Alcohol metabolism and disease risk in Asians: Examining the impact of personalized phenotypic/genotypic feedback and motivational processes on early drinking trajectories
亚洲人的酒精代谢和疾病风险:检查个性化表型/基因型反馈和动机过程对早期饮酒轨迹的影响
基本信息
- 批准号:10404917
- 负责人:
- 金额:$ 15.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcculturationAcetaldehydeAcetatesAddressAffectAlcohol consumptionAlcohol dehydrogenaseAlcoholic beverage heavy drinkerAlcoholsAllelesAntacidsAntihistaminesAsianAsian ancestryAsian populationBehavioral MechanismsBenefits and RisksCancer EtiologyCarcinogensCommunicationCommunitiesControl GroupsDNADataDiagnosisDiseaseEast AsianEnvironmentEnzymesEsophagusEthanol MetabolismExpectancyExposure toFeedbackFlushingFocus GroupsFrequenciesFutureGenesGeneticGenotypeGrowthHead and Neck CancerHealth PromotionHealth behaviorHeavy DrinkingIncentivesIndividualInformation TechnologyInterventionJapaneseKnowledgeLeadLightMalignant NeoplasmsMalignant neoplasm of esophagusMediatingMediationMetabolismModelingNamesOnline SystemsOutcomeParticipantPathway interactionsPersonsPhenotypePreventionProtocols documentationRandomizedReportingResearchRiskRisk BehaviorsRoleSample SizeSamplingSecureSelf EfficacyServicesSiteStudentsSubgroupSurveysSyndromeTestingTimeTrainingTranslatingUniversitiesVariantVisitWorkacetaldehyde dehydrogenasealcohol expectancyalcohol involvementalcohol riskalcohol use disorderalcohol use initiationaldehyde dehydrogenasesattentional controlattenuationbasebehavior changebrief interventioncancer geneticscancer preventioncancer riskcohortcollegecollege drinkingcomparison groupcomputerizeddesigndisorder riskdrinkingdrinking onsetearly drinkingeffective interventionesophageal squamous cell cancerexperiencegenetic risk factorgenetic varianthigh riskhigh risk populationimprovedinnovationinsightintervention effectmenmodifiable behaviormotivational processesneglectpersonalized medicinephysical symptompilot testpost interventionprimary outcomeprotective allelerecruitresponsescale upsecondary outcomesexundergraduate studentuniversity studentweb-based intervention
项目摘要
Abstract
The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase.
Several genes (ALDH2, ADH1B) that encode these enzymes have variant alleles that alter the rate of metabolism
and result in heightened and protracted exposure to acetaldehyde, a known carcinogen. The variant ALDH2*2
allele is associated with the flushing response (i.e., “Asian glow”) and is found almost exclusively in individuals
of east Asian descent (560+ million people worldwide). Although possession of variant ALDH2 and ADH1B
alleles are protective against heavy drinking and alcohol use disorders, for those who do drink, these variants
also are independently and synergistically associated with striking elevations in risk for several cancers, including
esophageal and head and neck cancers. This cancer risk, however, is not widely known outside of the research
community. The premise of this study is that we can affect early drinking trajectories through personalized
communication about these cancer risks. We specifically target 360 college students of northeast Asian descent,
a high-risk group as college is a time of escalating alcohol consumption. It is also a context in which a risk-
communications intervention, if successful, could be readily scaled-up. We will compare risk communication with
and without personalized genotype feedback by randomizing participants into one of three groups: 1) a group
receiving information about cancer risk associated with alcohol consumption and alcohol metabolism genetic
deficiencies that manifest as flushing, plus personalized flushing (i.e. phenotype) feedback (PHEN), 2) a group
receiving the PHEN information plus personalized genotype feedback on ALDH2 and ADH1B (PHEN+GENE),
or 3) a comparison attention CONTROL group receiving duplicate information from the AlcoholEdu® for College
mandatory online training about alcohol risk already completed by all incoming students. In Aim 1, we will develop
the brief web-based interventions. In Aim 2, we will test our hypotheses that a) informing drinkers of risk will
lower alcohol consumption levels and use of “flush cures”, and b) informing non-drinkers will reduce or delay
drinking onset. We also will test if genotype feedback results in a greater attenuation of drinking than general
risk information and phenotype feedback only, and if the impact is stronger in those at greater risk based on their
phenotype and/or genotypes. Finally, we will test the possible mediating roles of perceived cancer risk, cancer
prevention self-efficacy, and alcohol expectancies as underlying mechanisms of behavior change. Aim 3 will
determine study effect sizes within the latent growth modeling framework we will employ, including for our
mediation analyses. These analyses will establish the feasibility of implementing these interventions and setting
the stage for a larger multisite study. Results of this work may inform intervention/prevention efforts on how to
optimally target personalized feedback protocols for high-risk college samples and scale these at a national level.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SUSAN E LUCZAK其他文献
SUSAN E LUCZAK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SUSAN E LUCZAK', 18)}}的其他基金
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor Data
估算透皮酒精中的 BrAC/BAC:将第一原理生理模型与机器学习相结合,创建软件以优化处理和定量解释生物传感器数据
- 批准号:
10402188 - 财政年份:2018
- 资助金额:
$ 15.47万 - 项目类别:
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor Data
估算透皮酒精中的 BrAC/BAC:将第一原理生理模型与机器学习相结合,创建软件以优化处理和定量解释生物传感器数据
- 批准号:
10375443 - 财政年份:2018
- 资助金额:
$ 15.47万 - 项目类别:
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor Data
估算透皮酒精中的 BrAC/BAC:将第一原理生理模型与机器学习相结合,创建软件以优化处理和定量解释生物传感器数据
- 批准号:
9902264 - 财政年份:2018
- 资助金额:
$ 15.47万 - 项目类别:
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor Data
估算透皮酒精中的 BrAC/BAC:将第一原理生理模型与机器学习相结合,创建软件以优化处理和定量解释生物传感器数据
- 批准号:
10529069 - 财政年份:2018
- 资助金额:
$ 15.47万 - 项目类别:
Estimating BrAC/BAC from Transdermal Alcohol: Combining First-Principles Physiological Models with Machine-Learning to Create Software to Optimally Process and Quantitatively Interpret Biosensor Data
估算透皮酒精中的 BrAC/BAC:将第一原理生理模型与机器学习相结合,创建软件以优化处理和定量解释生物传感器数据
- 批准号:
10132950 - 财政年份:2018
- 资助金额:
$ 15.47万 - 项目类别:
Intergenerational Transmission of Alcohol Involvement
酒精参与的代际传播
- 批准号:
8139849 - 财政年份:2010
- 资助金额:
$ 15.47万 - 项目类别:
Intergenerational Transmission of Alcohol Involvement
酒精参与的代际传播
- 批准号:
8316467 - 财政年份:2010
- 资助金额:
$ 15.47万 - 项目类别:
Intergenerational Transmission of Alcohol Involvement
酒精参与的代际传播
- 批准号:
8299391 - 财政年份:2010
- 资助金额:
$ 15.47万 - 项目类别:
Intergenerational Transmission of Alcohol Involvement
酒精参与的代际传播
- 批准号:
8496652 - 财政年份:2010
- 资助金额:
$ 15.47万 - 项目类别:
Intergenerational Transmission of Alcohol Involvement
酒精参与的代际传播
- 批准号:
7988003 - 财政年份:2010
- 资助金额:
$ 15.47万 - 项目类别:
相似海外基金
An enzyme-based assay for the detection of acetaldehyde-protein adducts
用于检测乙醛-蛋白质加合物的酶测定法
- 批准号:
10760201 - 财政年份:2023
- 资助金额:
$ 15.47万 - 项目类别:
Dissecting the role of acetaldehyde in oral carcinogenesis
剖析乙醛在口腔癌发生中的作用
- 批准号:
10345780 - 财政年份:2022
- 资助金额:
$ 15.47万 - 项目类别:
Dissecting the role of acetaldehyde in oral carcinogenesis
剖析乙醛在口腔癌发生中的作用
- 批准号:
10706454 - 财政年份:2022
- 资助金额:
$ 15.47万 - 项目类别:
Identification of mutation patterns induced by acetaldehyde exposure
乙醛暴露引起的突变模式的鉴定
- 批准号:
20K17047 - 财政年份:2020
- 资助金额:
$ 15.47万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RUI: Collaborative: Cycling of ethanol and acetaldehyde in coastal waters
RUI:合作:沿海水域乙醇和乙醛的循环
- 批准号:
2022184 - 财政年份:2020
- 资助金额:
$ 15.47万 - 项目类别:
Standard Grant
Reconsideration of the drinking habit of alcoholic liver disease patients from the viewpoint of acetaldehyde-derived advanced glycation end products
从乙醛衍生晚期糖基化终末产物角度重新思考酒精性肝病患者饮酒习惯
- 批准号:
19K11803 - 财政年份:2019
- 资助金额:
$ 15.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Pathogenic Role of Malondialdehyde-Acetaldehyde Adducts in Rheumatoid Arthritis
丙二醛-乙醛加合物在类风湿性关节炎中的致病作用
- 批准号:
10421254 - 财政年份:2019
- 资助金额:
$ 15.47万 - 项目类别:
Pathogenic Role of Malondialdehyde-Acetaldehyde Adducts in Rheumatoid Arthritis
丙二醛-乙醛加合物在类风湿性关节炎中的致病作用
- 批准号:
10045500 - 财政年份:2019
- 资助金额:
$ 15.47万 - 项目类别:
Pathogenic Role of Malondialdehyde-Acetaldehyde Adducts in Rheumatoid Arthritis
丙二醛-乙醛加合物在类风湿性关节炎中的致病作用
- 批准号:
10516090 - 财政年份:2019
- 资助金额:
$ 15.47万 - 项目类别:
Analysis of the molecular mechanism to repair acetaldehyde-induced DNA damage
修复乙醛所致DNA损伤的分子机制分析
- 批准号:
17K17846 - 财政年份:2017
- 资助金额:
$ 15.47万 - 项目类别:
Grant-in-Aid for Young Scientists (B)














{{item.name}}会员




