Roles of novel intracellular ion channels

本课题组最近发现TRIC通道和Mitsugumin 23（MG 23）是新的细胞内离子通道，并对其结构功能关系和生理作用进行了研究。我们定义了TRIC通道亚型在单通道测量中的电生理特征及其在使用敲除小鼠的肺泡上皮细胞和骨骼肌细胞中的基本生理功能。此外，我们还阐明了MG 23在单粒子成像和单通道监测中的三维体积和阳离子特异性通道特征。

Our group recently identified the TRIC channel and mitsugumin 23 (MG23) as novel intracellular ion channels, and focused on their structure-function relationships and physiological roles in this study. We defined electrophysiological characteristics of TRIC channel subtypes in single channel measurements and their essential physiological functions in alveolar epithelial and skeletal muscle cells using knockout mice. Moreover, we also clarified the three-dimentional volume and cation-specific channel feature of MG23 in single-particle imaging and single channel monitoring, respectively.