Analysis of Inducers of Transformation From Monocytes to Macrophages and Their Application for vascular Protection Therapy

目的：主动脉脉搏波传导速度（PWV）和炎症标志物如超敏C反应蛋白（hs-CRP）和白细胞介素-6（IL-6）是评价动脉粥样硬化进展的无创性方法。在这项研究中，我们研究是否PWV和炎症标志物之间的健康individuals.Methods：一百零九个明显健康的人谁申请健康咨询在吉冈镇被列入。测量PWV、炎症标志物和总胆固醇水平。结果：PWV与炎症标志物呈正相关。IL-6阳性率高于hs-CRP阳性率。PWV > 13.7m/sec者IL-6值显著增高。结论：即使在健康人中，炎症也是主动脉僵硬的主要因素之一。在炎症标志物中，IL-6可能是动脉粥样硬化的早期预测标志物之一。

Objectives : Aortic pulse wave velocity (PWV) and inflammatory markers, such as high sensitive CRP (hs-CRP) and interleukin-6 (IL-6) are non-invasive approach to evaluate progression of atherosclerosis. In this study, we examined whether PWV and inflammatory markers are correlated among healthy individuals.Methods : One hundred and nine apparently healthy individuals who applied for health counseling in Yoshioka-town were included. PWV, inflammatory markers and total cholesterol levels were measured. The correlation between PWV and inflammatory markers were statistically analyzed by using Statview.Results : We demonstrated the positive correlation between PWV and inflammatory markers. Coefficient rate were higher in IL-6 than that in hs-CRP. The individuals whom PWV were higher than 13.7 m/sec showed significant higher numeric value in IL-6.Conclusion : Even in the healthy individuals, inflammation is thought to be one of the major factors of aortic stiffness. Among the inflammatory markers, IL-6 might be one of the early predictable markers of atherosclerosis.