A novel framework for nanomedicine development

纳米医学开发的新框架

基本信息

批准号：
10715013
负责人：
Stefan Wilhelm
金额：
$ 37.33万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-07-31
项目状态：
未结题

项目摘要

Project Summary Nanomedicine is a research field centered around applying materials in the nanoscale size range (i.e. nanoparticles) as therapeutics and diagnostics. However, a major challenge is the safe, efficient, and effective delivery of nanoparticles to biological systems, such as cells, tissues, and organs. In this project, we will introduce and explore a novel framework for nanomedicine development with the ultimate goal of efficiently delivering non- viral nanoparticles to cells and tissues for safe and effective applications. Our proposed research program has three main strands: (i) we will develop novel nanoparticles for the safe, efficient, and effective delivery of small molecules and nucleic acid payloads to skeletal muscle cells; (ii) we will develop novel methods for super- resolution bioimaging to study the mechanisms and kinetics of nanoparticle spatiotemporal transport in biological systems; (iii) we will quantify safety, efficiency, and effectiveness of nanoparticle in vivo delivery. Using this novel framework, our long-term scientific goal is to create a major breakthrough in nanomedicine by developing safer, more efficient, and more effective nanoparticles for the non-viral delivery of small molecule-based drugs and nucleic acid payloads to enable therapeutic applications in skeletal muscle disorders.

项目摘要纳米医学是围绕在纳米尺寸范围内应用材料（即纳米颗粒）作为治疗和诊断。但是，一个主要的挑战是安全，高效且有效的将纳米颗粒传递到生物系统，例如细胞，组织和器官。在这个项目中，我们将介绍并探索纳米医学发育的新型框架，其最终目标是有效地提供非 - 病毒纳米颗粒至细胞和组织，以进行安全有效的应用。我们提出的研究计划已有三个主要链：（i）我们将开发新颖的纳米颗粒，以实现安全，高效且有效地交付。分子和核酸有效载荷对骨骼肌细胞；（ii）我们将开发新的超级方法研究生物模仿的生物成像，以研究生物学中纳米颗粒时空转运的机制和动力学系统；（iii）我们将量化纳米颗粒在体内递送中的安全性，效率和有效性。使用这本小说框架，我们的长期科学目标是通过开发更安全的纳米医学营造重大突破用于非病毒基于小分子的药物的非病毒递送的效率更高，更有效的纳米颗粒核酸有效载荷能够在骨骼肌疾病中进行治疗应用。