Association of antioxidants with inflammation and atherosclerosis a baseline study

抗氧化剂在预防糖尿病血管并发症方面具有潜在的益处，因为在这种情况下氧化应激会增强，并在血管疾病中发挥重要作用。本研究旨在探讨根据血糖状态分层的高血清类胡萝卜素浓度是否会降低臂踝脉搏波速度（baPWV）。共有297名男性和579名女性在30至70岁之间进行了横断面分析。在血糖正常的情况下，β-胡萝卜素最高分蘖（1386 cm/s）的baPWV多因素校正平均值低于最低分蘖（1432 cm/s）， β-隐黄质最高分蘖（1382 cm/s）的baPWV低于中间分蘖（1424 cm/s）。类似的负相关在包括持久血糖受损和糖尿病患者的一组中也观察到，然而，没有统计学意义。类胡萝卜素含量越高，发生高baPWV的风险越低（=<1680 cm/s）。年龄、性别和血糖状态调整后的比值比β-胡萝卜素为0.35 (95% CI 0.20-0.60)， β-隐黄质为0.45（0.27-0.77）。多变量调整没有改变结果。综上所述，baPWV与β-胡萝卜素和β-隐黄质呈负相关，与血糖状态无关。

Antioxidants are potentially beneficial in preventing vascular complications in diabetes because oxidative stress would be enhanced in such a condition and play an important role in vascular disorders. This study aimed to investigate whether brachial-ankle pulse wave velocity (baPWV) would be lower in the presence of high serum carotenoid concentrations stratified according to the glycemic state. A total of 297 men and 579 women between 30 and 70 years of age were analyzed cross-sectionally. Multivariate adjusted mean of baPWV in the highest tertile for β-carotene (1386 cm/s) was bwer than that in the lowest tertile (1432 cm/s) and that in the highest tertile for β-cryptoxanthin (1382 cm/s) was lower than that in the middle tertile (1424 cm/s) in the case of normal festing glucose. Similar inverse associations were observed in a group that included subjects with both impaired lasting glucose and diabetes, however, without statistical significance. The highest tertile ofcarotenoids was associated with a low risk for high baPWV (=<1680 cm/s). Age, sex and glycemic state adjusted odds ratio was 0.35 (95% CI 0.20-0.60) for β-carotene and 0.45 (0.27-0.77) for β-cryptoxanthin. Multivariate adjustment did not alter the results. In conclusion, an inverse association of baPWV with β-carotene and β-cryptoxanthin was observed independently of the glycemic state.