The study on microglial activation by beta amyloid, peptides of Alzheimer's disease.

β淀粉样蛋白（阿尔茨海默病肽）激活小胶质细胞的研究。

• 批准号: 15591230
• 负责人: MONJI Akira
• 金额: $ 1.79万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591230/
• 关键词: beta amyloid; microglia; Alzheimer; cytokine; free radical; bota-amilaid; microglio; Alzheimer; inflammation; cytokine; free radical; 炎症

There is increasing evidence that inflammatory activation of microglia has pathogenic infuence on Alzheimer's disease(AD). According to in vitro studies, microglia activated by beta amyloid (Abeta) peptides have been reported to damage or kill neurons by the release of neirotoxic molecules such as tumor necrosis factor-alpha(TNF-alfa), nitric oxide, or reactive oxygen species. This study has demonstrated the two following results on microglial activation by the A beta peptides.1.Abeta fbril formation is not necessarily required for microglial activation by the peptides.2.PS(phosphatidylserine)-liposomes can inhibit microglial activation by the Abeta peptides and suppress the generation of TNF-alfa, nitric oxide, and reactive oxygen species from microglia.

越来越多的证据表明，小胶质细胞的炎性激活在阿尔茨海默病（AD）中具有致病作用。根据体外研究，已报道由β淀粉样蛋白（Abeta）肽激活的小胶质细胞通过释放神经毒性分子如肿瘤坏死因子-α（TNF-α）、一氧化氮或活性氧物质来损伤或杀死神经元。本研究证明了以下两个结果对小胶质细胞激活的A β肽。1.Abeta fbril的形成是不一定需要的小胶质细胞激活的肽。2.PS（磷脂酰丝氨酸）-脂质体可以抑制小胶质细胞激活的A β肽和抑制TNF-α，一氧化氮，和活性氧物种从小胶质细胞的产生。

项目成果

Abeta fbril formation is not necessarily required for microglial activation by the peptides.

Abeta原纤维的形成对于肽激活小胶质细胞来说不一定是必需的。

• 发表时间: 2005
• 期刊: Neurochemistry International (in press)
• 作者: Gu;X.;Fujii;S.;Kato;K.;S.Hashioka
• 通讯作者: S.Hashioka

Abeta fibril formation is not necessarily required for microglial activation by the peptides.

Abeta 原纤维的形成不一定是肽激活小胶质细胞所必需的。

• 发表时间: 2005
• 期刊: Neurochemistry International (in press)
• 作者: Kato K et al.;Chu CP et al.;Hashioka S
• 通讯作者: Hashioka S

Monji A, Yoshida I, Hashioka S, Tashiro K: "Laminin and its related peptides on Alzheimer's disease pathology."Current Topics in Peptide & Protein Research. 5. 143-148 (2003)

Monji A、Yoshida I、Hashioka S、Tashiro K：“层粘连蛋白及其相关肽对阿尔茨海默病病理学的影响。”肽当前主题