Basic study of heavy-ion irradiated to the normal brain tissue-Effects of carbon

重离子照射对正常脑组织的基础研究-碳的影响

• 批准号: 21591607
• 负责人: UNO Takashi
• 金额: $ 2.91万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591607/
• 关键词: 放射線治療生物学; 重粒子線; 脳照射; 放射線障害; 母性行動; マウス; 重粒子

Radiation therapy is applied to several brain tumors. This experiment was planned to investigate influence on maternal behavior after the irradiation exposure to brain. The present study was designed to determine whether irradiation (carbon particles 290 MeV/nucleon, Mono Peak 15-45Gy, irradiation field 5mm cube) to cerebrum modifies the maternal behavior of mice. The maternal behavior items were recorded : nest-building (nest weights) and retrieving behavior (Scoring : the time when a mouse takes children back to the nest) of female mice. The 15-30Gy irradiation groups, the maternal behavior was no changed in comparison with non-irradiated (Control) female mice after 3 month following irradiation. However, maternal behavior activity of 45Gy irradiation group decreased. Particularly, the 45Gy irradiation group was suppressed for the retrieving behavior in 3 and 6 months after irradiation.

放射治疗适用于几种脑肿瘤。本实验旨在探讨脑照射对母体行为的影响。本研究旨在确定用290 MeV/核子的碳粒子，Mono Peak 15- 45 Gy，照射野5 mm立方体照射小鼠大脑是否会改变小鼠的母性行为。记录雌性小鼠的母性行为项目：筑巢（巢重）和取回行为（评分：小鼠将孩子带回巢的时间）。15- 30 Gy照射组小鼠在照射后3个月内的母性行为与对照组相比无明显变化。而45 Gy照射组的母体行为活动减少。其中45 Gy照射组在照射后3个月和6个月的恢复行为受到抑制。

项目成果

Radiation Pneumonitis Following Twice-daily Radiotherapy with Concurrent Carboplatin and Paclitaxel in Patients with Stage III Non-small-cell Lung Cancer

• DOI: 10.1093/jjco/hyp190
• 发表时间: 2010-05-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Kobayashi, Hiroki;Uno, Takashi;Ito, Hisao
• 通讯作者: Ito, Hisao

A Consensus-based Guideline Defining the Clinical Target Volume for Pelvic Lymph Nodes in External Beam Radiotherapy for Uterine Cervical Cancer

• DOI: 10.1093/jjco/hyp191
• 发表时间: 2010-05-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Toita, Takafumi;Ohno, Tatsuya;Hiraoka, Masahiro
• 通讯作者: Hiraoka, Masahiro

Fractionated stereotactic radiotherapy as a boost treatment for tumors in the head and neck region

分割立体定向放射治疗作为头颈部肿瘤的加强治疗

• 发表时间: 2010
• 期刊: J. Radiat
• 作者: Uno;T.;Isobe;K.;Ueno;N.;Fukuda;A.;Sudo;S.;Shirotori;H.;Kitahara;I.;Fukushima;T.;Ito;H.
• 通讯作者: H.

Effect of an ATM Kinase Inhibitor on Thermo-and / or Radio-sensitization in Non-proliferating Normal Human Fibroblasts and Osteosarcoma Cells

ATM 激酶抑制剂对非增殖正常人成纤维细胞和骨肉瘤细胞热敏化和/或放射敏化的影响

• 发表时间: 2010
• 作者: Kohei Inoue;T. Kawata;M. Saito;Cuihua Liu;T. Uno;K. Isobe;Hisao Ito
• 通讯作者: Hisao Ito

Postoperative concurrent daily low-dose cisplatin-based chemoradiation improves the prognosis of patients with pathologic T2b or N1 cervical cancer

术后每日同步低剂量顺铂化放疗可改善病理性 T2b 或 N1 宫颈癌患者的预后

• 发表时间: 2010
• 期刊: Anticancer Res
• 影响因子: 2
• 作者: Mitsuhashi A;Uno T;Usui H;Tate S;Hirashiki K;Kato K;Kiyohara H;Kato S;Ito H;Shozu M
• 通讯作者: Shozu M