Clinical research of living related pancreas transplantation

活体胰腺移植的临床研究

• 批准号: 13557106
• 负责人: KURODA Yoshikazu
• 金额: $ 7.04万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557106/
• 关键词: pancreas transplantation; live donor pancreas transplantation; pancreatico-enteric anastomosis; pancreatic fistula; pancreatic leak; 膵島移植; 生体膵島移植; 拒絶反応

Prevention of pancreatic fistula is important to improve the outcomes after live donor pancreas transplantation both for recipients and donors. During this research period, we established safety of pancreatic resection using an ultrasonic dissector and our novel pancreaticojejunostomy, that is, pancreatic duct invagination anastomosis in a series of pancreatic surgery (World J Surgery 26(2), 63-69, 2002, Arch Surg 137, 1044-1047, 2002, Hepato-Gastroenterol 49(46), 1124-1129,2002).We also developed an objective and rapid pretransplant assessment technique for pancreas graft viability using ^<31>P-Nuclear Magnetic Resonance spectroscopy combined with two-layer cold storage method (TLM) (Transplantation 78(1), 78-82, 2004). TLM that we had previously developed is a pancreas preservation modality supplying sufficient oxygen to the grafts during preservation. This assessment technique is available for future pancreas transplantation at our institution.In addition, we experimentally established a surgical technique of retroperitoneoscopic laparoscopic distal pancreatectomy with spleen salvage (Hlepato-Gastroenterol 51(58), 9 25-927, 2004)So far, we have registered 6 patients with type 1 diabetes to the Organ Transplant Network for cadaver pancreas transplant. While these patients wait for pancreas donation from brain-dead donors, they receive the appropriate treatment by the diabetologists at our center in recent years. Because live donor pancreas transplantation has been approved by the hospital committee, we informed all these patients on this option. The living donor pancreas transplant is under consideration for one of these patients.

预防胰瘘对改善活体胰腺移植术后供、受者的预后具有重要意义。在此研究期间，我们在一系列胰腺手术中，建立了使用超声剥离器和我们的新型胰管空肠吻合术（即胰管套叠吻合术）进行胰腺切除的安全性（World J Surgery 26（2），63-69，2002，Arch Surg 137，1044-1047，2002，Hepato-Gastroenterol 49（46），1124- 1129，2002）。我们还开发了一种使用13 P-核磁共振光谱结合双层冷藏方法（TLM）的胰腺移植物存活力的客观和快速移植前评估技术<31>（Transplantation 78（1），78-82，2004）。我们以前开发的TLM是一种胰腺保存方式，在保存过程中为移植物提供足够的氧气。此外，我们实验性地建立了一种后腹腔镜腹腔镜胰尾切除术联合保脾的手术技术（Hlepato-Gastroenterol 51（58），9 25-927，2004）。到目前为止，我们已经在器官移植网络中登记了6例1型糖尿病患者进行尸体胰腺移植。近年来，这些患者在等待脑死亡捐赠者捐赠胰腺的同时，接受了本中心糖尿病专家的适当治疗。因为活体胰腺移植已经得到了医院委员会的批准，我们通知了所有这些患者这一选择。其中一名患者正在考虑进行活体胰腺移植。

项目成果

Suzuki Y, Fujino Y, Ku Y, Tanioka Y, Ajiki T, Kuroda Y, et al.: "A new pancreatic duct-invagination anastomosis using ultrasonic dissection for non-fibrotic pancreas with a nondilated duct"World Journal of Surgery. 26・2. 162-165 (2002)

Suzuki Y、Fujino Y、Ku Y、Tanioka Y、Ajiki T、Kuroda Y 等人：“一种使用超声解剖的新型胰管内陷吻合术，用于具有非扩张管的非纤维化胰腺”《世界外科杂志》26。 2. 162-165（2002）

Suzuki Y: "Selection of pancreaticojejunostomy techniques according to pancreatic texture and duct size"Archives of Surgery. (In press).

铃木 Y：“根据胰腺质地和导管大小选择胰空肠造口术技术”外科档案。

Takada M, Suzuki Y, Kuroda Y: "Retroperitoneoscopic laparoscopic distal pancreatectomy with spleen salvage"Hepato-Gastroenterol. (in press).

Takada M、Suzuki Y、Kuroda Y：“后腹腔镜腹腔镜远端胰腺切除术及脾脏挽救”肝胃肠病学。

Suzuki Y, Fujino Y, Tanioka Y, Hiraoka K, Kuroda Y, et al.: "Selection of pancreaticojejunostomy techniques according to pancreatic texture and duct size"Archives of Surgery. 137. 1044-1047 (2002)

Suzuki Y、Fujino Y、Tanioka Y、Hiraoka K、Kuroda Y 等人：“根据胰腺质地和导管大小选择胰肠空肠吻合术技术”外科档案。

Fujino Y: "Possible role of heat shock protein 60 reducing ischemia-reperfusion injury in canine pancreas grafts after preservation by the two-layer method"Pancreas. 23・4. 393-398 (2001)

Fujino Y：“热休克蛋白60在通过两层法保存后减少犬胰腺移植物缺血再灌注损伤的可能作用”23・4（2001）。