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The development of novel biomedical material having high intensity and water repellence : the synthesis and analysis of the block copolymer having fluoroethylene and aramid segment

高强度拒水新型生物医用材料的开发：含氟乙烯和芳纶链段嵌段共聚物的合成与分析

基本信息

批准号：
13480300
负责人：
FURUZONO Tsutomu
金额：
$ 9.66万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

In the medical field, it is well known that polytetrafluoroethylene (PTFE) is applied to artificial vessels due to their low bioactivity. However, one of the clinical problems caused by PTFE is ischemia by twist in living body. We selected the aromatic polyamides (aramids) as another functional material to overcome the problem of the mechanical properties of PTFE. The target of this study is the development of novel artificial vessels by synthesizing the block copolymer containing fluoroethylene and aramid segments.1)The synthesis of the block copolymers containing fluoroethylene and aramid segmentsFirst, a block copolymer was synthesized by low-temperature solution polycondensation of telechelic diamine containing fluoroethylene segments and isophthaloyl chloride [JP Patent 2002-252183 (2002), J.Polym.Sci., Part A : Polym. Chem., 41, 2840 (2003)]. Secondary block copolymers containing chain-controlled aramid and fluoroethylene number-average molecular weight of these copolymers were 1.7×10^4 and 2.0×10^4, respectively. We attempted the preparation of cast films from these copolymers. These films had uniform thickness, but do not have good mechanical properties.2)The analyses of the surface and physical propertiesWe planned the analysis of the surface and physical properties of these copolymers. But we could not evaluate these properties because too much time was taken to synthesize these copolymers and prepare films. It is assumed that it is possible to synthesize the block copolymer having good mechanical properties by distribution adjustment of fluoroethylene and aramid segments. By overcome the problem of mechanical properties, it is expected that these copolymers are applied artificial vessels.

在医学领域，众所周知，聚四氟乙烯（PTFE）由于其低生物活性而应用于人造血管。然而，PTFE引起的临床问题之一是在活体内扭转引起的缺血。我们选择芳香族聚酰胺（aramids）作为另一种功能材料，以克服PTFE的机械性能问题。本研究的目标是通过合成含氟乙烯和芳族聚酰胺链段的嵌段共聚物来开发新型人工血管。1）含氟乙烯和芳族聚酰胺链段的嵌段共聚物的合成首先，通过含氟乙烯链段的遥爪二胺和间苯二甲酰氯的低温溶液缩聚来合成嵌段共聚物[JP专利2002-252183（2002），J. Polym.Sci.，A部分：聚合物化学成分：41，2840（2003）]。含链控芳族聚酰胺和氟乙烯的二级嵌段共聚物的数均分子量分别为1.7×10^4和2.0×10^4。我们尝试从这些共聚物制备流延膜。这些薄膜厚度均匀，但力学性能不好。2）表面和物理性能分析我们计划对这些共聚物的表面和物理性能进行分析。但是我们不能评估这些性能，因为合成这些共聚物和制备薄膜花费了太多的时间。据推测，有可能通过氟乙烯和芳族聚酰胺链段的分布调整来合成具有良好机械性能的嵌段共聚物。通过克服力学性能的问题，有望将这些共聚物应用于人工血管。