Role of Renin-Angiotensin system in the development of ischemic mitral regurgitation

肾素-血管紧张素系统在缺血性二尖瓣反流发生中的作用

• 批准号: 15590760
• 负责人: OTSUJI Yutaka
• 金额: $ 2.18万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590760/
• 关键词: ischemic mitral regurgitation; Renin angiotensin; remodeling; congestive heart failure; Ischemic mitral regurgitation; Ischemic; regurgitation; mitral

Ischemic mitral regurgitation (MR) is an independent factor to worsen patients prognosis after the development of acute myocardial infarction. Outward displacement of papillary muscles due to left ventricular remodeling is the main cause of the ischemic MR. Renin-Angiotensin system (RAS) plays a central role in the genesis of left ventricular remodeling following myocardial infarction. Therefore, activation of RAS system may play an essential role in the genesis of ischemic MR, however, the role of RAS on the development of ischemic MR remains uninvestigated.We hypothesized that development of ischemic MR can be attenuated by the absence of RAS activation due to gene abnormality. We produced acute myocardial infarction (AMI) with a similar size by ligation of left anterior descending artery in wild mouse as well as in Angiotensin II type 1A knocked out mouse. The LV dilatation was significantly greater in the wild compared to knocked out mouse. Ischemic MR was observed only in wild mouse (p<0.05). These suggest that RAS plays a central role in the genesis of ischemic MR after the development of AMI.

缺血性二尖瓣反流（MR）是急性心肌梗死后患者预后恶化的独立因素。左心室重构引起的乳头状肌向外移位是缺血性mr的主要原因。肾素-血管紧张素系统（RAS）在心肌梗死后左心室重构的发生中起核心作用。因此，RAS系统的激活可能在缺血性MR的发生中起重要作用，但RAS在缺血性MR发生中的作用尚不清楚。我们假设，由于基因异常导致RAS激活缺失，缺血性MR的发展可能会减弱。我们在野生小鼠和1A型血管紧张素II敲除小鼠中通过结扎左前降支产生了类似大小的急性心肌梗死（AMI）。与敲除小鼠相比，野生小鼠左室扩张明显更大。仅野生小鼠出现缺血MR （p<0.05）。这些提示RAS在AMI发生后缺血性MR的发生中起核心作用。

项目成果

Left Ventricular Remodeling is Less While Left Atrial Remodeling is Greater in Inferior Compared to Anterior Myocardial Infarction

与前壁心肌梗死相比，下壁心肌梗死的左心室重构较少，而左心房重构较大

• 发表时间: 2004
• 期刊: Journal of Echocardiography 2
• 作者: Arikawa K;Otsuji Y;et al.
• 通讯作者: et al.

Relation of aneurysmectomy in patients with advanced left ventricular remodeling to postoperative left ventricular filling pressure, redilatation with ischemic mitral regurgitation.

• DOI: 10.1016/j.amjcard.2004.10.024
• 发表时间: 2005-02
• 期刊: The American journal of cardiology
• 作者: Y. Otsuji;Eiji Kuwahara;K. Yuge;G. Yotsumoto;T. Ueno;Kenichi Nakashiki;S. Hamasaki;S. Biro

Mechanism of persistent ischemic mitral regurgitation after annnuloplasty : importance of augmented posterior mitral leaflet tetheing.

瓣环成形术后持续缺血性二尖瓣反流的机制：增强二尖瓣后叶栓系的重要性。

• 发表时间: 2005
• 期刊: Circulation 112(Suppl I)
• 作者: Zhu F;Otsuji Y. et al.
• 通讯作者: Otsuji Y. et al.

Relation of Aneurysmectomy in Patients with Advanced Left Ventricular Remodeling to Postoperative Left Ventricular Filling Pressure.

晚期左心室重构患者的动脉瘤切除术与术后左心室充盈压的关系。

• 发表时间: 2005
• 期刊: American Journal of Cardiology 95
• 作者: Otsuji Y;et al.
• 通讯作者: et al.

Mechanism of persistent ischemic mitral regurgitation after annuloplasty : importance of augmented posterior mitral leaflet tethering.

瓣环成形术后持续缺血性二尖瓣反流的机制：增强二尖瓣后叶栓系的重要性。

• 发表时间: 2005
• 期刊: Circulation 112(suppl 1)
• 作者: Zhu F;Otsuji Y;Yotsumoto G;Yuasa T;Ueno T;Yu B;Koriyama C;Hamasaki S;Biro S;Kisanuki A;Minagoe S;Levine RA;Sakata R;Tei C
• 通讯作者: Tei C