Noninvasive optical imaging in the sensorimotor cortex in newborn infants.

新生儿感觉运动皮层的无创光学成像。

• 批准号: 15591159
• 负责人: KUSAKA Takashi
• 金额: $ 2.3万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591159/
• 关键词: Infant; Functional imaging; Optical imaging; Passive movement; Sensorimotor cortex; Near-infrared spectroscopy; Multi-channel; Topography

Multi-channel near-infrared spectroscopy (NIRS) was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in concentration of oxyhemoglobin [oxyHb] and total hemoglobin [totalHb] from the baseline values at locations in the sensorimotor area of all infants. During ipsilateral knee and elbow movement, [oxyHb] showed slighter changes, equivalent to 64±23 % and 66±28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 sec for contralateral knee stimulus, 17.9±5.7 sec for contralateral elbow stimulus, respectively. The mean time corresponding to maximal changes in [oxyHb] were not statistically significant between during contralateral and ipsilateral knee stimulus or elbow stimulus.This study has shown that sensorimotor area function in response to passive motor stimulation of the knee and elbow joint can be imaged and evaluated even in newborn infants during sleep under sedation. Data obtained by multi-channel NIRS should be useful for understanding the pathophysiology of the developing regional brain and the brain's response to damage in various clinical situations.

多通道近红外光谱法（NIR）用于在镇静睡眠下被动膝盖和肘部运动期间新生婴儿的感觉运动皮层的功能成像。对侧膝盖和肘部运动引起了所有婴儿的感觉运动区域的基线值的氧气血红蛋白[OxyHb]和总血红蛋白[TotalHB]显着增加。在同侧膝盖和肘部运动过程中，[OxyHb]显示出略有变化，相当于分别为对侧刺激发生的变化的64±23％和66±28％。对侧膝关节刺激的[oxyHb]最大变化的平均时间分别为16.1±3.3秒，对侧肘部刺激分别为17.9±5.7 sec。在对侧和同侧膝盖刺激或肘部刺激过程中，[oxyHb]最大变化的平均时间在统计学上没有统计学意义。这项研究表明，在睡眠不足过程中，即使在睡眠不足的婴儿中，感觉运动区域响应膝关节和肘关节的被动运动刺激的响应，即使在新生儿的婴儿中，也可以对膝关节和肘关节进行评估。多通道NIR获得的数据对于理解发展中大脑的病理生理以及大脑对各种临床情况损伤的反应应该很有用。

项目成果

Eiji Yamada, Takashi Kusaka, et al.: "Relationships of muscle oxygenation with muscle force and electromyography during isometric contraction."Isokinetics and Exercise Science. 11. 213-218 (2003)

Eiji Yamada、Takashi Kusaka 等人：“等长收缩期间肌肉氧合与肌肉力量和肌电图的关系。”等速学和运动科学。

Takashi Kusaka, Kou Kawada, et al.: "Noninvasive optical imaging in the visual cortex in young infants"Human Brain Mapping. 22. 122-132 (2004)

Takashi Kusaka、Kou Kawada 等人：“幼儿视觉皮层的非侵入性光学成像”人脑绘图。

Cerebral distribution of cardiac output in infants.

婴儿心输出量的大脑分布。

• 发表时间: 2005
• 期刊: Arch Dis Child Fetal Neonatal Ed 90
• 作者: Kusaka T;Okubo K;Nagano K;et al.
• 通讯作者: et al.

Kusaka Takashi, Okubo Kensuke, et al.: "Activation of the visual cortex in newborn infants under natural sleep using multichannel near-infrared spectroscopy."Adv.Ex.p Med.Biol.. 510. 255-259 (2003)

Kusaka Takashi、Okubo Kensuke 等人：“使用多通道近红外光谱激活自然睡眠下新生儿的视觉皮层。”Adv.Ex.p Med.Biol.. 510. 255-259 (2003)

Estimation of circulating blood volume in infants using the pulse dye densitometry method.

使用脉冲染料密度测定法估计婴儿循环血量。

• 发表时间: 2005
• 期刊: Paediatric Anaesthesia 15
• 作者: Nagano K;Kusaka T;Okubo K;et al.
• 通讯作者: et al.