Establishment of human tumor xenotransplantation models as a pre-clinical assisting tool for translational research

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In the recent strategy for treatment of cancer disease, concepts such as the order-made treatment and the target-oriented therapy are arising in consideration. To translate the basic research results based on these concepts, pre-clinical in vivo models to evaluate such treatment strategies are very important. We have been establishing human tumor xenografts, and we maintain over 600 lines of various organ tumors from human origin. In this study, we analyzed gene expression profiles and chemosensitivities of those human tumor xenografts. We used cDNA microarray representing 23,040 genes to analyze expression profiles in a panel of 85 tumor xenografts derived from human breast, lung, stomach, colon, pancreas, and other four organs. We also examine chemosensitivities for these tumors on 9 antitumor drugs including CDDP, mitomycin C,5-FU. Comparison of the gene expression profiles and chemosensitivities of the tumors identified that 1,578 genes whose expression levels correlated significantly with drug effectiveness; 333 of those genes showed significant correlation with two or more drugs. These data should contribute useful information for identifying predictive markers for drug sensitivity that may eventually provide personalized chemotherapy for individual patients.