Basic study of heavy-ion irradiated to the normal brain tissue-Effects of carbon

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Radiation therapy is applied to several brain tumors. This experiment was planned to investigate influence on maternal behavior after the irradiation exposure to brain. The present study was designed to determine whether irradiation (carbon particles 290 MeV/nucleon, Mono Peak 15-45Gy, irradiation field 5mm cube) to cerebrum modifies the maternal behavior of mice. The maternal behavior items were recorded : nest-building (nest weights) and retrieving behavior (Scoring : the time when a mouse takes children back to the nest) of female mice. The 15-30Gy irradiation groups, the maternal behavior was no changed in comparison with non-irradiated (Control) female mice after 3 month following irradiation. However, maternal behavior activity of 45Gy irradiation group decreased. Particularly, the 45Gy irradiation group was suppressed for the retrieving behavior in 3 and 6 months after irradiation.