DREADD Manipulations of Drug Choice
药物选择的可怕操纵
基本信息
- 批准号:10574862
- 负责人:
- 金额:$ 5.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AgonistAmphetaminesAnimalsBasal GangliaCardiovascular systemChronicClinical DataCocaineCocaine AbuseCocaine DependenceCocaine use disorderDataDevelopmentDiseaseDopamineDoseDrug ModulationEffectivenessExtinctionFemaleFiberFoodGeneticHealthHumanLigandsMaintenanceMeasuresMediatingMethodsMicrodialysisNeurobiologyNeurosciences ResearchNeurotransmittersNorepinephrineNucleus AccumbensOsmosisOverdosePathway interactionsPharmaceutical PreparationsPharmacotherapyPhotometryPlayProceduresPsychological reinforcementPublic HealthPublishingPumpRattusRecoveryResearch SupportRoleSprague-Dawley RatsStimulantSynapsesTestingTrainingTransgenic OrganismsTwin Multiple BirthUnited StatesUnited States Food and Drug AdministrationVentral Tegmental AreaViralVirus Diseasesabuse liabilityawakecareer developmentcocaine self-administrationdesigner receptors exclusively activated by designer drugsdopamine transporterdrug seeking behavioreffective therapyimprovedin vivoinhibitorinnovationmaleneurochemistryneurotransmissionneurotransmitter releasenoradrenaline transporternovelopioid use disorderpre-clinical researchpre-doctoralreinforced behaviorserotonin transportersmall moleculetheoriestooltreatment effect
项目摘要
Project Summary
Cocaine abuse and addiction remain a persistent health problem both in the United States and worldwide. There
are currently no Food and Drug administration-approved pharmacotherapies for cocaine use disorder.
Amphetamine maintenance has shown promise as an effective treatment for cocaine abuse, but abuse liability
and cardiovascular concerns make it unlikely to be approved as a treatment option. Additionally, the mechanism
by which amphetamine functions in this context is unknown; however, amphetamine maintenance has been
shown to blunt cocaine-induced dopamine increases in the nucleus accumbens (NAc). This proposal will
determine the role of mesocorticolimbic dopamine pathway and dopamine tone in modulating cocaine
reinforcement and cocaine-induced increases in mesolimbic dopamine. The premise of this project is that the
mesocorticolimbic VTA dopamine pathway plays a significant role in the modulation of drug seeking behavior.
Aim 1 will determine the effects of stimulatory DREADDs in the VTA on cocaine choice. Male and female TH:Cre
transgenic Sprague-Dawley rats will be virally infected with DREADDs and trained on a cocaine-vs-food choice
procedure. Animals will be chronically administered a DREADD agonist via osmotic pump to activate DREADDs
and determine their effect on cocaine choice. Aim 2 will determine the neurochemical effects of stimulatory and
inhibitory DREADD activation both alone and on cocaine-induced increases in NAc dopamine. Following
recovery from viral infection of DREADDs, animals will be repeatedly administered a DREADD agonist. Basal
NAc dopamine levels and changes in dopaminergic tone following cocaine administration will be measured via
in vivo fiber photometry (e.g. dLight). Overall, this proposal will help improve mechanistic understanding of
cocaine reinforcement and guide development of more effective cocaine use disorder treatments.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Hannah Robinson其他文献
Hannah Robinson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Relationship between neurotoxicity and the chemical structures of amphetamines
安非他明的神经毒性与化学结构的关系
- 批准号:
25860103 - 财政年份:2013
- 资助金额:
$ 5.27万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Search for protein expression in amphetamines treated mouse heart : Challenge to the diagnosis for the sudden death of amphetamines abusers
寻找安非他明治疗小鼠心脏中的蛋白质表达:对安非他明滥用者猝死诊断的挑战
- 批准号:
22659138 - 财政年份:2010
- 资助金额:
$ 5.27万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
用于治疗安非他明滥用/疾病的新型功能选择性血清素 5HT2 药物
- 批准号:
8312648 - 财政年份:2010
- 资助金额:
$ 5.27万 - 项目类别:
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
用于治疗安非他明滥用/疾病的新型功能选择性血清素 5HT2 药物
- 批准号:
8531900 - 财政年份:2010
- 资助金额:
$ 5.27万 - 项目类别:
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
用于治疗安非他明滥用/疾病的新型功能选择性血清素 5HT2 药物
- 批准号:
8715749 - 财政年份:2010
- 资助金额:
$ 5.27万 - 项目类别:
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/Disorder
用于治疗安非他明滥用/疾病的新型功能选择性血清素 5HT2 药物
- 批准号:
8144930 - 财政年份:2010
- 资助金额:
$ 5.27万 - 项目类别:
Translational Genetics and Dopamine Signaling in Sensitivity to Amphetamines
安非他明敏感性中的转化遗传学和多巴胺信号传导
- 批准号:
7675601 - 财政年份:2009
- 资助金额:
$ 5.27万 - 项目类别:
Simultaneous determination of ephedrines, amphetamines, cocaine, cocaine metabolites, and opiates and interaction in the rat
大鼠体内麻黄碱、安非他明、可卡因、可卡因代谢物和阿片类药物的同时测定及其相互作用
- 批准号:
17590585 - 财政年份:2005
- 资助金额:
$ 5.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study for practical use of two chiral analyses of amphetamines by gas chromatography-mass spectrometry
气相色谱-质谱法对苯丙胺两种手性分析的实用化研究
- 批准号:
17590588 - 财政年份:2005
- 资助金额:
$ 5.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines
3,4-亚甲二氧基安非他明的临床药理学
- 批准号:
6870119 - 财政年份:2004
- 资助金额:
$ 5.27万 - 项目类别: