Channel micro-assembly in junctional membrane complexes

本项目的目的是了解质膜和内/肌浆网之间的连接膜复合物中通道串扰的分子基础。特别是，本项目重点关注i)亲结膜蛋白亚型作为产生连接膜复合物的蛋白的生物学作用，ii)在缺乏亲结膜蛋白的敲除小鼠中观察到的生理异常，iii)由亲结膜蛋白突变引起的人类疾病，以及iv)支持亲结膜蛋白介导的通道串扰的新机制。

The aim of this project is to understand the molecular basis of channel crosstalk in junctional membrane complexes between the plasma membrane and the endo-/sarcoplasmic reticulum. In particular, this project focused on i) biological roles of junctophilin subtypess as proteins producing junctional membrane complexes, ii) physiological abnormalities observed in knockout mice lacking junctophilins, iii) human diseases caused by mutated junctophilins, and iv) the new mechanisms supporting the junctophilin-mediated channel crosstalk.