The role of PPAR γ in Gastrointestinal disease
The role of PPAR γ in Gastrointestinal disease
批准号:
15590669
负责人:
NAKAJIMA Atsushi
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2003
资助国家:
日本
项目状态:
已结题
起止时间:
2003 至 2004
中文摘要
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英文摘要
The purpose of this research is to clarify the role of PPARγ-intestinal disease, especially the association with colon cancer carcinogenesis and Inflammatory Bowel Disease. In this research, we made the conditional knockout mouse of PPARγ in intestine (using cre-lox system). The intestine specific promoter Fatty Acid Binding Protein (FABP) was used for cre-transgenic mouse, also we created the lox-PPAR transgenic mouse. We are now analyzing cre-lox-PPARγ conditional.
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Chen D: "Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function"J Immunol. Mar 15;172(6). 3535-3543 (2004)
Chen D:“癌胚抗原相关细胞粘附分子1亚型交替抑制和共刺激人类T细胞功能”JImmunol。
DOI:
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发表时间:
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DOI:
10.1152/ajpendo.00370.2004
发表时间:
2005-06-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
影响因子:
5.1
作者:
[Iwasaki, T, Mukasa, K, Nakajima, A]
通讯作者:
Nakajima, A
Efficacy of a Triple Therapy with Rabeprazole, Amoxicilin, and Faropenem as second-line Treatment after Failure of Initial Helicobacter pylori Eradication Therapy
初始幽门螺杆菌根除治疗失败后雷贝拉唑、阿莫西林和法罗培南三联疗法作为二线治疗的疗效
DOI:
--
发表时间:
2005
期刊:
Hepato-Gastroenterology 52
影响因子:
--
作者:
[Togawa J, Inamori M, Fujisawa N, Takahashi H, Yoneda M, Kawamura H, Abe Y, Kirikoshi H, Kobayashi N, Sakaguchi T, Takamura T, Nakajima A, Ueno N, Sekihara H]
通讯作者:
Sekihara H
Nuclear Receptors as Targets for Drug Development: Preface
核受体作为药物开发的靶标:前言
DOI:
--
发表时间:
2005
期刊:
Journal of Pharmacological Sciences 97
影响因子:
--
作者:
[Nakajima A, Wada K]
通讯作者:
Wada K
Nakajima A: "PPARγ-gene therapy using an adenovirus vector for inflammatory bowel disease"Folia Pharmacol.Jpn.. 122. 309-316 (2003)
Nakajima A:“使用腺病毒载体治疗炎症性肠病的 PPARγ 基因疗法”Folia Pharmacol.Jpn.. 122. 309-316 (2003)
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共 17 条
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