Photoreceptor proliferation in the mature retina and pineal organ of the teleost fish.
硬骨鱼成熟视网膜和松果体中光感受器的增殖。
基本信息
- 批准号:15580161
- 负责人:
- 金额:$ 2.3万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1)In parallel with histological observation on the increase in number of the rod cells, the distribution of proliferating cell nuclear antigen (PCNA)-immunoreactive cells was investigated in the mature retina of the teleost fish. A great number of PCNA-immunoreactive cells were demonstrated in both the outer and inner nuclear layers in the adult retina of the river eel Anguilla japonica migrating thousands of kilometers to breed in the ocean, and throughout the outer nuclear layer in the juvenile retina of the lefteye flounder Paralichthys olivaceus adapted to the benthic habitat and nocturnal feeding. These results suggest that the retinal rod cells proliferate throughout their life, following migration of the rod precursors from the progenitor clusters in the inner nuclear layer in the eel and from the basal to the apical region in the outer nuclear layer in the flounder.2)Together with opsin-immunoreactive photoreceptor outer segments, a tremendous number of PCNA-immunoreactive cells were demonstrated throughout the end-vesicle and stalk in the pineal organ of the 2 years-old rainbow trout Oncorhynchus mykiss lacking a circadian clock of melatonin synthesis. No or little coexistence of PCNA and opsin was demonstrated, although the close approaches of opsin-positive photoreceptor outer segments and PCNA-immunoreactive cells were found sometimes. These findings suggested that the pineal photoreceptor cells also proliferate in the adult rainbow trout, thus keeping highly sensitive signal-transduction mechanisms for active melatonin synthesis.
(1)在组织学观察视杆细胞数量增加的同时,观察了增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)免疫反应阳性细胞在硬骨鱼成熟视网膜中的分布。在远游数千公里的日本鳗鲡(Anguilla japonica)成体视网膜的外核层和内核层,以及适应底栖和夜间摄食的牙鲆(Paralichthys olivaceus)幼鱼视网膜的外核层,均发现了大量的PCNA免疫反应阳性细胞。这些结果表明视网膜视杆细胞在其整个生命过程中增殖,视杆前体细胞在鳗鱼的内核层中从祖细胞群迁移,在比目鱼的外核层中从基底区迁移到顶端区。在缺乏褪黑激素合成昼夜节律钟的2岁虹鳟鱼松果体中,在整个末端囊泡和柄中显示出大量的PCNA免疫反应细胞。视蛋白阳性的感光细胞外节与PCNA免疫反应阳性细胞有时接近,但两者几乎不共存。这些结果表明,松果体感光细胞也增殖的成年虹鳟鱼,从而保持高度敏感的信号转导机制,积极褪黑激素的合成。
项目成果
期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rod cells proliferate in the eel retina throughout the life.
杆状细胞在鳗鱼视网膜中终生增殖。
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Omura;Y.
- 通讯作者:Y.
Distribution of proliferating cell nuclear antigen-immunoreactive cells in the mature...
增殖细胞核抗原免疫反应细胞在成熟细胞中的分布
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Omura;Y.
- 通讯作者:Y.
Distribution of proliferating cell nuclear antigen-immuno-reactive cells in the mature retina and pineal organ of the teleost fish.
硬骨鱼成熟视网膜和松果体中增殖细胞核抗原免疫反应细胞的分布。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Omura;Y.
- 通讯作者:Y.
Omura, Y: "Rod cells proliferate in the eel retina throughout the life"Fisheries Science. 69・5. 924-928 (2003)
Omura, Y:“视杆细胞在鳗鱼视网膜中增殖”,渔业科学 69・5(2003)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Distribution of proliferating cell nuclear antigen-immunoreactive cells in the mature retina and pineal organ of the teleost fish.
硬骨鱼成熟视网膜和松果体中增殖细胞核抗原免疫反应细胞的分布。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Omura;Y.
- 通讯作者:Y.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
OMURA Yuri其他文献
OMURA Yuri的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('OMURA Yuri', 18)}}的其他基金
Neurogenesis of Photoreceptor Cells in the Pineal Organ and Retina of the Adult Fish
成鱼松果体和视网膜感光细胞的神经发生
- 批准号:
17580162 - 财政年份:2005
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Immunocytochemical Study of the Functional Development and Differentiation in the Photoreceptor Organs of Fishes
鱼类感光器官功能发育和分化的免疫细胞化学研究
- 批准号:
12660167 - 财政年份:2000
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
The mechanisms of lymphocystis cell formation in Japanese flounder Paralichthys olivaceus experimentally infected with lymphocystis disease virus
实验感染淋巴囊肿病毒的牙鲆淋巴细胞形成机制
- 批准号:
23780195 - 财政年份:2011
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development and an application of a PCR-baaed method for the identification of cosumed Japanese flounder, Paralichthys olivaceus, juveniles form the gut contents of crustacean predators
基于 PCR 的方法的开发和应用,用于鉴定食用的日本牙鲆、牙鲆、甲壳类捕食者肠道内容物的幼鱼
- 批准号:
14560160 - 财政年份:2002
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)