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依托单位:
Nociceptin receptor antagonist
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批准号:11559005
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.15万
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财政年份:1999
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负责人:TAKESHIMA Hiroshi
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依托单位:
Structure and function of ryanodine receptors
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批准号:09470022
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1997
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负责人:TAKESHIMA Hiroshi
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依托单位:
Functional analysis of ryanodine receptor using molecular genetic technique
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批准号:08457025
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.22万
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财政年份:1996
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负责人:TAKESHIMA Hiroshi
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依托单位:
Molecular biological studies of ryanodine receptor/calcium release channel
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批准号:06454150
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.48万
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财政年份:1994
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负责人:TAKESHIMA Hiroshi
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依托单位: