A comprehensive study of the regulatory mechanisms for prognosis-related leukaemia cell surface antigen expression
预后相关白血病细胞表面抗原表达调控机制的综合研究
基本信息
- 批准号:15591040
- 负责人:
- 金额:$ 2.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Using a CD7-expressing human acute myeloblasticleukaemia (AML) cell line, KG-1a, and its parentalline lacking CD7 expression, KG-1, we examined the CD7 gene structure and the levels in mRNA and protein expression, by cytogenetic observation, genomic PCR-direct sequencing, quantitative RT-PCR and flowcytometry. These analyses revealed that CD7 expression in KG-1a cells is 260-times higher than in KG -1 cells and is regulated at the mRNA level. To address further the regulatory mechanisms of CD7 expression, analyses on the transcription frequency or the mRNA stability are needed.
本研究采用细胞遗传学观察、基因组PCR直接测序、定量RT-PCR和流式细胞术等方法,对表达CD 7的人急性成髓细胞白血病(AML)细胞系KG-1a及其亲本细胞系KG-1的CD 7基因结构、mRNA和蛋白表达水平进行了研究。这些分析表明,KG-1a细胞中的CD 7表达比KG-1细胞高260倍,并且在mRNA水平上受到调节。为了进一步阐明CD 7表达的调控机制,需要对转录频率或mRNA稳定性进行分析。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Suminoe A et al.: "mRNA expression of apoptosis-associated genes in infant acute lymphoblastic leukemia : low Fas expression is an independent predictor for poor prognosis"Leukemia. 18. 365-368 (2004)
Suminoe A 等人:“婴儿急性淋巴细胞白血病中凋亡相关基因的 mRNA 表达:低 Fas 表达是不良预后的独立预测因子”白血病。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takagi M et al.: "Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease"Blood. 103. 283-290 (2004)
Takagi M 等人:“儿童霍奇金病中共济失调毛细血管扩张突变 (ATM) 基因多态性变异的鉴定和表征”血液。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Prognostic factors for relapsed childhood acute lymphoblastic leukemia: Impact of allogeneic stem cell transplantation-a report from the Kyushu-Yamaguchi Children's Cancer Study Group.
复发性儿童急性淋巴细胞白血病的预后因素:同种异体干细胞移植的影响——九州山口儿童癌症研究组的报告。
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Matsuzaki;A. et al.
- 通讯作者:A. et al.
Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma
- DOI:10.1182/blood-2004-11-4193
- 发表时间:2005-05-15
- 期刊:
- 影响因子:20.3
- 作者:Okamura, J;Utsunomiya, A;Saburi, Y
- 通讯作者:Saburi, Y
Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.
人类癌症中微卫星不稳定性的两种模式:有缺陷的DNA不匹配修复与二核苷酸重复不稳定性的差异连接。
- DOI:10.1093/nar/gki303
- 发表时间:2005
- 期刊:
- 影响因子:14.9
- 作者:Oda, S;Maehara, Y;Ikeda, Y;Oki, E;Egashira, A;Okamura, Y;Takahashi, I;Kakeji, Y;Sumiyoshi, Y;Miyashita, K;Yamada, Y;Zhao, Y;Hattori, H;Taguchi, K;Ikeuchi, T;Tsuzuki, T;Sekiguchi, M;Karran, P;Yoshida, MA
- 通讯作者:Yoshida, MA
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OKAMURA Jun其他文献
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{{ truncateString('OKAMURA Jun', 18)}}的其他基金
DNA mismatch repair deficiency in paediatric haematological malignancies: research and application for chemotherapeutic strategies
儿科血液恶性肿瘤DNA错配修复缺陷:化疗策略的研究与应用
- 批准号:
22591173 - 财政年份:2010
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular mechanisms of the antineoplastic agents inhibiting DNA replication and their applications to cancer patient treatmen
抗肿瘤药物抑制DNA复制的分子机制及其在癌症患者治疗中的应用
- 批准号:
19591274 - 财政年份:2007
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of biomarkers to predict anticancer drug sensitivities by means of transgene experiments
通过转基因实验鉴定生物标志物以预测抗癌药物敏感性
- 批准号:
17591136 - 财政年份:2005
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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