Effects of bean resistant starches and mushroom fibers on lipid metabolism in rats.

豆类抗性淀粉和蘑菇纤维对大鼠脂质代谢的影响。

• 批准号: 15580098
• 负责人: FUKUSHIMA Michihiro
• 金额: $ 1.66万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine, Faculty of Animal Husbandry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15580098/
• 关键词: rats; bean (adzuki, kintoki, tebou); mushroom (shiitake, enokitake, maitake); dietary fiber; resistant starch; polyphenol; cholesterol metabolism; shory chain fatty acid; 雑豆(アズキ、キントキ、テボウ); きのこ(シイタケ、エノキタケ、マイタケ); アズキ; キントキ; テボウ; コレステロール; 胆汁酸 /

1.The hypocholesterolemic effects in rats fed the enzyme-resistant fractions of adzuki, kintoki and tebou beans were evident compared with rats fed a cellulose diet. The enzyme-resistant fractions elevated fecal acidic steroid excretions, and reduced the serum total cholesterol, HDL-cholesterol, and VLDL + IDL + LDL-cholesterol concentrations. It appears that the cholesterol-lowering effect of enzyme-resistant fractions is due to the enhanced cholesterol 7α-hydroxylase mRNA level in the adzuk, kintoki and tebou groups, SR-B1 mRNA level in the adzuki group, and fecal steroid excretion accelerated by SCFA in the adzuk, kintoki and tebou groups.2.It was suppressed the acetaminophen-induced hepatotoxicity in rats administrated a water extract of adzuki bean hulls, by the lowering of serum aspartate aminotransferase activity and hepatic lipid peroxide concentration, and by the increasing of hepatic GSH concentration, GSH reductase and catalase activities. The results of this study demonstrate the protective action of the water extract of adzuki bean hulls against acetaminophen-induced hepatotoxicity via the hepatic GSH antioxidant/detoxification system in rats. However, the hepatoprotective mechanism and the active components of the adzuki bean water extract require further investigation.3.The serum cholesterol lowering effects in rats of the mushroom fibers were evident compared with rats fed cellulose. The fibers elevated the hepatic LDL receptor mRNA level in the enokitake fiber group, reduce the HDL-cholesterol concentration in the enokitake group and enhance the fecal cholesterol excretion in the maitake fiber and enokitake fiber groups. The results demonstrate that ingestion of the maitake-and enokitake-fibers attenuated increases in the serum total cholesterol and VLDL + IDL + LDL-cholesterol concentrations in test rats.

1.与饲喂纤维素饲料的大鼠相比，饲喂小豆、小豆和豆角的抗酶部分的大鼠具有明显的降胆固醇作用。抗酶组分增加粪便酸性类固醇排泄量，降低血清总胆固醇、高密度脂蛋白-胆固醇和极低密度脂蛋白+低密度脂蛋白+低密度脂蛋白的浓度。说明红豆皮抗酶部位的降胆固醇作用可能是通过提高阿祖克、红木和豆腐的胆固醇7α-羟基酶的基因水平，提高红木的SR-B1mRNA水平，以及红豆的超氧化物歧化酶促进粪便类固醇的排泄所致。2.红豆皮水提物可降低血清天冬氨酸氨基转移酶活性和肝脏脂质过氧化水平，提高肝脏谷胱甘肽含量、谷胱甘肽还原酶和过氧化氢酶活性，从而抑制醋氨酚诱导的大鼠肝毒性。本研究结果表明，红豆壳水提物对醋氨酚所致大鼠肝损伤有保护作用，其机制可能与肝脏GSH抗氧化/解毒系统有关。然而，赤小豆水提取物的保肝机理和活性成分有待进一步研究。3.与饲喂纤维素的大鼠相比，蘑菇纤维对大鼠血清胆固醇的降低作用明显。高密度脂蛋白受体基因表达增加，高密度脂蛋白胆固醇浓度降低，高密度脂蛋白排泄量增加。结果表明，大鼠摄入大麦纤维和大麦纤维后，大鼠血清总胆固醇和极低密度脂蛋白+低密度脂蛋白+低密度脂蛋白-胆固醇浓度均有所降低。

项目成果

煮豆の効能-難消化性澱粉はコレステロールを低下させるか?-

煮豆子的好处——抗性淀粉能降低胆固醇吗？

• 发表时间: 2004
• 期刊: 化学と生物 42・6
• 作者: Kyu-Ho Han;Michihiro Fukushima;Kiyoshi Ohba;Ken-ichiro Shimada;Mitsuo Sekikawa;Hideyuki Chiji;Chi-Ho Lee;Masuo Nakano;福島道広
• 通讯作者: 福島道広

Kyu-Ho Han, Michihiro Fukushima, Kozue Shimizu, Michiyuki Kojima, Kiyoshi Ohba, Akira Tanaka, Ken-ichiro Shimada, Mitsuo Sekikawa, Masuo Nakano: "Resistant starches of beans reduced the serum cholesterol concentration in rats"Journal of Nutritional Scienc

Kyu-Ho Han、Michihiro Fukushima、Kozue Shimizu、Michiyuki Kojima、Kiyoshi Ohba、Akira Tanaka、Ken-ichiro Shimada、Mitsuo Sekikawa、Masuo Nakano：“豆类抗性淀粉降低了大鼠的血清胆固醇浓度”营养科学杂志

Effect of dietary fiber of some beans on serum cholesterol concentration in rats

部分豆类膳食纤维对大鼠血清胆固醇浓度的影响

• 发表时间: 2004
• 期刊: Food Science and Biotechnology 13・2
• 作者: Kyu-Ho Han;Tetsu Ohashi;Michiyuki Kojima;Michihiro Fukushima
• 通讯作者: Michihiro Fukushima

Functions of boiled beans -Are resistant starches of bean lowered serum cholesterol concentration?-

煮豆子的功效 -豆子中的抗性淀粉是否可以降低血清胆固醇浓度？-

• 发表时间: 2004
• 期刊: Kagaku to Seibutsu Vol.42, No.6
• 作者: Kyu-Ho Han;Michihiro Fukushima;Kiyoshi Ohba;Ken-ichiro Shimada;Mitsuo Sekikawa;Hideyuki Chiji;Chi-Ho Lee;Masuo Nakano;Michihiro Fukushima
• 通讯作者: Michihiro Fukushima

Kyu-Ho Han, Michihiro Fukushima, Teruhiko Kato, Michiyuki Kojima, Kiyoshi Ohba, Ken-ichiro Shimada, Mitsuo Sekikawa, Masuo: "Enzyme-resistant fraction of beans lowered serum cholesterol, and increased sterol excretions and hepatic mRNA levels in rats"Lipi

Kyu-Ho Han、Michihiro Fukushima、Teruhiko Kato、Michiyuki Kojima、Kiyoshi Ohba、Ken-ichiro Shimada、Mitsuo Sekikawa、Masuo：“豆类的酶抗性部分可降低大鼠的血清胆固醇，并增加甾醇排泄和肝脏 mRNA 水平”Lipi