Noninvasive optical imaging in the sensorimotor cortex in newborn infants.

使用多通道近红外光谱（NIRS）对新生儿在镇静睡眠下被动膝盖和肘部运动期间的感觉运动皮质进行功能成像。在所有婴儿的感觉运动区，外侧膝关节和肘关节运动导致氧合血红蛋白[oxyHb]和总血红蛋白[totalHb]浓度较基线值显著增加。在同侧膝关节和肘关节运动期间，[oxyHb]显示出轻微的变化，分别相当于对侧刺激发生的变化的64± 23%和66±28%。对应于[oxyHb]最大变化的平均时间分别为对侧膝关节刺激的16.1 ± 3.3秒和对侧肘关节刺激的17.9±5.7秒。[oxyHb]的最大变化对应的平均时间在对侧和同侧膝关节刺激或肘stimulation.This研究表明，感觉运动区功能的被动运动刺激的膝关节和肘关节之间没有统计学意义，可以成像和评估，即使在新生儿在睡眠期间镇静。通过多通道近红外光谱获得的数据应该是有用的了解发育中的区域大脑的病理生理和大脑的反应，在各种临床情况下的损害。

Multi-channel near-infrared spectroscopy (NIRS) was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in concentration of oxyhemoglobin [oxyHb] and total hemoglobin [totalHb] from the baseline values at locations in the sensorimotor area of all infants. During ipsilateral knee and elbow movement, [oxyHb] showed slighter changes, equivalent to 64±23 % and 66±28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 sec for contralateral knee stimulus, 17.9±5.7 sec for contralateral elbow stimulus, respectively. The mean time corresponding to maximal changes in [oxyHb] were not statistically significant between during contralateral and ipsilateral knee stimulus or elbow stimulus.This study has shown that sensorimotor area function in response to passive motor stimulation of the knee and elbow joint can be imaged and evaluated even in newborn infants during sleep under sedation. Data obtained by multi-channel NIRS should be useful for understanding the pathophysiology of the developing regional brain and the brain's response to damage in various clinical situations.