Relationship between lipoprotein abnormalities in childhood and the risk for atherosclerotic coronary heart disease in adulthood(Comparison of the effects of genetic and environmental factors on dyslipidemia between children and adults)
儿童期脂蛋白异常与成年后动脉粥样硬化性冠心病风险的关系(遗传因素和环境因素对儿童与成人血脂异常的影响比较)
基本信息
- 批准号:13470166
- 负责人:
- 金额:$ 8.96万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1.Acyl-CoA : cholesterol acyltransferase(ACAT)plays important roles in cellular cholesterol homeostasis.Two isoforms of ACAT have been reported(ACAT-1 and ACAT-2).An ACAT inhibitor was shown to have a lipid-lowering effect.The present study was carried out to clarify the relationship between ACAT-1 gene variants and hyperlipidemia.A missense variant(R526G), and a variant in the 5' untranslated region(-77G-.A) were identified.R526G variant did not affect plasma concentrations of lipids or apolipoproteins in subjects studied. However, among hyperlipidemic subjects, plasma concentrations of HDL-C and apoA-I in subjects with -77G-'A variant were significantly higher than those in subjects without variant.These data suggest that the intracellular PC concentration might modulate plasma HDL concentrations.2.Small LDL particles are more atherogenic than larger LDL particles.To help prevent atherosclerotic coronary heart diseases(ACHD), it may be useful to understand risk factors during childhood. We evaluated LDL-size and its relation tQ other risk factors for ACHD.LDL-size was measured by gradient gel electrophoresis in 586 children.Pattern B(LDL-size < 25.5 nm)was found in 10.8 % of boys and 4.4 % of girls.Children with pattern B had a higher body mass index (BMI) and insulin resistance, and a more atherogenic lipoprotein profile than those with pattern A (LDL-size> 25.5 nm).BMI, insulin resistance and plasma concentrations of TG, glucose and insulin decreased and plasma concentrations of HDL-C and apoA-I increased as LDL-size increased.HDL-C and insulin in boys, and BMI, HDL-C and apoA-I in girls predicted 22.9 % and 28.1 % of the variability of LDL-size, respectively.Although the contribution Qf these parameters to LDL-size in children was less than that in adults, improvement of these parameters by changes in lifestyle might be important for preventing the development of atherosclerosis, even in children.
1.酰基辅酶A:胆固醇酰基转移酶(ACAT)在细胞胆固醇稳态中起重要作用,目前已报道有两种ACAT异构体(ACAT-1和ACAT-2)。ACAT抑制剂被证明具有降脂作用。本研究旨在阐明ACAT-1基因变异与高脂血症之间的关系。一种错义变异(R526 G),R526 G变异体不影响受试者的血脂或载脂蛋白的血浆浓度。而在高脂血症患者中,-77G-'A变异者的血浆HDL-C和apoA-I浓度显著高于无变异者,提示细胞内PC浓度可能调节血浆HDL浓度。2.小LDL颗粒比大LDL颗粒更易致动脉粥样硬化,为了预防动脉粥样硬化性冠心病(ACHD),了解儿童时期的风险因素可能是有益的。我们评估了LDL-大小及其与ACHD其他危险因素的关系,采用梯度凝胶电泳法测定了586名儿童的LDL-大小。在10.8%的男孩和4.4%的女孩中发现了LDL-大小< 25.5 nm。具有模式B的儿童具有较高的体重指数(BMI)和胰岛素抵抗,和比A型更易致动脉粥样硬化的脂蛋白(LDL大小> 25.5nm)、BMI、胰岛素抵抗和TG的血浆浓度,随着LDL-大小的增加,葡萄糖和胰岛素降低,HDL-C和apoA-I的血浆浓度增加。女孩HDL-C和apoA-I分别预测LDL值的22.9%和28.1%,虽然这些参数对儿童LDL值的贡献小于成人,但通过改变生活方式改善这些参数对预防动脉粥样硬化的发展可能是重要的,即使是在儿童中。
项目成果
期刊论文数量(80)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Miura S, et al.: "Transfer of antisense oligodeoxynucleotides against endothelin receptors and B into human coronary smooth muscle cells and endothelial cells by apolipoprotein E peptide."Circulation Journal. 66. 1054-1056 (2002)
Miura S 等人:“通过载脂蛋白 E 肽将针对内皮素受体和 B 的反义寡脱氧核苷酸转移到人冠状平滑肌细胞和内皮细胞中。”循环杂志。
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- 影响因子:0
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- 通讯作者:
Kuromori Y, et al.: "Familial combined hyperlipidemia(FCHL)in children : the significance of early development of hyperapoB lipoproteinemia, obesity and aging."J Atheroscler Thromb. 9. 314-320 (2002)
Kuromori Y 等人:“儿童家族性联合高脂血症 (FCHL):早期发生高 apoB 脂蛋白血症、肥胖和衰老的意义。”J 动脉粥样硬化血栓。
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- 影响因子:0
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Arashiro R: "Effect of Trp64Arg Mutation of the β3-Adrenergic Receptor Gene arid C161T Substitution of the Peroxisome Proliferator Activated Receptor g Gene on Obesity in Japanese Children"Pediatr Int. (In press). (2003)
Arashiro R:“β3-肾上腺素受体基因的 Trp64Arg 突变和过氧化物酶体增殖物激活受体 g 基因的 C161T 取代对日本儿童肥胖的影响”Pediatr Int。
- DOI:
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- 影响因子:0
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Katsuren K.: "Structure of the human acyl-CoA : cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia"Biochimica et Biophysica Acta. 66. 230-240 (2001)
Katsuren K.:“人酰基辅酶A的结构:胆固醇酰基转移酶-2(ACAT-2)基因及其与血脂异常的关系”Biochimica et Biophysicala Acta。
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- 影响因子:0
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Katsuren K: "Effects of a New Single-Nucleotide Polymorphism in the Acyl-CoA : Cholesterol Acyltransferase-2 Gene on Plasma Lipids and Apolipoproteins in Patients with Hyperlipidemia."J Antheroscler Thromb. 44. 32-36 (2003)
Katsuren K:“酰基辅酶 A 中新的单核苷酸多态性:胆固醇酰基转移酶 2 基因对高脂血症患者血浆脂质和载脂蛋白的影响。”J Antheroscler Thromb。
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- 影响因子:0
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OHTA Takao其他文献
OHTA Takao的其他文献
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{{ truncateString('OHTA Takao', 18)}}的其他基金
Nonlinear dynamics of self-propelled systems
自推进系统的非线性动力学
- 批准号:
23540449 - 财政年份:2011
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Relationship between lifestyle-related diseases in childhood and the risk for atherosclerotic coronary heart disease in adulthood (studies on lipoprotein abnormality, adipocytokine, vascular endothelial function and related genes)
儿童期生活方式相关疾病与成年后动脉粥样硬化性冠心病风险的关系(脂蛋白异常、脂肪细胞因子、血管内皮功能及相关基因研究)
- 批准号:
17390303 - 财政年份:2005
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Kinetics of structural transitions in polymeric systems ・・・properties of gyroid structure・・・
聚合物体系中结构转变的动力学・・・螺旋结构的性质・・・
- 批准号:
16340123 - 财政年份:2004
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Dynamical entropy control and macroscopic phase separation in strongly correlated soft materials
强关联软材料中的动态熵控制和宏观相分离
- 批准号:
13031062 - 财政年份:2001
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Applied mathematics of pattern formation in material sciences
材料科学中模式形成的应用数学
- 批准号:
13554001 - 财政年份:2001
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Correlation of Lipoprotein Abnormalities in Childhood with the Risk for Atherosclerotic Coronary Heart Disease (CAD) in Adulthood (HDL function and polymorphism in HDL related genes)
儿童期脂蛋白异常与成年期动脉粥样硬化性冠心病 (CAD) 风险的相关性(HDL 功能和 HDL 相关基因多态性)
- 批准号:
09670817 - 财政年份:1997
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Robust balses in reaction-diffusion system
反应扩散系统中的稳健平衡
- 批准号:
08640480 - 财政年份:1996
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Self-Organized Pulse Generator in a Reaction-Diffusion System
反应扩散系统中的自组织脉冲发生器
- 批准号:
06835007 - 财政年份:1994
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Correlation of Lipoprotein Abnormalities in Childhood withe the Risk for Atherosclerotic Coronary Heart Disease (CAD) in Adulthood (Is abnormaltites in childhood a risk factor for CAD? )
儿童期脂蛋白异常与成年期动脉粥样硬化性冠心病 (CAD) 风险的相关性(儿童期异常是 CAD 的危险因素吗?)
- 批准号:
06670809 - 财政年份:1994
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Pattern Dynamics in an Excitable Reaction Diffusion System
可兴奋反应扩散系统中的模式动力学
- 批准号:
04640363 - 财政年份:1992
- 资助金额:
$ 8.96万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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