Channel micro-assembly in junctional membrane complexes

本项目的目的是了解质膜和内质网/肌浆网之间连接膜复合体中通道串扰的分子基础。具体地说，这个项目集中在：1)连接蛋白亚型作为产生连接膜复合体的蛋白质的生物学作用；2)在缺乏连接蛋白的基因敲除小鼠中观察到的生理异常；3)由连接蛋白突变引起的人类疾病；以及4)支持连接蛋白介导的通道串扰的新机制。

The aim of this project is to understand the molecular basis of channel crosstalk in junctional membrane complexes between the plasma membrane and the endo-/sarcoplasmic reticulum. In particular, this project focused on i) biological roles of junctophilin subtypess as proteins producing junctional membrane complexes, ii) physiological abnormalities observed in knockout mice lacking junctophilins, iii) human diseases caused by mutated junctophilins, and iv) the new mechanisms supporting the junctophilin-mediated channel crosstalk.