Clinical research of living related pancreas transplantation

无论对受体还是供者来说，预防胰瘘对于改善活体胰腺移植后的预后都是重要的。在这一研究期间，我们在一系列的胰腺手术(World J Surgery 26(2)，63-69,2002，Arch Surg 137,1044-1047,2002，Hepato-Gastenterol 49(46)，1124-1129,2002)中建立了使用超声解剖器和我们的新的胰腺空肠吻合术，即胰管内陷吻合术的安全性。我们还开发了一种客观和快速的移植前评估胰腺移植物存活的技术，使用^&lt；31&gt；P-核磁共振波谱结合双层冷冻法(TLM)(移植78(1)，78-82,2004)。我们以前开发的TLM是一种胰腺保存方式，在保存过程中为移植物提供足够的氧气。此外，我们实验性地建立了后腹腔镜下保留脾的胰腺远端切除的外科技术(Hlepato-Gasterenterol 51(58)，9 25-927,2004)，到目前为止，我们已经向器官移植网络登记了6名1型糖尿病患者进行身体胰腺移植。这些患者在等待脑死亡供者的胰腺捐赠的同时，近年来在我们中心接受了糖尿病专家的适当治疗。由于活体供体胰腺移植已经得到医院委员会的批准，我们通知了所有这些患者这一选择。其中一名患者正在考虑进行活体胰腺移植。

Prevention of pancreatic fistula is important to improve the outcomes after live donor pancreas transplantation both for recipients and donors. During this research period, we established safety of pancreatic resection using an ultrasonic dissector and our novel pancreaticojejunostomy, that is, pancreatic duct invagination anastomosis in a series of pancreatic surgery (World J Surgery 26(2), 63-69, 2002, Arch Surg 137, 1044-1047, 2002, Hepato-Gastroenterol 49(46), 1124-1129,2002).We also developed an objective and rapid pretransplant assessment technique for pancreas graft viability using ^<31>P-Nuclear Magnetic Resonance spectroscopy combined with two-layer cold storage method (TLM) (Transplantation 78(1), 78-82, 2004). TLM that we had previously developed is a pancreas preservation modality supplying sufficient oxygen to the grafts during preservation. This assessment technique is available for future pancreas transplantation at our institution.In addition, we experimentally established a surgical technique of retroperitoneoscopic laparoscopic distal pancreatectomy with spleen salvage (Hlepato-Gastroenterol 51(58), 9 25-927, 2004)So far, we have registered 6 patients with type 1 diabetes to the Organ Transplant Network for cadaver pancreas transplant. While these patients wait for pancreas donation from brain-dead donors, they receive the appropriate treatment by the diabetologists at our center in recent years. Because live donor pancreas transplantation has been approved by the hospital committee, we informed all these patients on this option. The living donor pancreas transplant is under consideration for one of these patients.