Effect of irradiation of the brain tumor with X-ray and heavy ion on sexual behavior.

X射线和重离子照射脑肿瘤对性行为的影响。

• 批准号: 15591258
• 负责人: UNO Takashi
• 金额: $ 2.24万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591258/
• 关键词: Central nervous system; Heavy iron; Sexual function; Hypothalamus; Copulatory behavior

The effect of heavy-ion irradiation to the brain on sexual behavior is not yet known. The present study was designed to determine whether irradiation (carbon particles,290 MeV/nucleon, Mono peak 15~ 120 Gy,irradiation field 5-mm^3 in hypothalamus) to rat's hypothalamus modifies copulatory behavior of male rats. We planned to estimate the short-term effects of carbon-irradiation on copulatory behavior using a relatively high doses, and observation of sexual behavior was conducted for 30 min after 1,2 or 3 months following irradiation.Results obtained are as follows :1.At dosages of 15Gy,30Gy,45Gy and 60Gy, these were no changes in copulatory behavior after 1 month following irradiation ; however, intromission and ejaculation were found to decrease after 3-month follow-up in rats exposed to 60 Gy.2.At higher doses such as 90Gy,120Gy, the number of mounting, intromission (120Gy alone) and ejaculation (90Gy,120Gy) were decreased.From the experimental results described above, it may be possible to determine that carbon beam irradiation to hypothalamus does not inhibit the activity of copulatory behavior for a short period after irradiation. Further experiments that need long-term follow-up after irradiation must be necessary to determine the chronic effects of heavy ions on the copulatory behavior.

脑部重离子照射对性行为的影响尚不清楚。本研究旨在探讨碳颗粒、290 MeV/核子、Mono峰15~ 120 Gy、下丘脑5 mm^3的照射场对大鼠下丘脑的影响。我们计划使用相对高剂量的碳照射来评估对交配行为的短期影响，并在照射后1个月、2个月和3个月分别进行30分钟的性行为观察。实验结果如下：1。在15Gy、30Gy、45Gy和60Gy剂量下，照射1个月后，这些动物的交配行为没有变化；然而，暴露于60gy的大鼠在3个月的随访后发现射精和射精减少。在较高剂量（如90Gy、120Gy）下，安装、射精（仅120Gy）和射精（90Gy、120Gy）的数量减少。根据上述实验结果，可以确定碳束照射下丘脑在照射后的短时间内不会抑制交配行为的活性。为了确定重离子对交配行为的慢性影响，有必要在辐照后进行长期随访的进一步实验。

项目成果

Radiation-Induced Chromosome Aberrations in Ataxia Telangiectasia Cell Line : high frequency of deletions and misrejoining detected by fluorescence in situ hybridization.

共济失调毛细血管扩张细胞系中辐射诱导的染色体畸变：通过荧光原位杂交检测到高频率的缺失和错误重连。

• 发表时间: 2003
• 期刊: Radiat Res 159(3)
• 作者: Kawata T;Uno T;et al.
• 通讯作者: et al.

Preoperative radiation therapy for carcinoma of the oropharynx : Prognostic factors for locoregional control and survival.

口咽癌的术前放射治疗：局部控制和生存的预后因素。

• 发表时间: 2003
• 期刊: In vivo 17・2
• 作者: Uno T;Yasuda S;et al.
• 通讯作者: et al.

Efficacy and toxicities of concurrent chemoradiation for elderly patients with esophageal cancer.

老年食管癌同步放化疗的疗效和毒性。

• 发表时间: 2004
• 期刊: Anticancer Res 24・4
• 作者: Uno T;Isobe K;et al.
• 通讯作者: et al.

G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low or high-LET radiation.

暴露于低或高 LET 辐射的正常人成纤维细胞的 G2 染色单体损伤和修复动力学。

• 发表时间: 2004
• 期刊: Cytogenet Genome Res 104(2)
• 作者: Kawata T;Uno T;et al.
• 通讯作者: et al.

Radiation-Induced Chromosome Aberrations in Ataxia Telangiectasia Cell Line : high frequency of deletions and misrejoining detected by fluorescence in situ hybridizarion.

共济失调毛细血管扩张细胞系中辐射诱导的染色体畸变：通过荧光原位杂交检测到高频率的缺失和错误重连。

• 发表时间: 2003
• 期刊: Radiat Res 159・3
• 作者: Kawata T;Uno T;et al.
• 通讯作者: et al.