The role of PPAR γ in Gastrointestinal disease

PPARγ 在胃肠道疾病中的作用

• 批准号: 15590669
• 负责人: NAKAJIMA Atsushi
• 金额: $ 2.3万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590669/
• 关键词: PPARγ; cre-lox; Fabp; 性腸疾患; 炎症性腸疾患

The purpose of this research is to clarify the role of PPARγ-intestinal disease, especially the association with colon cancer carcinogenesis and Inflammatory Bowel Disease. In this research, we made the conditional knockout mouse of PPARγ in intestine (using cre-lox system). The intestine specific promoter Fatty Acid Binding Protein (FABP) was used for cre-transgenic mouse, also we created the lox-PPAR transgenic mouse. We are now analyzing cre-lox-PPARγ conditional.

本研究旨在阐明PPARγ在肠道疾病中的作用，特别是与结肠癌癌变和炎症性肠病的关系。本研究利用cre-lox系统建立了肠内PPARγ条件性基因敲除小鼠模型。将肠特异性启动子脂肪酸结合蛋白（FABP）用于cre转基因小鼠，建立了lox-PPAR转基因小鼠。我们现在分析cre-lox-PPARγ条件。

项目成果

Chen D: "Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function"J Immunol. Mar 15;172(6). 3535-3543 (2004)

Chen D：“癌胚抗原相关细胞粘附分子1亚型交替抑制和共刺激人类T细胞功能”JImmunol。

Marked attenuation of production of collagen type I from cardiac fibroblasts by dehydroepiandrosterone

• DOI: 10.1152/ajpendo.00370.2004
• 发表时间: 2005-06-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
• 影响因子: 5.1
• 作者: Iwasaki, T;Mukasa, K;Nakajima, A
• 通讯作者: Nakajima, A

Efficacy of a Triple Therapy with Rabeprazole, Amoxicilin, and Faropenem as second-line Treatment after Failure of Initial Helicobacter pylori Eradication Therapy

初始幽门螺杆菌根除治疗失败后雷贝拉唑、阿莫西林和法罗培南三联疗法作为二线治疗的疗效

• 发表时间: 2005
• 期刊: Hepato-Gastroenterology 52
• 作者: Togawa J;Inamori M;Fujisawa N;Takahashi H;Yoneda M;Kawamura H;Abe Y;Kirikoshi H;Kobayashi N;Sakaguchi T;Takamura T;Nakajima A;Ueno N;Sekihara H
• 通讯作者: Sekihara H

Nuclear Receptors as Targets for Drug Development: Preface

核受体作为药物开发的靶标：前言

• 发表时间: 2005
• 期刊: Journal of Pharmacological Sciences 97
• 作者: Nakajima A;Wada K
• 通讯作者: Wada K

Nakajima A: "PPARγ-gene therapy using an adenovirus vector for inflammatory bowel disease"Folia Pharmacol.Jpn.. 122. 309-316 (2003)

Nakajima A：“使用腺病毒载体治疗炎症性肠病的 PPARγ 基因疗法”Folia Pharmacol.Jpn.. 122. 309-316 (2003)