NEW METHOD OF EVALUATING MUSCLE FUNCTION WITH MAGNETIC RESONANCE IMAGER

使用磁共振成像仪评估肌肉功能的新方法

• 批准号: 15500365
• 负责人: HATAKENAKA Masamitsu
• 金额: $ 2.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500365/
• 关键词: steroid; myopathy; MR; relaxation time; diffusion; MRI; ADC

Purpose :To determine whether muscle fiber atrophy associated with steroid myopathy can be detected with T2 relaxation time.Materials and Methods:Animal and human studies were approved by the ethics committee. Informed consent was obtained. Twelve rabbits were divided into a group that received 3 mg/kg of triamcinolone subcutaneously each day for 10 consecutive days (n_6) and a control group that received saline (n_6). Magnetic resonance (MR) imaging was performed before and after treatment. T2 and fat deposition ratio (FDR) of soleus and gastrocnemius muscles before and after treatment and between control rabbits and rabbits treated with steroids were compared by using two-way repeated analysis of variance and Bonferroni post hoc test to evaluate effects of steroid treatment. After imaging, rabbits were sacrificed. Extracellular space ratio (ECSR) and fiber diameter were examined. Correlation among T2, ECSR, and diameter of type 2 muscle fibers was analyzed with a Pearson correlation … More test with Bonferroni correction in gastrocnemius to determine factors affecting T2. In humans, T2 relaxation time and FDR of both muscles were compared between volunteers not treated with steroids and patients treated with steroids by using an unpaired t test to evaluate the effects of steroids.Results :In rabbits, T2 of gastrocnemius muscle was significantly (P_.01) longer after steroid treatment than before steroid treatment and was also significantly (P_.01) longer than after saline administration. T2 of the gastrocnemius showed no significant difference in control rabbits before or after saline administration or in control rabbits and rabbits before steroid administration. T2 of the soleus muscle or FDR of either muscle showed no significant difference. There was a significant correlation (P_.01) among T2, ECSR, and diameter of type 2 muscle fibers in the gastrocnemius. In humans, T2 of the gastrocnemius was significantly (P_.01) longer in patients than in volunteers. T2 of the soleus or FDR of eithermuscle showed no significant difference.Conclusion :Muscle fiber atrophy associated with steroid myopathy is detectable as prolongation of T2 relaxation time in the gastrocnemius muscle ; the authors believe prolongation of T2 relaxation time is mainly due to increased ECSR reflecting type 2 muscle fiber atrophy. Less

目的：以确定是否与类固醇肌病相关的肌纤维萎缩可以检测T2弛豫time.Materials和方法：动物和人体研究的伦理委员会批准。获得知情同意。12只家兔随机分为两组，一组给予曲安奈德3 mg/kg皮下注射，每日1次，连续10天（n_6），另一组给予生理盐水。治疗前后均行磁共振（MR）检查。采用双向重复方差分析和Bonferroni事后检验比较激素治疗前后及对照组和激素治疗组家兔比目鱼肌和腓肠肌的T2和脂肪沉积率（FDR），以评价激素治疗的效果。成像后，处死家兔。测定细胞外间隙比（ECSR）和纤维直径。T2、ECSR和2型肌纤维直径之间的相关性用Pearson相关分析 ...更多信息 测试腓肠肌Bonferroni校正，以确定影响T2的因素。在人类中，T2松弛时间和FDR的两块肌肉进行了比较志愿者之间没有用类固醇和类固醇治疗的患者通过使用非配对t检验，以评估类固醇的效果。结果：在兔子，腓肠肌T2类固醇治疗后显着（P_0.01）比类固醇治疗前，也显着（P_0.01）比生理盐水给药后更长。对照组家兔在生理盐水给药前后或激素给药前与对照组家兔腓肠肌T2均无显著性差异。比目鱼肌的T2或任一肌肉的FDR没有显示显著差异。T2、ECSR和腓肠肌2型肌纤维直径之间存在显著相关性（P_0.01）。在人体中，患者腓肠肌的T2显著（P_0.01）长于志愿者。结论：类固醇肌病伴肌纤维萎缩表现为腓肠肌T2弛豫时间延长，作者认为T2弛豫时间延长主要是由于反映2型肌纤维萎缩的ECSR增加所致。少

项目成果

Steroid Myopathy : Evaluation of Fiber Atrophy with T2 Relaxation Time-Rabbit and Human Study

类固醇肌病：用 T2 弛豫时间评估纤维萎缩-兔和人体研究

• 发表时间: 2006
• 期刊: Radiology 238
• 作者: Hatakenaka M et al.