Genetic study on interaction among carcinogenesis, proliferation and progression in oral epithelia and mesenchymal tissues

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I.The expression of cancer related genes (p53,mdm2,p14) in oral squamous cell carcinomas and leukoplakia were examined immunohistochemically.1.The expression rate of p53 was 23.2%, that of mdm2 was 44.6%, and that of p14 was 56.0% in leukoplakia. Only p14 expression was correlated with cellular atypism, and as atypism was severe, the rate of expression was reduced. The expression rate of p53 was 40.8%, that of mdm2 was 46.9% and that of p14 was 22.9% in oral squamous cell carcinomas, and as differentiation was poor, the expression rate was reduced.2.The expression rate of mdm2(+)/p14(+) was 85% in normal gingiva, 37% in leukoplakia (carcinogenesis), 30% in leukoplakia(no carcinogenesis), and 19% in squamous cell carcinomas. As atypical cells increased, the simultaneous expression rate of mdm2 and p14 was reduced. In squamous cell carcinoma, as differentiation was poor, the simultaneous expression rate of mdm2 and p14 was reduced.3.The only mdm2 expression rate was 0% in normal gingiva, 12% in leukoplakia (carcinogenesis) and 27.8% in oral squamous cell carcinomas. The expression of mdm2 was correlated with malignancy.4.The expression rate of mdm2 in stroma was 25.8% (non carcinogenesis) and 48.0% (carcinogenesis) in leukoplakia. According to the TNM classification, the mdm2 expression rate of early tumor stage cases was higher than that of advanced tumor stage cases.The expression rate of mdm2 of stroma was 7.7% in normal gingiva and 85% in oral lichen planus.