Establish the chemopreventive strategy using PPAR gamma ligands for colorectal cancer
Establish the chemopreventive strategy using PPAR gamma ligands for colorectal cancer
批准号:
18390222
负责人:
NAKAJIMA Atsushi
金额:
$10.95万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2007
中文摘要
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英文摘要
Activating synthetic ligands for PPARY, such as pioglitazone and rosiglitazone, are commonly used to treat patients with diabetes mellitus (DM) in order to improve insulin resistance. Several reports have clearly demonstrated that PPARY ligands, could inhibit colorectal cancer cell growth and induce apoptosis. On the other hands, the insulin resistance or hyper insulinemia are thought to be the one of the major risk factors of colorectal cancer (CRC). If hyper insulinemia, alone or in combination with other features of the insulin resistance syndrome, is associated with increased risk of CRC, activation of PPARY may play a benefited role in colon carcinogenesis. The results of clinical trials for CRC with PPARY ligands have shown modest This implies that aiming at PPARY as a specific anti-tumor target is not likely to be successful, because PPARY ligands are not an active agent for the treatment of advanced or metastatic CRC. Recently, we have demonstrated the substantial suppressive effects of PPARY ligands on colon carcinogenesis in mouse model in the early stage of carcinogenesis, suggesting a potential application as the chemopreventive agents against carcinogenesis. Furthermore, number of aberrant crypt foci, pre cancerous lesion of colorectal, was significantly decreased by PPARY ligand treatment in human study. PPARY ligands are used with safety benefit and may be a clinical application as anti-cancer drug in early stage of CRC. These results suggest that PPARY ligand is a promising candidate as a chemopreventive agent for CRC.
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PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma,PPARdelta and proteasome-independent mechanism,resulting in cell cycle arrest,apoptosis and reduced metas tasis of colorectal carcinoma cells
PPARγ抑制剂通过PPARγ、PPARδ和蛋白酶体独立机制降低微管蛋白水平,导致结直肠癌细胞的细胞周期阻滞、凋亡和转移减少
DOI:
--
发表时间:
2007
期刊:
Int J Cancer 120(3)
影响因子:
--
作者:
[Schaefer KL, Takahashi H, Morales VM, Harris G, Barton S, Osawa E, Nakajima A, Saubermann LJ]
通讯作者:
Saubermann LJ
DOI:
10.1096/fj.06-5809com
发表时间:
2006-09-01
期刊:
FASEB JOURNAL
影响因子:
4.8
作者:
[Wada, Koichiro, Arita, Makoto, Serhan, Charles N.]
通讯作者:
Serhan, Charles N.
Pleural Effusions following Endoscopic Injection Sclerotherapy for Cirrhotic Patients with Exonhageal Varices
肝硬化外胃静脉曲张患者内镜注射硬化剂治疗后胸腔积液
DOI:
--
发表时间:
2006
期刊:
Hepato-Gastroenterology 53
影响因子:
--
作者:
[Hideyuki, Kayama, Masahiko, Inamori, Jun-ichi, Togawa, Takeshi, Shimamura, Yoko, Tokita, Tadashi, Umezawa, Takashi, Sakaguchi, Makoto, Naitoh, ajime, Nagase, Atsushi, Nakajima, Toshifumi, Saito, Shizuo, Tominaga, Norio, Ueno, Katsuaki, Tanaka, Hisahiko, S]
通讯作者:
S
Visceral fat obesity increase dvsnlastic aberrant crint foci
内脏脂肪肥胖增加弹性异常脑病灶
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Takahashi, H., Fujisawa, T., Yonemitsu, K., Tomimoto, A., Endo, H., Nakajima, A]
通讯作者:
A
脂肪性肝疾患の診断方法、診断装置、診断プログラム、診断薬及び脂肪性肝疾患用治療薬のスクリーニング方法
脂肪性肝病的诊断方法、诊断装置、诊断程序、诊断剂以及脂肪性肝病治疗剂的筛选方法
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 34 条
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Nanoscale Designing of Iron-Sulfur Active Center in Nitrogenase towards Nano-biomimetic Enzyme
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The role of PPAR γ in Gastrointestinal disease
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依托单位:
Creation of New Organometallic Cluster and Reaction Dynamics
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依托单位:
Hopf algebra smash product and Quantum Weyl algebra
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