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Study of dynamic changes in urinary bicarbonate and NOx during local and systemic exercise and significance of these factors as fatigue indices after exercise

局部和全身运动过程中尿碳酸氢盐和氮氧化物的动态变化及其作为运动后疲劳指标的意义研究

基本信息

批准号：
15500458
负责人：
TOMODA Akio
金额：
$ 2.11万
依托单位：
Tokyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

We investigated the changes in various physiological factors, blood lactate, urinary NOx, urinary bicarbonate and urinary pH during quantitative and heavy exercise (local and systemic repetition exercises) and after the termination of the exercise, in healthy male adults. Furthermore, we studied the effects of cooling-down exercise on changes in these physiological parameters after the termination of heavy exercises. Based on these results, dynamics of blood NO and bicarbonate, changes in blood and erythrocytic pH were deduced, and physiological significance and the significance in exercise medicine of these parameters were inspected.As a result, it was found that urinary bicarbonate increased within 3 hours after the termination of exercises, accompanying with the increment of urinary pH. These results were explained by the facts that blood lactate accumulated during heavy exercises was metabolized to carbon dioxide, which was further metabolized to bicarbonate in the blood. Bicarbonate was finally excreted into the urine. As these reactions proceed, a large amount of hydrogen ion was left in the erythrocytes causing decreased oxygen affinity of hemoglobin, and finally inducing systemic cyanosis. These processes could be considered to be associated with fatigue after heavy exercise. When cooling-down exercise was introduced, no increase of urinary bicarbonate was observed, suggesting that the internal circumstances in the body would be improved by cooling-down. Present study suggested that the decrease of intraerythrocytic pH, which is easily deduced from urinary bicarbonate, might be important as a fatigue factor after heavy exercise.

我们调查了健康成年男性在定量和剧烈运动（局部和全身重复运动）期间和运动结束后各种生理因素，血乳酸，尿氮氧化物，尿碳酸氢盐和尿pH值的变化。此外，我们研究了冷却运动对这些生理参数的变化后，终止大强度运动的影响。在此基础上，推导出血NO、血碳酸氢盐、血pH和红细胞pH的动态变化，并对这些参数的生理意义和运动医学意义进行了考察，结果发现，运动结束后3h内尿碳酸氢盐增加，结果表明，运动后血乳酸代谢为二氧化碳，其在血液中进一步代谢为碳酸氢盐。Biclidine最终经尿液排泄。随着这些反应的进行，大量的氢离子留在红细胞中，导致血红蛋白的氧亲和力降低，最终引起全身性发绀。这些过程可以被认为与剧烈运动后的疲劳有关。当引入降温运动时，没有观察到尿碳酸氢盐的增加，这表明通过降温可以改善体内环境。目前的研究表明，红细胞内pH值的下降，这是很容易推断出的尿碳酸氢盐，可能是一个重要的疲劳因素后，剧烈运动。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

β2-Agonist, clenbuterol induced distribution changes of the number of white blood cells in rats

β2受体激动剂克仑特罗引起大鼠白细胞数量分布变化

DOI：
发表时间：
2007
期刊：
J.Pharmacol.Sci. (in press)
影响因子：
0
作者：
K.Shirato;A.Tomoda;K.Imaizumi
通讯作者：
K.Imaizumi

Significance of post-exercise increment of urinary bicarbonate and pH in subjects loaded with submaximal cycling exercise

进行次最大自行车运动的受试者运动后尿碳酸氢盐和 pH 值增加的意义

DOI：
发表时间：
2004
期刊：
Tohoku J.Exp.Med. 202
影响因子：
0
作者：
T.Moriguchi;A.Tomoda;S.Ichimura;Y.Odagiri;S.Inoue;T.Nagasawa;H.Tanaka;N.Nakagawa;T.Shimomitsu
通讯作者：
T.Shimomitsu

Significance of post-exercise increment of urinary bicarbonate and pH

运动后尿碳酸氢盐和 pH 值增加的意义