Prevenstion of aspiration pneumonia and Research of the clinical application by VR1 and CMR1 agonists.

VR1、CMR1激动剂吸入性肺炎的预防及临床应用研究。

基本信息

批准号：
15590795
负责人：
EBIHARA Satoru
金额：
$ 2.3万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590795/
关键词：
capsaicin TRPV1 troche pneumonia 温度 CMR1 嚥下反射咳反射口腔ケアテオフィリン

项目摘要

Recurrent pneumonia in older people is due to silent aspiration caused by depressed swallowing and cough reflexes because of an insufficient release of substance P.Direct administration of capsaicin to the pharynx can improve the swallowing reflex in older people. However, whether the daily capsaicin supplementation affects those risk factors for recurrent aspiration bronchitis and pneumonia in older people has not been investigated. To determine whether oral capsaicin troche supplementation every meal upregulates the impairment of upper respiratory protective reflexes such as the swallowing reflex and the cough reflex. Randomized-controlled study with recruitment through nursing homes in Sendai, Japan from September 2002 to December 2003. Sixty-four participants in nursing homes aged mean 81.9 ± 1.0 year old with chronic physical status. Participants were randomly assigned to the program for the supplementation of capsaicin trochisci or placebo trochisci soon before every meal for 4 w … More eeks. Assessment of individual latency of the swallowing reflex (LTSR) and cough reflex sensitivity. Before the commencement of this study, there were no significant baseline differences in multiple parameters between the intervention group and control group. LTSR in participants in the intervention group was significantly shortened, compared with the control group (P<.05). The odds ratio (OR) of the shortening of the LTSR of more than 1 minute in the intervention group was 3.4 [95% confidence interval (CI), 1.1-10.4], compared with the control group (P=.03). Particularly, daily capsaicin supplementation significantly increased the ratio of LTSR reduction at 4 weeks after the study to baseline LTSR in the high risk group (baseline LTSR>6.0sec) compared with the low risk group (baseline LTSR<3.0sec) and the intermediate group (3.0sec<baseline LTSR<6.0sec)(P<.005). The participants whose cough reflex sensitivity showed a decrease of the cough reflex threshold was observed in 17 participants (52.1%) in the intervention group but in only 7 participants (21.9%) in the control group after this study (OR : 4.1, [95% CI : 1.4-12.2], P<.01). Daily capsaicin supplementation showed a significant improvement in upper protective respiratory reflexes, particularly in older people with a high risk for aspiration. Less

老年人的复发性肺炎是由于吞咽抑郁症引起的无声抽吸和咳嗽反射引起的，由于咽中辣椒素对咽部的释放不足可以改善老年人的吞咽反射。但是，尚未研究每日辣椒素补充剂会影响老年人复发性抽吸支气管炎和肺炎的危险因素。为了确定是否补充口服辣椒素的辣椒蛋白是否会增加上呼吸道保护反射的损害，例如吞咽反射和咳嗽反射。从2002年9月至2003年12月，通过日本仙台的疗养院进行招聘的随机控制研究。六十四名参与者的疗养院年龄为81.9±1.0岁，具有长期的身体状况。参与者被随机分配到该计划中，以补充辣椒素trochisci或安慰剂trochisci在每顿饭前不久，要花4 W…更多。评估吞咽反射（LTSR）和咳嗽反射灵敏度的个体潜伏期。在本研究开始之前，干预组和对照组之间的多个参数没有显着的基线差异。与对照组相比，干预组参与者的LTSR显着缩短（p <.05）。与对照组相比，干预组中LTSR超过1分钟的LTSR缩短的几率（OR）为3.4 [95％置信区间（CI），1.1-10.4]（p = .03）。特别是，与低风险组（基线LTSR LTSR <3.0 -SEC）相比，研究后4周（基线LTSR> 6.0秒）在研究后4周（基线LTSR> 6.0秒）的LTSR降低的比率显着增加了LTSR降低的比率（3.0Sec <3.0sec <6.0secr LTSR <6.0SEC）（p <6.0SEC）（p <6.0SEC）（p <3.055）。咳嗽反射敏感性的参与者在干预组的17名参与者（52.1％）中观察到咳嗽反射阈值的降低，但在本研究之后，对照组中只有7名参与者（21.9％）（OR：4.1，[95％CI：1.4-12.2]，p <.01）。每日补充辣椒素的呼吸反射表现出显着改善，尤其是在具有高吸入风险的老年人中。较少的