Mechanism of sensory dysfunction of swallowing in elderly people and its applied regenerative therapy

我们发现老年人吞咽困难的主要原因是热感TRP通道功能障碍。为了再生热感TRP通道的功能，我们开发了使用capcapate（无刺激性TRPV1激动剂）和红酒多酚（TRPV1调节剂）来再生TRPV1反应的方法。通过结合再生热感TRP通道的方法，我们制定了一项方案，使吸入性肺炎禁食患者更有效、更安全地开始进食。使用该方案，肺炎的发病率和从口服开始1个月内的发热天数显著减少。

We found that dysphagia in elderly is mainly due to dysfunction of thermosensing TRP channels. In order to regenerate the function of thermosensing TRP channels, we developed methods to regenerate TRPV1 response using capsiate, non-pungent TRPV1 agonist, and red wine polyphenols, a TRPV1 modulator. By combining methods to regenerate thermosensing TRP channels, we developed a protocol to start eating more efficiently and safely in fasted patients with aspiration pneumonia. Using this protocol, the incidence of pneumonia and the number of febrile days for 1 mont h from the start of oral intake were significantly reduced.