Noninvasive optical imaging in the sensorimotor cortex in newborn infants.

新生儿感觉运动皮层的无创光学成像。

• 批准号: 15591159
• 负责人: KUSAKA Takashi
• 金额: $ 2.3万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591159/
• 关键词: Infant; Functional imaging; Optical imaging; Passive movement; Sensorimotor cortex; Near-infrared spectroscopy; Multi-channel; Topography

Multi-channel near-infrared spectroscopy (NIRS) was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in concentration of oxyhemoglobin [oxyHb] and total hemoglobin [totalHb] from the baseline values at locations in the sensorimotor area of all infants. During ipsilateral knee and elbow movement, [oxyHb] showed slighter changes, equivalent to 64±23 % and 66±28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 sec for contralateral knee stimulus, 17.9±5.7 sec for contralateral elbow stimulus, respectively. The mean time corresponding to maximal changes in [oxyHb] were not statistically significant between during contralateral and ipsilateral knee stimulus or elbow stimulus.This study has shown that sensorimotor area function in response to passive motor stimulation of the knee and elbow joint can be imaged and evaluated even in newborn infants during sleep under sedation. Data obtained by multi-channel NIRS should be useful for understanding the pathophysiology of the developing regional brain and the brain's response to damage in various clinical situations.

采用多通道近红外光谱（NIRS）技术，对新生儿在镇静睡眠状态下被动膝关节和肘关节运动时感觉运动皮层进行功能成像。在所有婴儿的感觉运动区，外侧膝关节和肘关节运动导致氧合血红蛋白[oxyHb]和总血红蛋白[totalHb]浓度较基线值显著增加。在同侧膝关节和肘关节运动期间，[oxyHb]显示出轻微的变化，分别相当于对侧刺激发生的变化的64± 23%和66±28%。对应于[oxyHb]最大变化的平均时间分别为对侧膝关节刺激的16.1 ± 3.3秒和对侧肘关节刺激的17.9±5.7秒。[oxyHb]的最大变化对应的平均时间在对侧和同侧膝关节刺激或肘stimulation.This研究表明，感觉运动区功能的被动运动刺激的膝关节和肘关节之间没有统计学意义，可以成像和评估，即使在新生儿在睡眠期间镇静。通过多通道近红外光谱获得的数据应该是有用的了解发育中的区域大脑的病理生理和大脑的反应，在各种临床情况下的损害。

项目成果

Eiji Yamada, Takashi Kusaka, et al.: "Relationships of muscle oxygenation with muscle force and electromyography during isometric contraction."Isokinetics and Exercise Science. 11. 213-218 (2003)

Eiji Yamada、Takashi Kusaka 等人：“等长收缩期间肌肉氧合与肌肉力量和肌电图的关系。”等速学和运动科学。

Vastus lateralis oxygenation and blood volume measured by near‐infrared spectroscopy during whole body vibration

• DOI: 10.1111/j.1475-097x.2005.00614.x
• 发表时间: 2005-07
• 期刊: Clinical Physiology and Functional Imaging
• 影响因子: 1.8
• 作者: E. Yamada;T. Kusaka;K. Miyamoto;Satoshi Tanaka;S. Morita;Shouichi Tanaka;S. Tsuji;S. Mori;H. Norimatsu;S. Itoh

Takashi Kusaka, Kou Kawada, et al.: "Noninvasive optical imaging in the visual cortex in young infants"Human Brain Mapping. 22. 122-132 (2004)

Takashi Kusaka、Kou Kawada 等人：“幼儿视觉皮层的非侵入性光学成像”人脑绘图。

Estimation of circulating blood volume in infants using the pulse dye densitometry method.

使用脉冲染料密度测定法估计婴儿循环血量。

• 发表时间: 2005
• 期刊: Paediatric Anaesthesia 15
• 作者: Nagano K;Kusaka T;Okubo K;et al.
• 通讯作者: et al.

Kusaka Takashi, Okubo Kensuke, et al.: "Activation of the visual cortex in newborn infants under natural sleep using multichannel near-infrared spectroscopy."Adv.Ex.p Med.Biol.. 510. 255-259 (2003)

Kusaka Takashi、Okubo Kensuke 等人：“使用多通道近红外光谱激活自然睡眠下新生儿的视觉皮层。”Adv.Ex.p Med.Biol.. 510. 255-259 (2003)