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Association of antioxidants with inflammation and atherosclerosis a baseline study

抗氧化剂与炎症和动脉粥样硬化关联的基线研究

基本信息

批准号：
15590544
负责人：
NAKAMURA Mieko
金额：
$ 2.43万
依托单位：
National Institute for Longevity Sciences (2004)Hamamatsu University School of Medicine (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for β-carotene (1386 cm/s) was bwer than that in the lowest tertile (1432 cm/s) and that in the highest tertile for β-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal festing glucose. Similar inverse associations were observed in a group that included subjects with both impaired lasting glucose and diabetes, however, without statistical significance. The highest tertile ofcarotenoids was associated with a low risk for high baPWV (=<1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for β-carotene and 0.45 (0.27-0.77) for β-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with β-carotene and β-cryptoxanthin was observed independently of the glycemic state.

抗氧化剂在预防糖尿病血管并发症方面有潜在的好处，因为在这种情况下，氧化应激会增强，并在血管疾病中发挥重要作用。本研究旨在研究根据血糖状态分层的高血清类胡萝卜素浓度是否会降低臂踝脉搏波速度(BaPWV)。共有297名年龄在30岁到70岁之间的男性和579名女性接受了横截面分析。在血糖正常的情况下，β-胡萝卜素最高三分位数(1386 cm/S)高于最低三分位数(1432 cm/S)，β-隐黄素最高三分位数(1382 cm/S)低于中三分位数(1424 cm/S)。然而，在包括持久血糖受损和糖尿病的受试者的一组中，观察到了类似的反向关联，但没有统计学意义。类胡萝卜素含量最高的三分位数与高BaPWV的风险较低(=&lt；1680 cm/S)。年龄、性别和血糖状态调整后的优势比β-胡萝卜素为0.35(95%CI 0.20-0.60)，β-隐黄素为0.45(0.27-0.77)。多变量调整没有改变结果。总而言之，β-胡萝卜素和β-隐黄质与BaPWV呈负相关，与血糖状态无关。