Genetic polymorphisms related to health practice and their effects on health biomarkers

与健康实践相关的基因多态性及其对健康生物标志物的影响

• 批准号: 13470081
• 负责人: TAKESHITA Tatsuya
• 金额: $ 9.09万
• 依托单位: Wakayama Medical University (2002-2003)Osaka University (2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470081/
• 关键词: genotype; aldehyde dehydrogenase; acetaldehyde; alcohol; lifestyle; lifestyle-relate diseases; stress; colorectal polyp; 健康行動; アルコール脱水素酵素

We examined associations of genetic and environmental factors with development of multiple colorectal polyps. The study subjects included 200 cases with multiple colorectal polyps and 150 controls. Genetic factors included genetic polymorphisms in ADH2,ALDH2,CYP1A 1,GSTM1, and NA T2 genes. We obtained information on the subjects lifestyles through the questionnaire method. Analyses on the interactive effects of genetic and environmental factors on colorectal polyps are going. A weak interactive effects of the ALDH2 genotypes and alcohol intake was observed.We also examined contributions of the ALDH2 genotypes, psychosocial stress to problem drinking in 700 male subjects working at a middle-sized enterprise. We measured psychosocial stress using a questionnaire assessing effect-reward imbalance. We used popular scales for problem alcohol drinking ; CAGE and AUDIT. We found a significant relationship between psychosocial stress and problem alcohol drinking.

我们研究了遗传和环境因素与多种结直肠息肉的发展的关联。该研究对象包括200例有多个大肠息肉和150个对照的病例。遗传因素包括ADH2，ALDH2，CYP1A 1，GSTM1和Na T2基因中的遗传多态性。我们通过问卷法获得了有关主题生活方式的信息。对遗传因素和环境因素对大肠息肉的互动效应的分析正在进行中。观察到了ALDH2基因型和酒精摄入量的较弱的互动效应。我们还研究了ALDH2基因型的贡献，对在中型企业工作的700名男性受试者中饮酒的社会心理压力对饮酒的贡献。我们使用问卷评估效果 - 奖励失衡来测量社会心理压力。我们使用流行的量表来饮酒。笼子和审核。我们发现社会心理压力与饮酒问题之间存在显着关系。

项目成果

Nakamoto I, Morimoto K, Takeshita T, Toda M: "Correlation between Saliva Glycated and Blood Glycated Proteins"Environ Health Prev Med. 8. 95-99 (2003)

Nakamoto I、Morimoto K、Takeshita T、Toda M：“唾液糖化蛋白与血液糖化蛋白之间的相关性”Environ Health Prev Med。

Lu, Y.Q.: "Effects of (-)-epigallocatechin gallate (EGCG) on DNA strand breaks as evaluated by single-cell gel electrophoresis (SCG) in human lymphocytes"Environ Health Prev Med. 5. 150-154 (2001)

Lu, Y.Q.：“通过单细胞凝胶电泳 (SCG) 评估人类淋巴细胞中 (-)-表没食子儿茶素没食子酸酯 (EGCG) 对 DNA 链断裂的影响”Environ Health Prev Med。

Takeshita, T.: "Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students."Alcohol Clin Exp Res. 25. 1264-1269 (2001)

Takeshita, T.：“日本男大学生乙醇暴露后 ADH2 基因型与皮肤反应的关联。”酒精临床实验研究。

Obata A: "Application of specific brain function evaluation by optical topography."Environ Health Prev Med. 7. 29-32 (2003)

Obata A：“光学地形图在特定脑功能评估中的应用。”Environ Health Prev Med。

Li, D.: "Arsenic induces DNA damage via reactive oxygen species in human cells"Environ Health Prev Med. 5. 27-32 (2001)

Li, D.：“砷通过人体细胞中的活性氧诱导 DNA 损伤”Environ Health Prev Med。