Association of antioxidants with inflammation and atherosclerosis a baseline study

抗氧化剂在预防糖尿病血管并发症中是潜在有益的，因为氧化应激在这种情况下会增强，并在血管疾病中发挥重要作用。本研究的目的是调查是否臂踝脉搏波速度（baPWV）将在存在高血清类胡萝卜素浓度分层根据血糖状态较低。共有297名男性和579名女性，年龄在30至70岁之间，进行了横断面分析。血糖正常时，β-胡萝卜素最高三分位数baPWV（1386 cm/s）的多元校正均值低于最低三分位数baPWV（1432 cm/s），而β-隐黄素最高三分位数baPWV（1382 cm/s）的多元校正均值低于中间三分位数baPWV（1424 cm/s）。在一组包括持续葡萄糖受损和糖尿病的受试者中观察到类似的负相关，但无统计学意义。类胡萝卜素的最高三分位数与高baPWV（=<1680 cm/s）的低风险相关。β-胡萝卜素和β-隐黄质的年龄、性别和血糖状态校正比值比分别为0.35（95%CI 0.20 - 0.60）和0.45（0.27 - 0.77）。多变量调整没有改变结果。总之，观察到baPWV与β-胡萝卜素和β-隐黄质的负相关性与血糖状态无关。

Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for β-carotene (1386 cm/s) was bwer than that in the lowest tertile (1432 cm/s) and that in the highest tertile for β-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal festing glucose. Similar inverse associations were observed in a group that included subjects with both impaired lasting glucose and diabetes, however, without statistical significance. The highest tertile ofcarotenoids was associated with a low risk for high baPWV (=<1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for β-carotene and 0.45 (0.27-0.77) for β-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with β-carotene and β-cryptoxanthin was observed independently of the glycemic state.