Spinal Cord Injury : Establishment of Measurement for Electrophysiological Function and Pharmacological Evaluation of Drugs

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This study aimed 1) to search effective drugs for the treatment of spinal cord injury (SCI) from clinically used therapeutics, 2) to establish evaluation method of nerve degeneration and/or renervation after SCI in electrophysiological function, and 3) to study effectiveness of selected drugs on protection and/or treatment of SCI in physiological function. The antidiabetic pioglitazone recovered motor disorder and prevented the appearance of neuropathic pain, and it prevented or recovered the electrophysiological function of descending serotonergic fibers to spinal motor systems.