Development of non invasive lower urinary tract function test using ultrasound Doppler imaging

超声多普勒成像无创下尿路功能测试的发展

• 批准号: 13557135
• 负责人: KUMON Hiromi
• 金额: $ 5.57万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557135/
• 关键词: voiding disorder; urodynamic study; bladder outlet obstruction; benign prostatic hyperplasia; Doppler ultrasonography

1. Flow velocity of urine can be measured by ultrasound sonographyIt had been believed to be impossible to measure the intraurethral flow velocity by ultrasonography, since urine does not contain any particles reflecting ultrasound. We hypothesized that according to Bernoulli's principle a decrease of flow pressure caused by an accelerated urinary flow produces micro bubbles associated with cavitation responsible for Doppler signals. This hypothesis was confirmed by A simultaneous detection of microtubbles specific to cavitation with a charged-coupled device (CCD) camera and Doppler signals with an ultrasound scanner was conducted.2. Velocity related parameters are proved to be useful for evaluating bladder outlet obstruction(BOO).Functional cross-sectional area at prostatic urethra (UFA=UR/UV: UV: velocity at prostatic urethra, UR: flow rate) and velocity ratio (VR=V1/V2: V1: velocity at prostatic urethra, V2: velocity at sphincteric urethra) were proved to be practical parameters far evaluating BOO. "'e investigated the best flow velocity related parameter, which allowed prediction of improvement of lower urinary tract symptoms (LUTS) after α 1-blocker treatment.. The patients with higher V2 might be poor responders against alpha-blocker treatment.3. Custom made software has been improved.In order to reduce analytic time and apply the system not only for BOO but also for whole voiding dysfunction, analytic software has been improved.(1) Automatic plotting of ROI (region of interest) ~(2) Indication of corrected angle(3) Automatic graphic indication of previously proposed parameters (Al, A2 and VR)(4) Automatic graphic indication of new parameters to analyze bladder function4. Velocity-flow plots.Two dimensional graph plots between velocity related parameter and flow rate in whole voiding has been performed. A delay of initial velocity signal may be useful to diagnose voiding dysfunction

1.尿的流速可以通过超声检查来测量，由于尿中不含任何反射超声的颗粒，因此人们一直认为用超声检查来测量尿道内的流速是不可能的。我们假设，根据伯努利原理，由加速的尿流引起的流动压力的降低产生与负责多普勒信号的空化相关的微气泡。这一假设得到了证实，同时检测微管特定的空化与电荷耦合器件（CCD）相机和多普勒信号与超声扫描仪进行.前列腺尿道功能截面积（乌法=UR/UV：UV：前列腺尿道流速，UR：流速）和流速比（VR=V1/V2：V1：前列腺尿道流速，V2：括约肌尿道流速）是评价膀胱出口梗阻（BOO）的实用参数。“我们研究了最佳流速相关参数，该参数可预测α 1受体阻滞剂治疗后下尿路症状（LUTS）的改善。V2较高的患者可能对α-受体阻滞剂治疗反应较差.为了缩短分析时间，使系统不仅适用于BOO，而且适用于整个排尿功能障碍，对分析软件进行了改进。(1)自动绘制ROI（感兴趣区域）~（2）指示校正角度（3）自动图形指示先前建议的参数（A1、A2和VR）（4）自动图形指示新参数以分析膀胱功能4.速度-流量图：绘制了速度相关参数与整个空穴流量之间的二维图。初速度信号的延迟可能有助于诊断排尿功能障碍

项目成果

西垣 和: "超音波カラードップラー法によるキャビテーションの検出と流速測定"神戸商船大学紀要. 49. 57-63 (2001)

Kazu Nishigaki：“超声波彩色多普勒法的空化检测和流速测量”神户商业海洋大学通报49. 57-63（2001）。

西口 潤, 小澤秀夫, 西垣 和, 公文裕巳 他: "超音波カラードプラ法によるモデル尿道内でのキャビテーションの検出と流速測定"日本泌尿器科学会雑誌. 93(2). 354 (2002)

Jun Nishiguchi、Hideo Ozawa、Kazu Nishigaki、Hiromi Kumon 等：“使用超声彩色多普勒方法检测模型尿道中的空化和流速”，日本泌尿外科协会杂志 93(2) 354 (2002)。

Kusaka Nobuyuki: "Transrectal ultrasound for monitoring murine orthotopic prostate tumor"Prostate. 47(2). 118-124 (2001)

Kusaka Nobuyuki：“经直肠超声监测小鼠原位前列腺肿瘤”前列腺。

Jun Nishiguchi: "Detection of cavitation and measurement of flow velocity in an experimental urethra by means of color Doppler system"Japan Urological. Aasociatioa 93(2). 354 (2002)

Jun Nishiguchi：“通过彩色多普勒系统检测实验尿道中的空化并测量流速”日本泌尿外科。

小澤秀夫, 横山光彦, 公文裕巳 他: "前立腺肥大症に対するα遮断薬投与によるIPSS改善度の予測-経会陰超音波ドプラ法の有用性-"日本泌尿器科学会雑誌. 93(2). 164 (2002)

Hideo Ozawa、Mitsuhiko Yokoyama、Hiromi Kumon 等人：“由于使用 α 阻滞剂治疗良性前列腺增生，IPSS 改善的预测 - 经会阴多普勒超声的用途”，日本泌尿外科协会杂志 93(2)。