The study on microglial activation by beta amyloid, peptides of Alzheimer's disease.

点击翻译按钮获取中文摘要

There is increasing evidence that inflammatory activation of microglia has pathogenic infuence on Alzheimer's disease(AD). According to in vitro studies, microglia activated by beta amyloid (Abeta) peptides have been reported to damage or kill neurons by the release of neirotoxic molecules such as tumor necrosis factor-alpha(TNF-alfa), nitric oxide, or reactive oxygen species. This study has demonstrated the two following results on microglial activation by the A beta peptides.1.Abeta fbril formation is not necessarily required for microglial activation by the peptides.2.PS(phosphatidylserine)-liposomes can inhibit microglial activation by the Abeta peptides and suppress the generation of TNF-alfa, nitric oxide, and reactive oxygen species from microglia.