GRK 1121: Genetic and Immunologic Determinants of Pathogen-Host-Interactions

GRK 1121：病原体-宿主相互作用的遗传和免疫决定因素

• 批准号: 462190
• 金额: --
• 依托单位: Robert Koch-Institut (RKI)
• 依托单位国家: 德国
• 项目类别: Research Training Groups
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/462190?language=en
• 关键词: GRK; 1121; Genetic; Immunologic; Determinants

The Research Training Group (RTG) works on molecular aspects of the interaction between pathogens, i.e. viruses, bacteria and eukaryotic parasites, and their hosts. All of these parasites have in common that they evolved intricate mechanisms to enter their host, and to survive and multiply within the presence of an efficient immune system. In spite of these common denominators, research in the disciplines of virology, microbiology and parasitology is still relatively narrowly focused on their own respective fields.

研究培训小组(RTG)从事病原体(即病毒、细菌和真核寄生虫)与其宿主之间相互作用的分子方面的工作。所有这些寄生虫的共同点是，它们进化出复杂的机制进入宿主，并在有效的免疫系统存在下生存和繁殖。尽管有这些共同点，但病毒学、微生物学和寄生虫学学科的研究仍然相对狭隘地集中在各自的领域。

项目成果

Marek's Disease Viral Interleukin-8 Promotes Lymphoma Formation through Targeted Recruitment of B Cells and CD4+ CD25+ T Cells

• DOI: 10.1128/jvi.00556-12
• 发表时间: 2012-08-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Engel, Annemarie T.;Selvaraj, Ramesh K.;Kaufer, Benedikt B.
• 通讯作者: Kaufer, Benedikt B.

Conditional Mutagenesis of a Novel Choline Kinase Demonstrates Plasticity of Phosphatidylcholine Biogenesis and Gene Expression in Toxoplasma gondii*

新型胆碱激酶的条件诱变证明弓形虫中磷脂酰胆碱生物发生和基因表达的可塑性*

• DOI: 10.1074/jbc.m112.347138
• 发表时间: 2012
• 期刊: The Journal of Biological Chemistry
• 作者: Sampels V;Hartmann A;Dietrich I;Coppens I;Sheiner L;Striepen B;Herrmann A;Lucius R;Gupta N
• 通讯作者: Gupta N

Broad geographical distribution and high genetic diversity of shrew-borne Seewis hantavirus in Central Europe

• DOI: 10.1007/s11262-012-0736-7
• 发表时间: 2012-08-01
• 期刊: VIRUS GENES
• 影响因子: 1.6
• 作者: Schlegel, Mathias;Radosa, Lukas;Ulrich, Rainer G.
• 通讯作者: Ulrich, Rainer G.

Highly Restricted Usage of Ig H Chain VH14 Family Gene Segments in Slp65-Deficient Pre-B Cell Leukemia in Mice

• DOI: 10.4049/jimmunol.1201440
• 发表时间: 2012-11
• 期刊: The Journal of Immunology
• 作者: V. Ta;Marjolein J. W. de Bruijn;Louise S. Matheson;M. Zoller;M. P. Bach;H. Wardemann;H. Jumaa;A. Corcoran;R. Hendriks

The impact of a pathogenic bacterium on a social carnivore population

• DOI: 10.1111/j.1365-2656.2011.01873.x
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF ANIMAL ECOLOGY
• 影响因子: 4.8
• 作者: Hoener, Oliver P.;Wachter, Bettina;East, Marion L.
• 通讯作者: East, Marion L.