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The monoaminergic modulation of spinal motor function and the alteration in the motor disease

脊髓运动功能的单胺能调节和运动疾病的改变

基本信息

批准号：
15590134
负责人：
ONO Hideki
金额：
$ 2.3万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

The descending noradrenergic and serotonergic systems modulate the function of the spinal α-motoneurons which control movements of body and limbs. However, the function and changes in neuronal disease are unclear. In the present study, the following results were obtained.1. Serotonergic agonists have been shown both to increase and decrease spinal motor transmission. Motoneurons possess somatodendritic serotonin (5-HT)_2 receptors, which account for the increased excitability. However, it is unclear which receptor subtypes mediate the inhibitory effects on spinal reflexes. We showed that 5-HT_<1B> and 5-HT_<1D> receptors located in the spinal cord mediate the 5-HT-induced inhibition of spinal reflexes.2. Spinal reflexes and recurrent and presynaptic inhibitions in streptozotocin (STZ)-induced diabetic rats were examined. The recurrent inhibition which is mediated by glycine was depressed in diabetic rats. In addition, the inhibitory effect of 5-HT was decreased in those rats. These res … More ults show that the diabetogenic degeneration occurred in not only sensory but also motor systems.3. The relationships between ataxia and the monoamines concentrations of central nervous systems were examined in spinocerebellar atrophy (SCD) model mice. Two SCD model mice, rolling mouse Nagoya (RMN) and Ara-C mice which were produced by the administration of cytosine arabinoside on 2, 3, 4 days after birth, were used. The concentrations of monoamines were increased in CNS of these SCD model mice. The repeated administration of taltirelin hydrate, which is clinically used for SCD treatment, improved ataxia, but did not affect the monoamines concentration of CNS in RMN and Ara-C mice.4. We showed that the noxious stimuli-evoked flexor reflex of mice were composed from Aδ-fiber mediated short-latency and C-fiber-mediated long-latency withdrawal movements. These withdrawal movements are facilitated by repeated stimulation, it is called wind-up. In STZ-induced diabetic mice, the wind-up of C-fiber-mediated movement, but not Aδ-fiber-mediated one, was enhanced significantly. Less

下行的去甲肾上腺素能和肾上腺素能系统调节脊髓α运动神经元的功能，后者控制身体和肢体的运动。然而，神经元疾病的功能和变化尚不清楚。在本研究中，获得了以下结果. 5-羟色胺能激动剂已显示增加和减少脊髓运动传递。运动神经元具有5-羟色胺（5-HT）_2受体，这是运动神经元兴奋性增强的原因。然而，目前还不清楚哪些受体亚型介导脊髓反射的抑制作用。结果表明，脊髓内的5-HT_2<1B>和5-HT_3<1D>受体介导了5-HT对脊髓反射的抑制作用.本实验观察了链脲佐菌素（STZ）诱导的糖尿病大鼠脊髓反射和突触前抑制。甘氨酸介导的再发抑制在糖尿病大鼠中被抑制。此外，5-HT的抑制作用在这些大鼠中降低。这些re ...更多信息结果显示糖尿病性退行性变不仅发生在感觉系统，也发生在运动系统.本研究以脊髓小脑萎缩（SCD）小鼠为模型，探讨了共济失调与中枢神经系统单胺类递质的关系。采用出生后2、3、4天给予阿糖胞苷制备的两种SCD模型小鼠，滚动小鼠名古屋（RMN）和Ara-C小鼠。SCD模型小鼠中枢神经系统单胺类神经递质浓度升高。临床上用于SCD治疗的他替瑞林水合物重复给药可改善RMN和Ara-C小鼠的共济失调，但不影响CNS单胺浓度.结果表明，伤害性刺激诱发的小鼠屈肌反射由Aδ纤维介导的短潜伏期和C纤维介导的长潜伏期缩足运动组成。这些撤退运动是由反复刺激促进的，它被称为发条。在STZ诱导的糖尿病小鼠中，C-纤维介导的运动而不是Aδ-纤维介导的运动的卷起显著增强。少