New optical brain imaging in infants by using near-infrared diffuse optical tomography

使用近红外漫射光学断层扫描对婴儿进行新的光学脑成像

基本信息

  • 批准号:
    17390307
  • 负责人:
  • 金额:
    $ 5.82万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2006
  • 项目状态:
    已结题

项目摘要

An optical 3D imaging method using near-infrared diffuse optical tomography (NIR DOT) to estimate the regional light scattering and absorption properties in infants has been developed. The NIR DOT system is consisted of 16 source-detector fibers, pulsed diode lasers operating at the wavelengths of 759 and 835 nm and time correlated single photon counting units. The image reconstruction algorithm is based on the modified generalized pulsed spectral technique. The time-resolved data were used to estimate for concentration of oxyHb and deoxyHb.DOT was measured in an infant on 29 days after birth, whose gestational age and birth weight was 23 weeks and 658g, assisted by an artificial respirator. Informed consent in writing was obtained from the parents, and the study was approved by the local ethics committee.The data under two different state, (A) normocapnea and (B) hypocapnea induced by hyperventilation, were obtained. DOT images showed the Hb concentrations obtained at the state (B) subtracted by (A). The results showed that the total Hb concentration in the most parts of the brain decreased, reflecting the decrease in cerebral blood flow, especially white matter regions. The results demonstrated that NIR DOT is capable of reconstructing the images of Hb concentration with a high spatial resolution in infants at the bedside.
提出了一种利用近红外漫射光学层析成像(NIR DOT)估计婴儿区域光散射和吸收特性的光学三维成像方法。近红外DOT系统由16根源探测器光纤、759和835 nm波长的脉冲二极管激光器和时间相关单光子计数单元组成。图像重建算法基于改进的广义脉冲光谱技术。时间分辨数据用于估计氧血红蛋白和脱氧血红蛋白的浓度。在人工呼吸辅助下,于出生后29天测量胎龄23周、出生体重658g的婴儿DOT。获得了父母的书面知情同意,研究得到了当地伦理委员会的批准。获得两种不同状态下的数据,(A)正常呼吸和(B)过度通气导致的低呼吸。DOT图像显示(B)减去(A)状态下获得的Hb浓度。结果显示,大鼠大脑大部分区域总Hb浓度下降,反映出脑血流量减少,尤其是脑白质区域。结果表明,近红外DOT能够以高空间分辨率重建婴儿床边的Hb浓度图像。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Functional optical hemodynamic imaging of the olfactory cortex
  • DOI:
    10.1097/mlg.0b013e31802ffe2a
  • 发表时间:
    2007-03-01
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Kobayashi, Eiji;Kusaka, Takashi;Mori, Nozomu
  • 通讯作者:
    Mori, Nozomu
In vitro production of bilirubin photaisomers by light ircadiation using neoBLUE.
使用 neoBLUE 通过光照射体外生产胆红素光异构体。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Okada H;Abe T;Etoh Y;Yosbino S;Kate I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;Nemba M;Nisbitla T;Imai T;Isobe K;Itoh S.
  • 通讯作者:
    Itoh S.
In vitro production of bilirubin photoisomers by light irradiation using neoBLUE
使用 neoBLUE 通过光照射体外生产胆红素光异构体
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Okada H;Abe T;Etoh Y;Yoshino S;Kato I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;et. al.
  • 通讯作者:
    et. al.
Accumulation of triosephosphate isomerass, with sequence homology to amyloid peptides, in vessel walls of the newborn piglet hippocampue.
与淀粉样肽序列同源的磷酸三糖异构体在新生仔猪海马体的血管壁中积累。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kusaka T;Ueno M;Mulci T;Kanenishi K;Nagai Y;Huang CL;Okamoto Y;Ogawa T;Onodera hi;Itoh S;Altiguchi I;Sakamoto H.
  • 通讯作者:
    Sakamoto H.
Accumulation of triosephosphate isomerase, with sequence homology to ・amyloid peptides, in vessel walls of the newborn piglet hippocampus
与淀粉样肽序列同源的磷酸三糖异构酶在新生仔猪海马血管壁中的积累
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kusaka T.;Ueno M.;Miki T.;Huang C.;et.al.
  • 通讯作者:
    et.al.
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KUSAKA Takashi其他文献

Mother-infant Interaction Induces Physiological Reactions in the Brain
母婴互动引起大脑生理反应
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    TANIMOTO Kimie;KATO Ikuko;KUSAKA Takashi;TOKUCHI Nobuko
  • 通讯作者:
    TOKUCHI Nobuko

KUSAKA Takashi的其他文献

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{{ truncateString('KUSAKA Takashi', 18)}}的其他基金

Strategy for hypoxic-ischemic encephalopathy in newborn infants to reduce oxygen free radicals by adjusting hydrogen and oxygen
调整氢氧减少氧自由基治疗新生儿缺氧缺血性脑病的策略
  • 批准号:
    22591201
  • 财政年份:
    2010
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Developmental changes in cerebral oxygen metabolism during neonatal period
新生儿期脑氧代谢的发育变化
  • 批准号:
    19591281
  • 财政年份:
    2007
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Estimation of the temporal and spatial distribution of the optically thin Asian dust from satellite image data
根据卫星图像数据估计光学稀亚洲尘埃的时空分布
  • 批准号:
    16510011
  • 财政年份:
    2004
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Noninvasive optical imaging in the sensorimotor cortex in newborn infants.
新生儿感觉运动皮层的无创光学成像。
  • 批准号:
    15591159
  • 财政年份:
    2003
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The estimation of the advection diffusion and the optical characteristics of the Asian dust using satellite_level data
利用卫星级数据估计亚洲沙尘的平流扩散和光学特性
  • 批准号:
    13680611
  • 财政年份:
    2001
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Evaluation of Yellow Sand Dust in the Vegetation Index Estimated from Satellite-level Data
黄沙尘在卫星级数据估算植被指数中的评价
  • 批准号:
    10680508
  • 财政年份:
    1998
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The development of the hypermedia CAI system on the Internet
互联网超媒体CAI系统的开发
  • 批准号:
    07558146
  • 财政年份:
    1995
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Extraction of Global Environmental Change caused by Human Activities
人类活动引起的全球环境变化的提取
  • 批准号:
    04832042
  • 财政年份:
    1992
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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Naturalistic Brain Mapping in Children with Diffuse Optical Tomography
利用漫射光学断层扫描对儿童进行自然脑图绘制
  • 批准号:
    10720660
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
Asymptotic analysis and its application to fluorescence diffuse optical tomography
渐近分析及其在荧光漫射光学层析成像中的应用
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    23K19002
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    2023
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    $ 5.82万
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Diffuse Optical Tomography for Identifying Early Complicationsof Aneurysmal Subarachnoid Hemorrhage
弥漫性光学断层扫描识别动脉瘤性蛛网膜下腔出血的早期并发症
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    10508982
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    2022
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PFI-TT: Wearable Noninvasive Brain Imaging with Near-Infrared Light Based on Time-Domain Diffuse Optical Tomography
PFI-TT:基于时域漫射光学断层扫描的可穿戴式近红外光无创脑成像
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    2141006
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  • 项目类别:
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Wearable modular high-density diffuse optical tomography
可穿戴式模块化高密度漫射光学断层扫描
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可穿戴式模块化高密度漫射光学断层扫描
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用于动态功能成像的单像素漫反射光学断层扫描仪
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使用具有压缩传感功能的单次光学断层扫描进行极限体积成像
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