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Prevenstion of aspiration pneumonia and Research of the clinical application by VR1 and CMR1 agonists.

VR1、CMR1激动剂吸入性肺炎的预防及临床应用研究。

基本信息

批准号：
15590795
负责人：
EBIHARA Satoru
金额：
$ 2.3万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590795/
关键词：
capsaicin TRPV1 troche pneumonia 温度 CMR1 嚥下反射咳反射口腔ケアテオフィリン

项目摘要

Recurrent pneumonia in older people is due to silent aspiration caused by depressed swallowing and cough reflexes because of an insufficient release of substance P.Direct administration of capsaicin to the pharynx can improve the swallowing reflex in older people. However, whether the daily capsaicin supplementation affects those risk factors for recurrent aspiration bronchitis and pneumonia in older people has not been investigated. To determine whether oral capsaicin troche supplementation every meal upregulates the impairment of upper respiratory protective reflexes such as the swallowing reflex and the cough reflex. Randomized-controlled study with recruitment through nursing homes in Sendai, Japan from September 2002 to December 2003. Sixty-four participants in nursing homes aged mean 81.9 ± 1.0 year old with chronic physical status. Participants were randomly assigned to the program for the supplementation of capsaicin trochisci or placebo trochisci soon before every meal for 4 w … More eeks. Assessment of individual latency of the swallowing reflex (LTSR) and cough reflex sensitivity. Before the commencement of this study, there were no significant baseline differences in multiple parameters between the intervention group and control group. LTSR in participants in the intervention group was significantly shortened, compared with the control group (P<.05). The odds ratio (OR) of the shortening of the LTSR of more than 1 minute in the intervention group was 3.4 [95% confidence interval (CI), 1.1-10.4], compared with the control group (P=.03). Particularly, daily capsaicin supplementation significantly increased the ratio of LTSR reduction at 4 weeks after the study to baseline LTSR in the high risk group (baseline LTSR>6.0sec) compared with the low risk group (baseline LTSR<3.0sec) and the intermediate group (3.0sec<baseline LTSR<6.0sec)(P<.005). The participants whose cough reflex sensitivity showed a decrease of the cough reflex threshold was observed in 17 participants (52.1%) in the intervention group but in only 7 participants (21.9%) in the control group after this study (OR : 4.1, [95% CI : 1.4-12.2], P<.01). Daily capsaicin supplementation showed a significant improvement in upper protective respiratory reflexes, particularly in older people with a high risk for aspiration. Less

老年人反复肺炎是由于P物质释放不足导致吞咽抑制和咳嗽反射引起的无声误吸所致。直接将辣椒素滴入咽部可改善老年人的吞咽反射。然而，每日补充辣椒素是否会影响老年人复发性吸入性支气管炎和肺炎的危险因素尚未得到研究。确定每餐补充口服辣椒素锭剂是否会上调上呼吸道保护性反射（例如吞咽反射和咳嗽反射）的损伤。 2002 年 9 月至 2003 年 12 月在日本仙台的疗养院进行的随机对照研究。疗养院的 64 名参与者平均年龄为 81.9 ± 1.0 岁，患有慢性身体状况。参与者被随机分配到每餐前补充辣椒素 trochisci 或安慰剂 trochisci 的项目，持续 4 周。评估个体吞咽反射潜伏期（LTSR）和咳嗽反射敏感性。在本研究开始之前，干预组和对照组之间的多个参数没有显着的基线差异。与对照组相比，干预组参与者的 LTSR 显着缩短 (P<.05)。与对照组相比，干预组 LTSR 缩短超过 1 分钟的优势比 (OR) 为 3.4 [95% 置信区间 (CI)，1.1-10.4] (P=.03)。特别是，与低风险组（基线LTSR<3.0秒）和中间组（3.0秒<基线LTSR<6.0秒）相比，每日补充辣椒素显着增加了高风险组（基线LTSR>6.0秒）在研究后4周时LTSR与基线LTSR降低的比率（P<.005）。在本研究后，干预组中有 17 名参与者（52.1%）观察到咳嗽反射敏感性显示咳嗽反射阈值下降，但对照组只有 7 名参与者（21.9%）（OR：4.1，[95% CI：1.4-12.2]，P <.01）。每日补充辣椒素可显着改善上保护性呼吸反射，特别是对于误吸风险较高的老年人。较少的