Chlamydia pneumoniae infection and incident coronary heart disease

肺炎衣原体是衣原体属的第三种，常引起社区获得性呼吸道感染，如咽炎、支气管炎和肺炎。在日本成年人中，这种微生物的血清阳性率为50%-70%，大多数人被认为在一生中感染了几次。最近的血清表皮病学研究表明慢性肺炎衣原体感染与心脏病的发生有关。肺炎衣原体慢性感染可能是冠心病的危险因素之一。本文将对文献进行综述。一项关于50-70岁男性茨城县人群心血管疾病危险因素的病例对照研究被调查。对104例颈总动脉IMT>1.1 mm、颈内动脉IMT>1.5 mm的受试者进行血清流行病学调查，观察肺炎衣原体感染与动脉粥样硬化的关系。颈动脉硬化组IgA指数明显高于对照组(颈总动脉IMT为1.1 mm，颈内动脉为1.5 mm，n=104)。新城疫螺旋体反复连续感染可使IgA指标值升高。这一结果表明肺炎衣原体感染是动脉硬化症的一个危险因素。

Chlanzydia pneunnoniae infection and incident coronary heart diseaseChlanydia pnewnoniae is the third species of the genus Chlamydia and frequently causes community-acquired respiratory tract infections such as pharyngitis, bronchitis, and pneumonia. Seroprevalence of this organism is 50-70% in Japanese adults, and most people are thought to be infected several times in their lifetime. Recent seroepiderniologic studies suggest a relationship between chronic C. pneumoniae infection and incident heart disease. The chronic C. pnewnoniae infection maybe a risk factor for coronary heart disease. This presentation will give a review of the literature.A case-control study concerning of risk factor of cardiovascular disease in Ibaraki lural population aged 50-70 men was investigated. Relationship between C. pnewnoniae infection and atherosclerosis was observed by seroepidemiologically 104 participantswith over 1.1 mm IMT of total carotid and 1.5 mm of internal carotid(case). Compared with controls (<1.1 mm IMT of total carotid and <1.5 mm of internal carotid, n =104), case with sclerosis of the carotid had higher IgA index values significantly. Repetitive and continuous infection of the C. pnewnoniae may increase the IgA index value. This result suggests that Ce pnewnoniae infection is a risk factor of athrosclerosis.