New optical brain imaging in infants by using near-infrared diffuse optical tomography

使用近红外漫射光学断层扫描对婴儿进行新的光学脑成像

• 批准号: 17390307
• 负责人: KUSAKA Takashi
• 金额: $ 5.82万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390307/
• 关键词: Near-infrared spectroscopy; Optical tomography; Infant; Hypocapnea; Cerebral blood volume; Periventricular leukomalasia; Time-resolved spectroscopy; Cerebral Hb oxygen saturation; 低出生体重児; 脳内血液量; 脳内ヘモグロビン酸素飽和度; 吸収係数; 散乱係数; トモグラフィー; 新生児; 脳

An optical 3D imaging method using near-infrared diffuse optical tomography (NIR DOT) to estimate the regional light scattering and absorption properties in infants has been developed. The NIR DOT system is consisted of 16 source-detector fibers, pulsed diode lasers operating at the wavelengths of 759 and 835 nm and time correlated single photon counting units. The image reconstruction algorithm is based on the modified generalized pulsed spectral technique. The time-resolved data were used to estimate for concentration of oxyHb and deoxyHb.DOT was measured in an infant on 29 days after birth, whose gestational age and birth weight was 23 weeks and 658g, assisted by an artificial respirator. Informed consent in writing was obtained from the parents, and the study was approved by the local ethics committee.The data under two different state, (A) normocapnea and (B) hypocapnea induced by hyperventilation, were obtained. DOT images showed the Hb concentrations obtained at the state (B) subtracted by (A). The results showed that the total Hb concentration in the most parts of the brain decreased, reflecting the decrease in cerebral blood flow, especially white matter regions. The results demonstrated that NIR DOT is capable of reconstructing the images of Hb concentration with a high spatial resolution in infants at the bedside.

提出了一种利用近红外漫反射光学层析成像技术（NIR DOT）来估计婴儿局部光散射和吸收特性的光学三维成像方法。近红外DOT系统由16个光源-探测器光纤、工作波长为759和835 nm的脉冲二极管激光器和时间相关单光子计数单元组成。图像重建算法是基于改进的广义脉冲光谱技术。应用时间分辨数据估计氧合血红蛋白（oxyHb）和脱氧血红蛋白（deoxyHb）浓度，并对1例胎龄23周、出生体重658 g的新生儿在人工呼吸机辅助下于生后29 d进行DOT测定。获得父母的书面知情同意书，并获得当地伦理委员会的批准，获得了两种不同状态下的数据，（A）正常二氧化碳呼吸和（B）过度通气引起的低二氧化碳呼吸。DOT图像示出了在状态（B）下获得的Hb浓度减去（A）。结果表明，脑大部分区域总血红蛋白浓度降低，反映脑血流量减少，尤其是白色区。结果表明，近红外DOT能够在床边重建具有高空间分辨率的婴儿血红蛋白浓度图像。

项目成果

Functional optical hemodynamic imaging of the olfactory cortex

• DOI: 10.1097/mlg.0b013e31802ffe2a
• 发表时间: 2007-03-01
• 期刊: LARYNGOSCOPE
• 影响因子: 2.6
• 作者: Kobayashi, Eiji;Kusaka, Takashi;Mori, Nozomu
• 通讯作者: Mori, Nozomu

In vitro production of bilirubin photaisomers by light ircadiation using neoBLUE.

使用 neoBLUE 通过光照射体外生产胆红素光异构体。

• 发表时间: 2007
• 期刊: irediatr tnt. 49(3)
• 作者: Okada H;Abe T;Etoh Y;Yosbino S;Kate I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;Nemba M;Nisbitla T;Imai T;Isobe K;Itoh S.
• 通讯作者: Itoh S.

In vitro production of bilirubin photoisomers by light irradiation using neoBLUE

使用 neoBLUE 通过光照射体外生产胆红素光异构体

• 发表时间: 2007
• 期刊: Pediatr Int. Jun;49(3)
• 作者: Okada H;Abe T;Etoh Y;Yoshino S;Kato I;Iwaki T;Okubo K;Yasuda S;Kawada K;Kusaka T;et. al.
• 通讯作者: et. al.

Accumulation of triosephosphate isomerass, with sequence homology to amyloid peptides, in vessel walls of the newborn piglet hippocampue.

与淀粉样肽序列同源的磷酸三糖异构体在新生仔猪海马体的血管壁中积累。

• 发表时间: 2007
• 期刊: Microscopy Research and Technique 70(7)
• 作者: Kusaka T;Ueno M;Mulci T;Kanenishi K;Nagai Y;Huang CL;Okamoto Y;Ogawa T;Onodera hi;Itoh S;Altiguchi I;Sakamoto H.
• 通讯作者: Sakamoto H.

Accumulation of triosephosphate isomerase, with sequence homology to ・amyloid peptides, in vessel walls of the newborn piglet hippocampus

与淀粉样肽序列同源的磷酸三糖异构酶在新生仔猪海马血管壁中的积累

• 发表时间: 2007
• 期刊: Microsc. Res. Techniq 70
• 作者: Kusaka T.;Ueno M.;Miki T.;Huang C.;et.al.
• 通讯作者: et.al.