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Modeling of human neuromuscular system in due consideration of nonlinearities in muscle contraction process

适当考虑肌肉收缩过程非线性的人体神经肌肉系统建模

基本信息

批准号：
15500336
负责人：
SAITO Masami
金额：
$ 1.98万
依托单位：
Suzuka National College of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500336/
关键词：
vertebrates neuromuscular system muscle contraction process modeling human biceps brachii isotonic shortening slow release EMG signal 筋収縮力発生モデル筋小胞体モデル筋電位シミュレーション slow release試験非線形特性

项目摘要

Modeling of the motion control system (neuromuscular system) of vertebrates is studied to understand the kinetic behavior of their musculoskeletal systems and/or to apply the model to medical and engineering uses. The motor model of the skeletal muscle proposed in this study is a rheological model that works in corporation with the cross-bridge cycling system. The motor model consists of two Maxwell- and one Voigt elements connected in parallel with each other. Weight functions are used to change the visco-elastic constants of the motor in proportion to the force generated. The numerical simulations of the isotonic shortening and the slow stretch/release experiments of the motor are carried out and the energy liberation is calculated. The force-velocity relation of the motor shows a hyperbolic curve and the energy saving function is possessed as in the muscle fibers. The stretch-induced force enhancement and shortening-induced force depression of skeletal muscle are well represented wi … More th an assumption that the force generation ability is increased/decreased corresponding to the amount of the mechanical impulse that the motor is suffered during the slow stretch/release. Then we propose a muscle contraction process model with the function of the Ca^<++> release from the sarcoplasmic reticulum in addition to the aforementioned shortening characteristics of the motor model. The function of the Ca^<++> release is represented by a convolutional integral of the impulse response. The input into the process model is the action potential and the output is the force. The numerical simulations are first carried out with the input of a row of single sinusoidal pulses (corresponding to action potentials) and the time course of force is calculated. The typical force generation behavior of the skeletal muscle, twitch and tetanus, take place according to the frequency of the input signal as observed in muscle fibers, respectively. Finally the measurements of the electromyogram (EMG) signals are made in the force generation experiments of human biceps brachii muscle with five kinds of force generation patterns. The EMG signal data are input into the muscle contraction process model and the time course of force is simulated. The simulation results for all of the force generation patterns coincide well with the experimental results obtained in the force generation experiments. It is confirmed that the model proposed here is quite useful for analyzing and understanding the dynamic behavior of human masculoskeletal systems. Less

脊椎动物运动控制系统（神经肌肉系统）的建模研究，以了解其肌肉骨骼系统的动力学行为和/或应用模型的医疗和工程用途。在这项研究中提出的骨骼肌运动模型是一个流变学模型，与跨桥循环系统。电机模型由两个麦克斯韦和一个福格特元件相互并联连接。权函数用于改变与所产生的力成比例的马达的粘弹性常数。对马达的等张收缩和缓慢拉伸/释放实验进行了数值模拟，并计算了能量释放。电机的力-速度关系呈双曲线，具有与肌纤维相同的节能功能。骨骼肌的牵张力增强和缩短张力降低现象可以通过实验得到很好的描述。 ...更多信息因此，假设力产生能力对应于马达在缓慢拉伸/释放期间所经受的机械脉冲的量而增加/减小。然后，我们提出了一个肌肉收缩过程模型，除了上述运动模型的缩短特性外，还具有肌浆网Ca^<++>释放的功能。Ca^<++>释放的函数由脉冲响应的卷积积分表示。过程模型的输入是动作电位，输出是力。首先进行数值模拟，输入一行单正弦脉冲（对应于动作电位），并计算力的时间过程。骨骼肌的典型力产生行为，抽搐和强直，分别根据在肌纤维中观察到的输入信号的频率发生。最后，在五种不同的发力模式下，对人体肱二头肌的肌电信号进行了测试。将肌电信号数据输入肌肉收缩过程模型，模拟力的时间过程。所有的力产生模式的模拟结果与力产生实验中获得的实验结果吻合良好。它被证实，这里提出的模型是非常有用的分析和理解人类肌肉骨骼系统的动力学行为。少