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Roles of novel intracellular ion channels

Roles of novel intracellular ion channels
新型细胞内离子通道的作用
批准号:
20249004
负责人:
TAKESHIMA Hiroshi
金额:
$28.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

TAKESHIMA Hiroshi的其他基金

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中文摘要
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英文摘要
Our group recently identified the TRIC channel and mitsugumin 23 (MG23) as novel intracellular ion channels, and focused on their structure-function relationships and physiological roles in this study. We defined electrophysiological characteristics of TRIC channel subtypes in single channel measurements and their essential physiological functions in alveolar epithelial and skeletal muscle cells using knockout mice. Moreover, we also clarified the three-dimentional volume and cation-specific channel feature of MG23 in single-particle imaging and single channel monitoring, respectively.
期刊论文(28)
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科研奖励(0)
会议论文
DOI: 10.1093/cvr/cvm019
发表时间: 2008-01-15
期刊: CARDIOVASCULAR RESEARCH
影响因子: 10.8
作者: [Shimura, Miei, Minamisawa, Susumu, Ishikawa, Yoshihiro]
通讯作者: Ishikawa, Yoshihiro
DOI: --
发表时间: 2008
期刊: J. Membr. Biol 65
影响因子: --
作者: [Stewart R, Song L, Carter SM, Sigalas C. Zaccai NR, et.al.]
通讯作者: et.al.
DOI: 10.4161/chan.3.1.7571
发表时间: 2009-01
期刊: Channels (Austin, Tex.)
影响因子: --
作者: [Masumiya H, Asaumi Y, Nishi M, Minamisawa S, Adachi-Akahane S, Yoshida M, Kangawa K, Ito K, Kagaya Y, Yanagisawa T, Yamazaki T, Ma J, Takeshima H]
通讯作者: Takeshima H
DOI: 10.1016/j.bbrc.2010.01.013
发表时间: 2010-02
期刊: Biochemical and biophysical research communications
影响因子: 3.1
作者: [T. Yamazaki;Nozomi Sasaki;M. Nishi;H. Takeshima]
通讯作者: T. Yamazaki;Nozomi Sasaki;M. Nishi;H. Takeshima
21
    Counter ion movement during Ca2+ release
    • 批准号:
      24657133
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.66万
    • 财政年份:
      2012
    • 负责人:
      TAKESHIMA Hiroshi
    • 依托单位:
    Study of TRIC and MG23 channels
    • 批准号:
      23240055
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.62万
    • 财政年份:
      2011
    • 负责人:
      TAKESHIMA Hiroshi
    • 依托单位:
    Identification of muscular senescence-related genes
    • 批准号:
      22659066
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.98万
    • 财政年份:
      2010
    • 负责人:
      TAKESHIMA Hiroshi
    • 依托单位:
    Channel micro-assembly in junctional membrane complexes