Clinical research of living related pancreas transplantation

预防胰瘘对于改善活体胰腺移植后的受者和供者的预后都很重要。在本研究期间，我们建立了使用超声解剖术和我们的新型胰空肠吻合术，即胰管内陷吻合在一系列胰腺手术中的安全性(World J surgery 26（2), 63- 69,2002, Arch Surg 137, 1044- 1047,2002, Hepato-Gastroenterol 49(46), 1124-1129,2002）。我们还开发了一种客观快速的移植前评估技术，使用^<31> p -核磁共振波谱结合双层冷藏法（TLM） （Transplantation 78(1), 78- 82,2004）。我们之前开发的TLM是一种胰腺保存方式，在保存期间为移植物提供足够的氧气。该评估技术可用于我们机构未来的胰腺移植。此外，我们实验性地建立了后腹腔镜下远端胰腺切除术保脾的手术技术（helpato - gastroenterol 51(58), 9 25- 927,2004）。到目前为止，我们已经登记了6例1型糖尿病患者到器官移植网络进行尸体胰腺移植。当这些患者等待脑死亡捐赠者的胰腺捐赠时，他们近年来接受了我们中心糖尿病专家的适当治疗。因为活体供体胰腺移植已经得到了医院委员会的批准，我们告知了所有这些患者这个选择。其中一名患者正在考虑活体胰腺移植。

Prevention of pancreatic fistula is important to improve the outcomes after live donor pancreas transplantation both for recipients and donors. During this research period, we established safety of pancreatic resection using an ultrasonic dissector and our novel pancreaticojejunostomy, that is, pancreatic duct invagination anastomosis in a series of pancreatic surgery (World J Surgery 26(2), 63-69, 2002, Arch Surg 137, 1044-1047, 2002, Hepato-Gastroenterol 49(46), 1124-1129,2002).We also developed an objective and rapid pretransplant assessment technique for pancreas graft viability using ^<31>P-Nuclear Magnetic Resonance spectroscopy combined with two-layer cold storage method (TLM) (Transplantation 78(1), 78-82, 2004). TLM that we had previously developed is a pancreas preservation modality supplying sufficient oxygen to the grafts during preservation. This assessment technique is available for future pancreas transplantation at our institution.In addition, we experimentally established a surgical technique of retroperitoneoscopic laparoscopic distal pancreatectomy with spleen salvage (Hlepato-Gastroenterol 51(58), 9 25-927, 2004)So far, we have registered 6 patients with type 1 diabetes to the Organ Transplant Network for cadaver pancreas transplant. While these patients wait for pancreas donation from brain-dead donors, they receive the appropriate treatment by the diabetologists at our center in recent years. Because live donor pancreas transplantation has been approved by the hospital committee, we informed all these patients on this option. The living donor pancreas transplant is under consideration for one of these patients.