Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver

点击翻译按钮获取中文摘要

It is thought that many case of encephalitis after infection of influenza virus are associated with the defect of β-oxidation. However, the mechanism remain unclear. Because juvenile visceral steatosis(JVS)mouse has a defective OCTN-2(carnitine transporter), the β-oxidation is suppressed in the cell. Therefore, after infection of influenza virus, JVS mouse is supposed to be suffered from encephalitis at high frequency. So, first of all, we analyzed the characteristics of JVS mouse.1.Mechanism of death in weaning periodAbout 90% of new born JVS mouse die in weaning period. It has been reported that serum level of ammonia is high in JVS mouse in comparison with normal control. However, the level was a little higher than the normal control. In contract to it, serum level of glucose was low.JVS mouse given high carnitine diet can escape the death and hypoglycemia. These mechanism remains still unknown.2.Analysis of up-and down-regulation genesWe found several interesting molecular aspects that have not yet been identified in the hearts of JVS mice, including down-regulation of a number of ion channels and up-regulators involved in cell cycle progression.